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WormBase Tree Display for Gene: HGNC:8652

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Name Class

HGNC:8652IdentityNameCGC_namePcbp4Inferred_automaticallyAGR_import
Other_nameRGD:1317376
CBP
Lip4
LYST-interacting protein
MCG10
RNA binding protein MCG10
alpha-CP4
alphaCP-4 protein
poly(rC)-binding protein 4
Public_namePcbp4
DB_infoDatabaseHGNCid8652
AGRcURIHGNC:8652
EnsEMBLENSEMBL_geneIDENSG00000090097
UniProtUniProt_ACP57723
SpeciesHomo sapiens
StatusLive
Gene_infoBiotypeSO:0001217
OrthologWBGene00003978Caenorhabditis elegansFrom_analysisEnsEMBL-Compara
Inparanoid
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
Structured_descriptionAutomated_descriptionThis gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined. [provided by RefSeq, Jul 2008]Inferred_automaticallyAGR_import