WormBase Tree Display for Gene: HGNC:583

HGNC:583 Identity: Name: CGC_name: APC Inferred_automatically: AGR_import
      Other_name (18)
      Public_name: APC
    DB_info: Database: HGNC id 583
        AGR cURI HGNC:583
        EnsEMBL ENSEMBL_geneID ENSG00000134982
        UniProt UniProt_AC P25054
        OMIM gene 611731
        DO id (18)
    Species: Homo sapiens
    Status: Live
  Gene_info: Biotype: SO:0001217
    Ortholog: WBGene00000156 Caenorhabditis elegans From_analysis: EnsEMBL-Compara
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            OrthoInspector
            Panther
    Structured_description: Automated_description: This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Mutations in the APC gene have been found to occur in most colorectal cancers, where disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jun 2022] Inferred_automatically: AGR_import