WormBase Tree Display for Gene: HGNC:5382
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| HGNC:5382 | Identity | Name | CGC_name | Idh1 | Inferred_automatically | AGR_import |
|---|---|---|---|---|---|---|
| Other_name (21) | ||||||
| Public_name | Idh1 | |||||
| DB_info | Database | HGNC | id | 5382 | ||
| AGR | cURI | HGNC:5382 | ||||
| EnsEMBL | ENSEMBL_geneID | ENSG00000138413 | ||||
| UniProt | UniProt_AC | O75874 | ||||
| OMIM | gene | 147700 | ||||
| DO | id | DOID:5016 | ||||
| DOID:4928 | ||||||
| DOID:3068 | ||||||
| DOID:0050908 | ||||||
| DOID:3910 | ||||||
| DOID:3070 | ||||||
| DOID:3907 | ||||||
| DOID:9119 | ||||||
| DOID:417 | ||||||
| Species | Homo sapiens | |||||
| Status | Live | |||||
| Gene_info | Biotype | SO:0001217 | ||||
| Ortholog | WBGene00010317 | Caenorhabditis elegans | From_analysis | EnsEMBL-Compara | ||
| Hieranoid | ||||||
| Inparanoid | ||||||
| OMA | ||||||
| OrthoFinder | ||||||
| OrthoInspector | ||||||
| Panther | ||||||
| PhylomeDB | ||||||
| SonicParanoid | ||||||
| Structured_description | Automated_description | Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013] | Inferred_automatically | AGR_import |
