WormBase Tree Display for Gene: WBGene00000002
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WBGene00000002 | Evidence | Author_evidence | Veljkovic E | ||||
---|---|---|---|---|---|---|---|
Verrey F | |||||||
SMap | S_parent | Sequence | F27C8 | ||||
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | aat | ||||||
Allele (38) | |||||||
Strain | WBStrain00054846 | ||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (11) | |||||||
Ortholog (62) | |||||||
Paralog (12) | |||||||
Structured_description | Concise_description | aat-1 encodes an amino acid transporter catalytic subunit; when co-expressed in Xenopus oocytes with the ATG-2 glycoprotein subunit, AAT-1 is able to facilitate amino acid uptake and exchange, showing a relatively high affinity for small and some large neutral amino acids; in addition, AAT-1 is able to covalently associate with ATG-2 or ATG-1 to form heterodimers in the Xenopus expression system; when co-expressed with ATG-2, AAT-1 localizes to the cell surface of oocytes, but when expressed alone or with ATG-1, AAT-1 localizes intracellularly. | Paper_evidence | WBPaper00006408 | |||
Curator_confirmed | WBPerson1843 | ||||||
WBPerson567 | |||||||
Date_last_updated | 02 Mar 2006 00:00:00 | ||||||
Automated_description | Contributes to L-amino acid transmembrane transporter activity. Involved in amino acid transmembrane transport. Located in plasma membrane. Part of amino acid transport complex. Expressed in egg-laying apparatus; head motor neurons; and tail. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); glioblastoma; and lysinuric protein intolerance. Is an ortholog of human SLC7A8 (solute carrier family 7 member 8). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (26) | ||||||
Molecular_info | Corresponding_CDS | F27C8.1 | |||||
Corresponding_transcript | F27C8.1.1 | ||||||
Other_sequence (63) | |||||||
Associated_feature (11) | |||||||
Experimental_info (8) | |||||||
Map_info | Map | IV | Position | 4.33112 | Error | 0.001998 | |
Positive | Positive_clone | F27C8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
Pseudo_map_position | |||||||
Reference | WBPaper00006408 | ||||||
WBPaper00024381 | |||||||
WBPaper00035475 | |||||||
WBPaper00038491 | |||||||
WBPaper00042390 | |||||||
WBPaper00045095 | |||||||
WBPaper00050950 | |||||||
WBPaper00053894 | |||||||
WBPaper00055090 | |||||||
WBPaper00060013 | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |