WormBase Tree Display for Gene: HGNC:7007
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| HGNC:7007 | Identity | Name | CGC_name | Rab8a | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name | RGD:1354512 | |||||
| mel | ||||||
| rab8 | ||||||
| mel transforming oncogene (RAB8 homolog) | ||||||
| mel transforming oncogene (derived from cell line NK14) | ||||||
| mel transforming oncogene (derived from cell line NK14)- RAB8 homolog | ||||||
| oncogene c-mel | ||||||
| ras-associated protein RAB8 | ||||||
| ras-related protein Rab-8A | ||||||
| Public_name | Rab8a | |||||
| DB_info | Database | HGNC | id | 7007 | ||
| AGR | cURI | HGNC:7007 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000167461 | ||||
| UniProt | UniProt_AC | P61006 | ||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00004272 | Caenorhabditis elegans | From_analysis | Hieranoid | ||
| Inparanoid | ||||||
| OMA | ||||||
| OrthoFinder | ||||||
| OrthoInspector | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| Structured_description | Automated_description | The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008] | Inferred_automatically | AGR_import |
