WormBase Tree Display for Gene: WBGene00003369
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WBGene00003369 | SMap | S_parent | Sequence | C36E6 | ||
---|---|---|---|---|---|---|
Identity (6) | ||||||
Gene_info | Biotype | SO:0001217 | ||||
Gene_class | mlc | |||||
Allele (20) | ||||||
Legacy_information | [C.elegansII] Deletions (eg sup-10(n184)) viable, normal muscle; increased lethality of mlc-2(0).Resembles mammalian non-muscle MLC; expressed in both pharynx and body wall. Not transpliced. [Cummins and Anderson 1988; TR] | |||||
RNASeq_FPKM (74) | ||||||
GO_annotation (14) | ||||||
Ortholog (72) | ||||||
Paralog | WBGene00003370 | Caenorhabditis elegans | From_analysis | Inparanoid_8 | ||
Panther | ||||||
WormBase-Compara | ||||||
WBGene00003372 | Caenorhabditis elegans | From_analysis | Panther | |||
WormBase-Compara | ||||||
Structured_description | Concise_description | mlc-1 encodes a muscle regulatory myosin light chain that is nearly identical to MLC-2 and functions redundantly with MLC-2 in the body-wall and in pharyngeal muscle to affect L1 larval viability, elongation, and pharyngeal and body-wall muscle development, and also affects locomotion and growth; expressed in the body-wall muscles, pharyngeal muscles, and vulval muscles. | Paper_evidence | WBPaper00001094 | ||
WBPaper00003259 | ||||||
WBPaper00006395 | ||||||
Curator_confirmed | WBPerson48 | |||||
Date_last_updated | 09 Aug 2004 00:00:00 | |||||
Automated_description | Predicted to enable myosin heavy chain binding activity. Involved in several processes, including muscle organ development; nematode larval development; and regulation of muscle contraction. Part of muscle myosin complex. Expressed in anal depressor muscle; body wall musculature; pharyngeal muscle cell; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in distal arthrogryposis type 1C and hypertrophic cardiomyopathy 10. Is an ortholog of human MYL10 (myosin light chain 10); MYL5 (myosin light chain 5); and MYL7 (myosin light chain 7). | Paper_evidence | WBPaper00065943 | |||
Curator_confirmed | WBPerson324 | |||||
WBPerson37462 | ||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | |||||
Date_last_updated | 29 Nov 2023 00:00:00 | |||||
Disease_info | Potential_model | DOID:0112190 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:29824) | |
DOID:0110316 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7583) | |||
DOID:0080326 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:7583) | |||
Molecular_info | Corresponding_CDS | C36E6.3 | ||||
Corresponding_CDS_history | C36E6.3:wp102 | |||||
Corresponding_transcript | C36E6.3.1 | |||||
Other_sequence (127) | ||||||
Associated_feature (11) | ||||||
Experimental_info | RNAi_result | WBRNAi00042074 | Inferred_automatically | RNAi_primary | ||
WBRNAi00024757 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00027213 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00011705 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00011703 | Inferred_automatically | RNAi_primary | ||||
WBRNAi00059498 | Inferred_automatically | RNAi_primary | ||||
Expr_pattern | Expr2736 | |||||
Expr4931 | ||||||
Expr1023343 | ||||||
Expr1031548 | ||||||
Expr1146071 | ||||||
Expr2013589 | ||||||
Expr2031822 | ||||||
Drives_construct (12) | ||||||
Construct_product | WBCnstr00036156 | |||||
Microarray_results (19) | ||||||
Expression_cluster (253) | ||||||
Interaction (32) | ||||||
Map_info | Map | X | Position | 24.14 | ||
Well_ordered | ||||||
Positive | Positive_clone | C36E6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||
ZK54 | ||||||
Mapping_data | Multi_point | 4734 | ||||
Pos_neg_data | 5855 | |||||
5856 | ||||||
5857 | ||||||
5858 | ||||||
5859 | ||||||
5860 | ||||||
5861 | ||||||
Reference | WBPaper00001092 | |||||
WBPaper00001094 | ||||||
WBPaper00001230 | ||||||
WBPaper00001672 | ||||||
WBPaper00001754 | ||||||
WBPaper00001772 | ||||||
WBPaper00001807 | ||||||
WBPaper00001813 | ||||||
WBPaper00002006 | ||||||
WBPaper00003259 | ||||||
WBPaper00003624 | ||||||
WBPaper00006047 | ||||||
WBPaper00006395 | ||||||
WBPaper00013746 | ||||||
WBPaper00013770 | ||||||
WBPaper00013846 | ||||||
WBPaper00013929 | ||||||
WBPaper00013985 | ||||||
WBPaper00014149 | ||||||
WBPaper00014375 | ||||||
WBPaper00014561 | ||||||
WBPaper00016374 | ||||||
WBPaper00020890 | ||||||
WBPaper00020980 | ||||||
WBPaper00021105 | ||||||
WBPaper00022127 | ||||||
WBPaper00027253 | ||||||
WBPaper00028360 | ||||||
WBPaper00029438 | ||||||
WBPaper00031003 | ||||||
WBPaper00037615 | ||||||
WBPaper00038491 | ||||||
WBPaper00041022 | ||||||
WBPaper00041771 | ||||||
WBPaper00049828 | ||||||
WBPaper00055090 | ||||||
WBPaper00056474 | ||||||
WBPaper00060171 | ||||||
WBPaper00060779 | ||||||
WBPaper00063976 | ||||||
WBPaper00064354 | ||||||
Remark | 2 sequences can't be resolved yet, big duplication in cosmid which is not fully analysed. see also mlc-2. sdm 12/00 | |||||
However, blastn of genomic EMBL sequence to genomic clones : mlc-1 matches 100% to C36E6.f apart from 5' exon. So removing .b sequence from here. sdm 12/00 | ||||||
C36E6.f changed to .3 [sdm 0103] | ||||||
Method | Gene |