WormBase Tree Display for Gene: RGD:620023
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| RGD:620023 | Identity | Name | CGC_name | Chrm2 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Public_name | Chrm2 | |||||
| DB_info | Database | RGD | id | 620023 | ||
| AGR | cURI | RGD:620023 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSRNOG00000046972 | ||||
| UniProt | UniProt_AC | P10980 | ||||
| Species | Rattus norvegicus | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00001519 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | ||
| Inparanoid | ||||||
| OMA | ||||||
| OrthoFinder | ||||||
| OrthoInspector | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| Structured_description | Automated_description | Enables G protein-coupled acetylcholine receptor activity. Involved in G protein-coupled acetylcholine receptor signaling pathway and regulation of smooth muscle contraction. Located in several cellular components, including asymmetric synapse; neuronal cell body; and symmetric synapse. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Biomarker of depressive disorder. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; bipolar disorder; heroin dependence; major depressive disorder; and schizophrenia. Orthologous to human CHRM2 (cholinergic receptor muscarinic 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; acetylcholine signaling pathway via muscarinic acetylcholine receptors engaging G alphai protein family; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; INTERACTS WITH (+)-pilocarpine; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine. | Inferred_automatically | AGR_import |
