WormBase Tree Display for Gene: HGNC:4554

HGNC:4554 Identity: Name: CGC_name: Gpx2 Inferred_automatically: AGR_import
      Other_name (14)
      Public_name: Gpx2
    DB_info: Database: HGNC id 4554
        AGR cURI HGNC:4554
        EnsEMBL ENSEMBL_geneID ENSG00000176153
        UniProt UniProt_AC P18283
        DO id DOID:9256
            DOID:0050860
            DOID:8577
            DOID:0080199
    Species: Homo sapiens
    Status: Live
  Gene_info: Biotype: SO:0001217
    Ortholog: WBGene00007516 Caenorhabditis elegans From_analysis: EnsEMBL-Compara
            OMA
            OrthoInspector
            Panther
      WBGene00007517 Caenorhabditis elegans From_analysis: EnsEMBL-Compara
            OMA
            OrthoInspector
            Panther
    Structured_description: Automated_description: The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016] Inferred_automatically: AGR_import