WormBase Tree Display for Gene: WBGene00015418
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| WBGene00015418 | SMap | S_parent | Sequence | CHROMOSOME_III | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 3 | |||||||
| Name | CGC_name | pac-1 | Person_evidence | WBPerson6440 | |||||
| WBPerson440 | |||||||||
| Sequence_name | C04D8.1 | ||||||||
| Molecular_name (18) | |||||||||
| Other_name | CEGAP | Accession_evidence | EMBL | U02289 | |||||
| CELE_C04D8.1 | Accession_evidence | NDB | BX284603 | ||||||
| Public_name | pac-1 | ||||||||
| DB_info | Database | AceView | gene | 3J607 | |||||
| WormQTL | gene | WBGene00015418 | |||||||
| WormFlux | gene | WBGene00015418 | |||||||
| NDB | locus_tag | CELE_C04D8.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00015418|UniProtKB=P34288 | |||||||
| family | PTHR23176 | ||||||||
| NCBI | gene | 176201 | |||||||
| RefSeq | protein | NM_001136361.5 | |||||||
| NM_001306726.3 | |||||||||
| NM_001306727.4 | |||||||||
| NM_001306725.3 | |||||||||
| NM_066476.7 | |||||||||
| NM_001306728.4 | |||||||||
| SwissProt | UniProtAcc | P34288 | |||||||
| TrEMBL | UniProtAcc | U4PM34 | |||||||
| U4PRC7 | |||||||||
| U4PBN0 | |||||||||
| U4PBA1 | |||||||||
| UniProt_GCRP | UniProtAcc | P34288 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:56 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 07 Feb 2008 17:23:14 | WBPerson2970 | Name_change | CGC_name | pac-1 | ||||
| 3 | 03 Nov 2008 13:41:14 | WBPerson1849 | Event | Acquires_merge | WBGene00018372 | ||||
| Acquires_merge | WBGene00018372 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | pac | ||||||||
| Allele (340) | |||||||||
| Strain | WBStrain00032310 | ||||||||
| WBStrain00007530 | |||||||||
| WBStrain00007531 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (18) | |||||||||
| Contained_in_operon | CEOP3814 | ||||||||
| Ortholog (40) | |||||||||
| Paralog | WBGene00008006 | Caenorhabditis elegans | From_analysis | Panther | |||||
| Structured_description | Concise_description | pac-1 encodes a RhoGAP (Rho guanosine triphosphatase (GTPase) activating protein); in the embryo, PAC-1 is essential for establishment of radial (inner-outer) asymmetry and specifically, for differential localization of PAR-6, PAR-3, and PKC-3 to outer somatic cell surfaces devoid of cell-cell contacts; in regulating PAR protein localization, PAC-1 appears to act by spatially regulating activity of the CDC-42 Rho GTPase which can bind PAR-6 and is required, genetically, for PAR-6 localization to the outer cell surface; a PAC-1::GFP fusion protein expressed in the early embryo and in cultured embryos localizes to points of cell-cell contact. | Paper_evidence | WBPaper00031968 | |||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 30 Jun 2008 00:00:00 | ||||||||
| Automated_description | Enables GTPase activator activity. Involved in Rho protein signal transduction; protein localization; and regulation of gastrulation. Located in cell junction. Expressed in anus; epithelial cell; hypodermis; pharynx; and pm7. Is an ortholog of human ARHGAP23 (Rho GTPase activating protein 23). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Molecular_info | Corresponding_CDS | C04D8.1a | |||||||
| C04D8.1b | |||||||||
| C04D8.1d | |||||||||
| C04D8.1e | |||||||||
| C04D8.1f | |||||||||
| C04D8.1g | |||||||||
| Corresponding_CDS_history | C04D8.1:wp92 | ||||||||
| C04D8.1a:wp196 | |||||||||
| C04D8.1c:wp275 | |||||||||
| Corresponding_transcript | C04D8.1a.1 | ||||||||
| C04D8.1b.1 | |||||||||
| C04D8.1d.1 | |||||||||
| C04D8.1e.1 | |||||||||
| C04D8.1f.1 | |||||||||
| C04D8.1g.1 | |||||||||
| Other_sequence (24) | |||||||||
| Associated_feature (62) | |||||||||
| Experimental_info | RNAi_result (7) | ||||||||
| Expr_pattern | Expr68 | ||||||||
| Expr2035 | |||||||||
| Expr8161 | |||||||||
| Expr12368 | |||||||||
| Expr13517 | |||||||||
| Expr1016440 | |||||||||
| Expr1036597 | |||||||||
| Expr1143693 | |||||||||
| Expr2014677 | |||||||||
| Expr2032910 | |||||||||
| Drives_construct | WBCnstr00020487 | ||||||||
| WBCnstr00020494 | |||||||||
| WBCnstr00028863 | |||||||||
| Construct_product (16) | |||||||||
| Microarray_results (39) | |||||||||
| Expression_cluster (124) | |||||||||
| Interaction (75) | |||||||||
| Map_info | Map | III | Position | -0.25513 | Error | 0.000591 | |||
| Positive | Positive_clone | C04D8 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00031968 | ||||||||
| WBPaper00032951 | |||||||||
| WBPaper00032961 | |||||||||
| WBPaper00034623 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00038565 | |||||||||
| WBPaper00038590 | |||||||||
| WBPaper00042051 | |||||||||
| WBPaper00042711 | |||||||||
| WBPaper00046751 | |||||||||
| WBPaper00047316 | |||||||||
| WBPaper00049100 | |||||||||
| WBPaper00053041 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00056801 | |||||||||
| WBPaper00066021 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
