WormBase Tree Display for Gene: WBGene00004303
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WBGene00004303 | SMap | S_parent | Sequence | C29E4 | |||
---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||
Name | CGC_name | ran-2 | |||||
Sequence_name | C29E4.3 | ||||||
Molecular_name | C29E4.3a | ||||||
C29E4.3a.1 | |||||||
CE37483 | |||||||
C29E4.3b | |||||||
CE30621 | |||||||
C29E4.3b.1 | |||||||
C29E4.3b.2 | |||||||
Other_name | pna-3 | Person_evidence | WBPerson561 | ||||
CELE_C29E4.3 | Accession_evidence | NDB | BX284603 | ||||
Public_name | ran-2 | ||||||
DB_info | Database | AceView | gene | 3J25 | |||
WormQTL | gene | WBGene00004303 | |||||
WormFlux | gene | WBGene00004303 | |||||
NDB | locus_tag | CELE_C29E4.3 | |||||
Panther | gene | CAEEL|WormBase=WBGene00004303|UniProtKB=P34342 | |||||
family | PTHR24113 | ||||||
NCBI | gene | 176115 | |||||
RefSeq | protein | NM_171884.5 | |||||
NM_171198.8 | |||||||
SwissProt | UniProtAcc | P34342 | |||||
TREEFAM | TREEFAM_ID | TF318283 | |||||
UniProt_GCRP | UniProtAcc | P34342 | |||||
Species | Caenorhabditis elegans | ||||||
History | Version_change (2) | ||||||
Acquires_merge | WBGene00004067 | ||||||
Status | Live | ||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | ran | ||||||
Allele (51) | |||||||
Legacy_information | [Schnabel H] maternal effect embryonic lethal with abnormal pronuclear apppearance | ||||||
Strain | WBStrain00036599 | ||||||
WBStrain00007779 | |||||||
WBStrain00054780 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (13) | |||||||
Contained_in_operon | CEOP3465 | ||||||
Ortholog (47) | |||||||
Structured_description | Concise_description | ran-2 encodes the C. elegans RanGAP (GTPase activating protein) homolog, conserved amongst yeast, Drosophila (segregation distorter), Xenopus, and humans; by homology, RAN-2 is predicted to function as a key regulator of the Ran GTP/GDP cycle by stimulating the otherwise weak Ran GTPase activity; in C. elegans, RAN-2 activity is essential during early embryogenesis for comigration of centrosomes with the male pronucleus, mitotic spindle formation, chromosome segregation, and nuclear envelope assembly; in addition, RAN-2 is also required for nucleocytoplasmic transport; ran-2 reporter gene expression is detected in embryos and larvae. | Paper_evidence | WBPaper00004403 | |||
WBPaper00004651 | |||||||
WBPaper00005178 | |||||||
WBPaper00005637 | |||||||
WBPaper00011686 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable GTPase activator activity and small GTPase binding activity. Involved in embryo development. Predicted to be located in cytosol; nucleus; and perinuclear region of cytoplasm. Expressed in intestinal cell. Is an ortholog of human RANGAP1 (Ran GTPase activating protein 1). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | C29E4.3a | |||||
C29E4.3b | |||||||
Corresponding_CDS_history | C29E4.3a:wp130 | ||||||
Corresponding_transcript | C29E4.3a.1 | ||||||
C29E4.3b.1 | |||||||
C29E4.3b.2 | |||||||
Other_sequence (24) | |||||||
Associated_feature | WBsf645370 | ||||||
WBsf645371 | |||||||
WBsf976236 | |||||||
WBsf976237 | |||||||
WBsf225302 | |||||||
WBsf225303 | |||||||
WBsf225304 | |||||||
WBsf225305 | |||||||
Experimental_info (5) | |||||||
Map_info | Map | III | Position | -0.48356 | Error | 0.002198 | |
Positive | Positive_clone | C29E4 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Pseudo_map_position | |||||||
Reference | WBPaper00003469 | ||||||
WBPaper00005178 | |||||||
WBPaper00005637 | |||||||
WBPaper00011459 | |||||||
WBPaper00028012 | |||||||
WBPaper00028457 | |||||||
WBPaper00028478 | |||||||
WBPaper00038491 | |||||||
WBPaper00046607 | |||||||
WBPaper00055090 | |||||||
WBPaper00065742 | |||||||
Remark | Sequence connection from [Askjaer P, Mattaj IW]. krb 13/11/01 | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |