WormBase Tree Display for Gene: WBGene00000371
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WBGene00000371 | Evidence | Paper_evidence | WBPaper00005707 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | F26E4 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | cox | ||||||
Allele (21) | |||||||
Component_of_genotype | WBGenotype00000141 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation | 00049238 | ||||||
00049239 | |||||||
00049240 | |||||||
00049241 | |||||||
00049242 | |||||||
00049243 | |||||||
00107246 | |||||||
00107247 | |||||||
00107248 | |||||||
Contained_in_operon | CEOP1930 | ||||||
Ortholog (38) | |||||||
Structured_description | Concise_description | cox-5b encodes the ortholog of the nuclear-encoded cytochrome c oxidase-1 subunit Vb/COX4, a component of the electron transport chain in mitochondria; knock-down of cox-5b via RNA interference in specific tissues like body wall muscle decreases life span, whereas knock-down in the nervous system and intestine increases life-span; the effects of cox-5b on life span indicate that the electron transport chain functions in a tissue-specific manner to affect the aging process, and studies show that this effect is dependent on the mitochondrial unfolded protein response. | Paper_evidence | WBPaper00037991 | |||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 04 May 2011 00:00:00 | ||||||
Automated_description | Predicted to enable metal ion binding activity. Involved in determination of adult lifespan; lipid storage; and proton motive force-driven mitochondrial ATP synthesis. Predicted to be located in mitochondrial envelope. Predicted to be part of mitochondrial respiratory chain complex IV. Is an ortholog of human COX5B (cytochrome c oxidase subunit 5B). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Modifies_disease | DOID:450 | ||||||
Modifies_disease_in_annotation | WBDOannot00001305 | ||||||
Molecular_info | Corresponding_CDS | F26E4.9 | |||||
Corresponding_transcript | F26E4.9.1 | ||||||
F26E4.9.2 | |||||||
Other_sequence (85) | |||||||
Associated_feature | WBsf643631 | ||||||
WBsf981084 | |||||||
WBsf984809 | |||||||
WBsf984810 | |||||||
WBsf218348 | |||||||
WBsf218349 | |||||||
WBsf218350 | |||||||
WBsf218351 | |||||||
WBsf218352 | |||||||
Experimental_info | RNAi_result (135) | ||||||
Expr_pattern | Expr1011393 | ||||||
Expr1030199 | |||||||
Expr1149560 | |||||||
Expr2009764 | |||||||
Expr2028004 | |||||||
Drives_construct | WBCnstr00037591 | ||||||
Construct_product | WBCnstr00020784 | ||||||
WBCnstr00020785 | |||||||
WBCnstr00037591 | |||||||
Regulate_expr_cluster (15) | |||||||
Microarray_results (26) | |||||||
Expression_cluster (112) | |||||||
Interaction (119) | |||||||
WBProcess | WBbiopr:00000001 | ||||||
WBbiopr:00000121 | |||||||
Map_info | Map | I | Position | 3.90842 | Error | 0.000958 | |
Positive | Positive_clone | F26E4 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference (41) | |||||||
Remark (2) | |||||||
Method | Gene |