WormBase Tree Display for Gene: WBGene00000211
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WBGene00000211 | Evidence | Paper_evidence | WBPaper00003086 | ||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | B0252 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | asm | ||||||
Allele (27) | |||||||
Strain | WBStrain00001217 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (28) | |||||||
Ortholog (37) | |||||||
Paralog | WBGene00000212 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | |||||||
WBGene00014106 | Caenorhabditis elegans | From_analysis | Panther | ||||
WormBase-Compara | |||||||
WBGene00000213 | Caenorhabditis elegans | From_analysis | TreeFam | ||||
Panther | |||||||
WormBase-Compara | |||||||
Structured_description | Concise_description | asm-1 encodes a protein similar to human acid sphingomyelinase (ASM) or sphingomyelin phosphodiesterase; the ASM-1 protein has a putative secretory signal peptide at the N-terminus, saposin-like and proline-rich domains and putative N-linked glycosylation sites; asm-1 shows phosphodiesterase activity when expressed in COS-7 cells; while mammalian ASM is detected as both intracellular and secreted forms, asm-1 was detected exclusively in the secreted form; northern blot analysis indicates that asm-1 is expressed at higher levels in the embryo compared with other stages. | Paper_evidence | WBPaper00003086 | |||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 07 Aug 2006 00:00:00 | ||||||
Automated_description | Enables sphingomyelin phosphodiesterase activity. Involved in ceramide biosynthetic process and sphingomyelin catabolic process. Located in extracellular region and lysosome. Human ortholog(s) of this gene implicated in Niemann-Pick disease type A and Niemann-Pick disease type B. Is an ortholog of human SMPD1 (sphingomyelin phosphodiesterase 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:14504 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||
DOID:0070112 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||
DOID:0070111 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11120) | ||||
Molecular_info | Corresponding_CDS | B0252.2 | |||||
Corresponding_transcript | B0252.2.1 | ||||||
Other_sequence (13) | |||||||
Associated_feature | WBsf1012454 | ||||||
WBsf221524 | |||||||
Experimental_info | RNAi_result | WBRNAi00038811 | Inferred_automatically | RNAi_primary | |||
Expr_pattern | Chronogram2039 | ||||||
Expr5031 | |||||||
Expr1016463 | |||||||
Expr1030130 | |||||||
Expr1143014 | |||||||
Expr2009454 | |||||||
Expr2027691 | |||||||
Drives_construct | WBCnstr00002110 | ||||||
WBCnstr00007576 | |||||||
WBCnstr00037661 | |||||||
Construct_product | WBCnstr00007576 | ||||||
WBCnstr00037661 | |||||||
Antibody | WBAntibody00001822 | ||||||
Microarray_results (20) | |||||||
Expression_cluster (145) | |||||||
Interaction | WBInteraction000133965 | ||||||
WBInteraction000255751 | |||||||
WBInteraction000428006 | |||||||
Map_info | Map | II | Position | 0.139055 | Error | 0.001453 | |
Positive | Positive_clone | B0252 | Inferred_automatically (2) | ||||
Pseudo_map_position | |||||||
Reference (14) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |