WormBase Tree Display for Gene: WBGene00007984
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| WBGene00007984 | SMap | S_parent | Sequence | CHROMOSOME_I | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | irx-1 | Person_evidence | WBPerson83 | |||||
| WBPerson3132 | |||||||||
| WBPerson1997 | |||||||||
| Sequence_name | C36F7.1 | ||||||||
| Molecular_name | C36F7.1 | ||||||||
| C36F7.1.1 | |||||||||
| CE42075 | |||||||||
| Other_name | CELE_C36F7.1 | Accession_evidence | NDB | BX284601 | |||||
| Public_name | irx-1 | ||||||||
| DB_info | Database | AceView | gene | 1K114 | |||||
| WormQTL | gene | WBGene00007984 | |||||||
| WormFlux | gene | WBGene00007984 | |||||||
| NDB | locus_tag | CELE_C36F7.1 | |||||||
| Panther | gene | CAEEL|WormBase=WBGene00007984|UniProtKB=Q93348 | |||||||
| family | PTHR11211 | ||||||||
| NCBI | gene | 172789 | |||||||
| RefSeq | protein | NM_060132.7 | |||||||
| SwissProt | UniProtAcc | Q93348 | |||||||
| TREEFAM | TREEFAM_ID | TF319371 | |||||||
| UniProt_GCRP | UniProtAcc | Q93348 | |||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 26 May 2004 16:54:48 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of WS125 | ||
| 2 | 18 Jul 2005 13:34:00 | WBPerson2970 | Name_change | CGC_name | irx-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | irx | ||||||||
| Allele (42) | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (14) | |||||||||
| Contained_in_operon | CEOP1895 | ||||||||
| Ortholog (62) | |||||||||
| Structured_description | Concise_description | irx-1 encodes a homeodomain-containing protein that is most similar to members of the Iroquois subclass of TALE (three amino acid loop extension) superclass atypical homeodomain proteins; IRX-1 functions downstream of the UNC-55 nuclear receptor in a transcriptional regulatory network that controls remodeling of the GABAergic DD neuron synapses during larval development. | Paper_evidence | WBPaper00002937 | |||||
| WBPaper00004402 | |||||||||
| WBPaper00024497 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00040363 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 28 Oct 2011 00:00:00 | ||||||||
| Automated_description | Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell development; neuron differentiation; and regulation of transcription by RNA polymerase II. Located in nucleus. Expressed in head muscle; hypodermis; intestine; neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Is an ortholog of several human genes including IRX1 (iroquois homeobox 1); IRX3 (iroquois homeobox 3); and IRX5 (iroquois homeobox 5). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:1682 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14358) | ||||
| DOID:12930 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:14361) | ||||||
| Molecular_info | Corresponding_CDS | C36F7.1 | |||||||
| Corresponding_CDS_history | C36F7.1:wp187 | ||||||||
| Corresponding_transcript | C36F7.1.1 | ||||||||
| Other_sequence (9) | |||||||||
| Associated_feature | WBsf649483 | ||||||||
| WBsf978267 | |||||||||
| WBsf984727 | |||||||||
| WBsf984728 | |||||||||
| WBsf984729 | |||||||||
| WBsf984730 | |||||||||
| WBsf1010391 | |||||||||
| WBsf1010392 | |||||||||
| WBsf1010393 | |||||||||
| Transcription_factor | WBTranscriptionFactor000355 | ||||||||
| Experimental_info | RNAi_result (18) | ||||||||
| Expr_pattern | Expr7467 | ||||||||
| Expr9678 | |||||||||
| Expr10339 | |||||||||
| Expr15623 | |||||||||
| Expr1025765 | |||||||||
| Expr1033472 | |||||||||
| Expr1146080 | |||||||||
| Expr2012868 | |||||||||
| Expr2031102 | |||||||||
| Drives_construct | WBCnstr00009282 | ||||||||
| WBCnstr00012611 | |||||||||
| WBCnstr00015265 | |||||||||
| Construct_product | WBCnstr00009282 | ||||||||
| WBCnstr00009289 | |||||||||
| WBCnstr00009290 | |||||||||
| WBCnstr00016568 | |||||||||
| WBCnstr00021770 | |||||||||
| Microarray_results (25) | |||||||||
| Expression_cluster (193) | |||||||||
| Interaction (34) | |||||||||
| Map_info | Map | I | Position | 3.80092 | Error | 0.000995 | |||
| Positive | Positive_clone | C36F7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Mapping_data | Multi_point | 5375 | |||||||
| 4148 | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00002937 | ||||||||
| WBPaper00027309 | |||||||||
| WBPaper00028710 | |||||||||
| WBPaper00030662 | |||||||||
| WBPaper00030889 | |||||||||
| WBPaper00034721 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040363 | |||||||||
| WBPaper00048350 | |||||||||
| WBPaper00048563 | |||||||||
| WBPaper00052328 | |||||||||
| WBPaper00053207 | |||||||||
| WBPaper00055090 | |||||||||
| WBPaper00060123 | |||||||||
| WBPaper00061738 | |||||||||
| WBPaper00062590 | |||||||||
| WBPaper00064339 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
