WormBase Tree Display for Gene: WBGene00000068
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WBGene00000068 | Evidence | CGC_data_submission | |||||
---|---|---|---|---|---|---|---|
SMap | S_parent | Sequence | F17C8 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | acy | ||||||
Allele (122) | |||||||
Legacy_information | [Berger AJ, Kaplan JM] nu327 is semidominant suppressor of neurodegeneration induced by constitutive G alpha s. No conspicuous behavioral or other phenotype, odorant response to isoamyl alcohol slightly impaired. OA2: nu329, nu343 similar. Encodes adenylyl cyclase, 40% identical to mammalian adenylyl cyclases. nu327 missense, nu329 and nu343 splice donor mutations. Predicted gene F17C8.1 | ||||||
[Korswagen HC] pk301 (pka sgs-1) suppresses neuronal degeneration induced by activated G alpha s. No obvious defects in development or behavior. Loss-of-function mutation in predicted adenylyl cyclase. OA8: pk310, pk311, pk450::Tc1, etc., all similar. | |||||||
Strain (14) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (22) | |||||||
Ortholog (34) | |||||||
Paralog (36) | |||||||
Structured_description | Concise_description | acy-1 encodes an adenylyl cyclase that is most closely related to the divergent mouse isoform type IX; acy-1 is required for viability, muscle contraction, locomotion, molting, and regulation of sleep-like behavior (lethargus) during larval development; acy-1 acts genetically downstream of gsa-1 and is expressed in excitable cells. | Paper_evidence | WBPaper00003038 | |||
WBPaper00003207 | |||||||
WBPaper00031383 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 06 Nov 2008 00:00:00 | ||||||
Automated_description | Predicted to enable adenylate cyclase activity. Involved in several processes, including locomotory exploration behavior; memory; and regulation of defecation. Predicted to be located in plasma membrane. Expressed in body wall musculature; ganglia; neurons; ventral nerve cord; and vulval muscle. Human ortholog(s) of this gene implicated in mood disorder. Is an ortholog of human ADCY9 (adenylate cyclase 9). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:3324 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:240) | ||
Molecular_info | Corresponding_CDS | F17C8.1 | |||||
Corresponding_transcript | F17C8.1.1 | ||||||
Other_sequence (201) | |||||||
Associated_feature (11) | |||||||
Experimental_info (8) | |||||||
Map_info | Map | III | Position | -2.649 | Error | 0.036999 | |
Well_ordered | |||||||
Positive | Positive_clone | F17C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Mapping_data | Multi_point | 3712 | |||||
4625 | |||||||
Reference (62) | |||||||
Remark | Data extracted from Berger et al. (1998) | ||||||
Data extracted from Korswagen et al. (1998) | |||||||
Sequence connection from [Berger AJ] | |||||||
Positive_clone F17C8 is based on cosmid rescue, mutant sequence [Berger AJ, Kaplan JM, Korswagen HC][[030403 ck1] | |||||||
Method | Gene |