WormBase Tree Display for Gene: WBGene00004063
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WBGene00004063 | SMap | S_parent | Sequence | CHROMOSOME_I | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pmr | ||||||
Allele (285) | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (35) | |||||||
Contained_in_operon | CEOP1682 | ||||||
Ortholog (42) | |||||||
Paralog (14) | |||||||
Structured_description | Concise_description | The pmr-1 gene encodes a Golgi P-type ATPase Ca^2+/Mn^2+-pump; mutations in its human ortholog, ATP2C1, cause Hailey-Hailey disease (OMIM:169600). | Paper_evidence | WBPaper00004659 | |||
Curator_confirmed | WBPerson1823 | ||||||
WBPerson567 | |||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Enables P-type calcium transporter activity and P-type manganese transporter activity. Involved in several processes, including metal ion transport; response to metal ion; and response to oxidative stress. Located in Golgi apparatus and membrane. Expressed in male gonad; seam cell; and spermatheca. Human ortholog(s) of this gene implicated in Hailey-Hailey disease. Is an ortholog of human ATP2C1 (ATPase secretory pathway Ca2+ transporting 1) and ATP2C2 (ATPase secretory pathway Ca2+ transporting 2). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model | DOID:0050429 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:13211) | ||
Disease_relevance | C. elegans is an effective model system to study heat-related pathologies like heat stroke; in elegans, a small heat shock protein (sHSP), HSP-16.1 has a protective effect against heat-induced necrosis; HSP-16.1 localizes to the golgi and functions together with the PMR-1/PMR1 Ca2+ and Mn2+ transporting ATPase, and NUCB-1/Nucleobindin1, a golgi-located calcium-buffering protein, to maintain calcium homeostasis, under heat stroke; overexpression of pmr-1/PMR1 is sufficient to promote survival after heat stroke, bypassing both HSF-1 and HSP-16.1, indicating that PMR-1/PMR1 functions downstream of both these genes. | Homo sapiens | Paper_evidence | WBPaper00041564 | |||
Curator_confirmed | WBPerson324 | ||||||
Date_last_updated | 29 May 2013 00:00:00 | ||||||
Molecular_info | Corresponding_CDS | ZK256.1a | |||||
ZK256.1b | |||||||
ZK256.1c | |||||||
Corresponding_CDS_history | ZK256.1:wp114 | ||||||
ZK256.1a:wp49 | |||||||
ZK256.1b:wp77 | |||||||
Corresponding_transcript | ZK256.1a.1 | ||||||
ZK256.1a.2 | |||||||
ZK256.1a.3 | |||||||
ZK256.1b.1 | |||||||
ZK256.1c.1 | |||||||
Other_sequence (75) | |||||||
Associated_feature (13) | |||||||
Experimental_info | RNAi_result | WBRNAi00059919 | Inferred_automatically | RNAi_primary | |||
WBRNAi00038238 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00116858 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059917 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059303 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059920 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00086175 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00059921 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Chronogram1105 | ||||||
Expr3187 | |||||||
Expr7200 | |||||||
Expr1017781 | |||||||
Expr1031961 | |||||||
Expr1162731 | |||||||
Expr2014977 | |||||||
Expr2033212 | |||||||
Drives_construct | WBCnstr00003233 | ||||||
WBCnstr00011207 | |||||||
Construct_product | WBCnstr00011207 | ||||||
Antibody | WBAntibody00000363 | ||||||
Microarray_results (31) | |||||||
Expression_cluster (114) | |||||||
Interaction (69) | |||||||
Map_info | Map | I | Position | 17.0977 | Error | 0.064933 | |
Positive | Positive_clone | ZK256 | Inferred_automatically | From CDS info | |||
From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 5071 | |||||
Pseudo_map_position | |||||||
Reference | WBPaper00004659 | ||||||
WBPaper00004921 | |||||||
WBPaper00010207 | |||||||
WBPaper00012944 | |||||||
WBPaper00024915 | |||||||
WBPaper00033965 | |||||||
WBPaper00035236 | |||||||
WBPaper00038491 | |||||||
WBPaper00038657 | |||||||
WBPaper00039106 | |||||||
WBPaper00039504 | |||||||
WBPaper00041564 | |||||||
WBPaper00042427 | |||||||
WBPaper00042761 | |||||||
WBPaper00044405 | |||||||
WBPaper00048828 | |||||||
WBPaper00055090 | |||||||
WBPaper00057753 | |||||||
WBPaper00059901 | |||||||
WBPaper00060842 | |||||||
WBPaper00063079 | |||||||
WBPaper00064339 | |||||||
Remark | Sequence connection from [Van Baelenk, Wuytack, F] | ||||||
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | ||||||
Method | Gene |