WormBase Tree Display for Gene: RGD:619930
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| RGD:619930 | Identity | Name | CGC_name | Abcb11 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Public_name | Abcb11 | |||||
| DB_info | Database | RGD | id | 619930 | ||
| AGR | cURI | RGD:619930 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSRNOG00000050860 | ||||
| UniProt | UniProt_AC | O70127 | ||||
| Species | Rattus norvegicus | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00003996 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | ||
| Inparanoid | ||||||
| OMA | ||||||
| OrthoInspector | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| WBGene00004002 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | |||
| OrthoFinder | ||||||
| PhylomeDB | ||||||
| WBGene00004000 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | |||
| OrthoFinder | ||||||
| PhylomeDB | ||||||
| WBGene00003997 | Caenorhabditis elegans | From_analysis | OMA | |||
| OrthoFinder | ||||||
| PhylomeDB | ||||||
| WBGene00003998 | Caenorhabditis elegans | From_analysis | OMA | |||
| OrthoFinder | ||||||
| PhylomeDB | ||||||
| WBGene00004001 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | |||
| OrthoFinder | ||||||
| PhylomeDB | ||||||
| Structured_description | Automated_description | Enables ABC-type xenobiotic transporter activity; bile acid transmembrane transporter activity; and carbohydrate transmembrane transporter activity. Involved in several processes, including canalicular bile acid transport; xenobiotic export from cell; and xenobiotic transmembrane transport. Located in Golgi membrane; intracellular canaliculus; and recycling endosome membrane. Used to study cholestasis. Biomarker of alcoholic hepatitis and cholestasis. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11); PARTICIPATES IN bile acid signaling pathway; statin pharmacokinetics pathway; bile acid transport pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; (S)-colchicine; 1,3,5-trinitro-1,3,5-triazinane. | Inferred_automatically | AGR_import |
