WormBase Tree Display for Gene: WBGene00000051

WBGene00000051 SMap: S_parent: Sequence: R01E6
  Identity: Version: 1
    Name: CGC_name: acr-12 Person_evidence: WBPerson1430
      Sequence_name: R01E6.4
      Molecular_name: R01E6.4a
        R01E6.4a.1
        CE29334
        R01E6.4b
        CE50576
        R01E6.4b.1
      Other_name: CELE_R01E6.4 Accession_evidence: NDB BX284606
      Public_name: acr-12
    DB_info: Database: AceView gene XO153
        WormQTL gene WBGene00000051
        WormFlux gene WBGene00000051
        NDB locus_tag CELE_R01E6.4
        Panther gene CAEEL|EnsemblGenome=WBGene00000051|UniProtKB=G5EDF1
          family PTHR18945
        NCBI gene 181475
        RefSeq protein NM_077861.6
            NM_001313441.4
        TrEMBL UniProtAcc A0A0K3ATC5
            G5EDF1
        UniProt_GCRP UniProtAcc G5EDF1
        OMIM gene 100690
            118503
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:19 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acr
    Allele (84)
    Strain: WBStrain00035572
    RNASeq_FPKM (74)
    GO_annotation (31)
    Ortholog (58)
    Paralog (100)
    Structured_description: Concise_description: acr-12 encodes a nicotinic acetylcholine receptor (nAChR) alpha subunit that is a member of the ACR-8-like group of C. elegans nAChR subunits; as an nAChR subunit, ACR-12 is predicted to mediate fast excitatory neurotransmission, however loss of acr-12 activity via mutation or RNAi results in no obvious defects; ACR-12 copurifies with UNC-29 and LEV-1, suggesting that ACR-12 can form receptors with these two non-alpha AChR subunits; an ACR-12::GFP fusion protein is expressed exclusively in ventral cord motor neurons, including the D neurons; in vivo, ACR-12 colocalizes with some, but not all, UNC-38-containing postsynaptic receptor clusters, suggesting that ACR-12 contributes to only a subset of these receptor clusters. Paper_evidence: WBPaper00003425
            WBPaper00024970
            WBPaper00026635
          Curator_confirmed: WBPerson1843
            WBPerson480
          Date_last_updated: 24 Mar 2006 00:00:00
      Automated_description: Enables acetylcholine-gated monoatomic cation-selective channel activity. Involved in calcium ion import across plasma membrane and regulation of muscle contraction. Located in synapse. Expressed in neurons. Human ortholog(s) of this gene implicated in several diseases, including congenital myasthenic syndrome (multiple); lung disease (multiple); and nicotine dependence. Is an ortholog of human CHRNA1 (cholinergic receptor nicotinic alpha 1 subunit); CHRNA3 (cholinergic receptor nicotinic alpha 3 subunit); and CHRNA6 (cholinergic receptor nicotinic alpha 6 subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3905 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:5409 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:3083 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:10534 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:0110663 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1955)
      DOID:1324 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:3910 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:0050742 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1957)
      DOID:0110662 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:1955)
  Molecular_info: Corresponding_CDS: R01E6.4a
      R01E6.4b
    Corresponding_transcript: R01E6.4a.1
      R01E6.4b.1
    Other_sequence (14)
    Associated_feature: WBsf648676
      WBsf648677
      WBsf663492
      WBsf236578
      WBsf236579
  Experimental_info: RNAi_result: WBRNAi00001836 Inferred_automatically: RNAi_primary
      WBRNAi00017295 Inferred_automatically: RNAi_primary
      WBRNAi00034510 Inferred_automatically: RNAi_primary
      WBRNAi00051097 Inferred_automatically: RNAi_primary
      WBRNAi00102759 Inferred_automatically: RNAi_primary
      WBRNAi00066669 Inferred_automatically: RNAi_primary
      WBRNAi00066392 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr3705
      Expr10601
      Expr10815
      Expr14643
      Expr1022239
      Expr1154804
      Expr2009180
      Expr2027419
    Drives_construct: WBCnstr00006481
      WBCnstr00006482
      WBCnstr00007608
      WBCnstr00008272
      WBCnstr00008273
      WBCnstr00011616
      WBCnstr00017028
      WBCnstr00037767
    Construct_product (15)
    Microarray_results (19)
    Expression_cluster (167)
    Interaction: WBInteraction000313740
      WBInteraction000543444
      WBInteraction000562870
  Map_info: Map: X Position: 12.6983 Error: 0.004605
    Positive: Positive_clone: R01E6 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4138
        4196
    Pseudo_map_position
  Reference (31)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene