WormBase Tree Display for Gene: WBGene00003225

WBGene00003225 SMap: S_parent: Sequence: T07C4
  Identity: Version: 2
    Name: CGC_name: mev-1 Person_evidence: WBPerson286
      Sequence_name: T07C4.7
      Molecular_name: T07C4.7a
        T07C4.7a.1
        CE00598
        T07C4.7b
        CE50785
        T07C4.7b.1
      Other_name: cyt-1
        sdhc-1 Person_evidence: WBPerson205
        CELE_T07C4.7 Accession_evidence: NDB BX284603
      Public_name: mev-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
        2 19 Jul 2006 13:37:01 WBPerson2970 Name_change: Other_name: sdhc-1
    Status: Live
  Gene_info (12)
  Disease_info: Potential_model: DOID:3908 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10682)
      DOID:0080533 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10682)
      DOID:0050773 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10682)
      DOID:9253 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10682)
    Disease_relevance: C. elegans is used as a model system to study the molecular mechanisms underlying diabetic hyperglycemia-induced reduction in life-span; studies in the mev-1 mutant strain of C. elegans, which carries a mutation in the cytochrome b subunit of succinate dehydrogenase and displays increased mitochondrial reactive oxygen species (ROS) generation, in analogy to the situation observed in insulin-resistance, indicate that an impaired proteosomal degradation system and accumulation of misfolded/unfolded proteins underlies glucose induced life-span reduction. Homo sapiens Paper_evidence: WBPaper00041961
          Curator_confirmed: WBPerson324
          Date_last_updated: 11 Mar 2013 00:00:00
  Molecular_info: Corresponding_CDS: T07C4.7a
      T07C4.7b
    Corresponding_transcript: T07C4.7a.1
      T07C4.7b.1
    Other_sequence (104)
    Associated_feature: WBsf645557
      WBsf659493
      WBsf659494
      WBsf225708
  Experimental_info: RNAi_result (28)
    Expr_pattern: Expr4391
      Expr1027219
      Expr1031524
      Expr1156340
      Expr2013540
      Expr2031774
    Drives_construct (3)
    Construct_product: WBCnstr00000780
      WBCnstr00036176
      WBCnstr00042214
    Regulate_expr_cluster: WBPaper00046217:mev-1(kn1)_downregulated
      WBPaper00046217:mev-1(kn1)_upregulated
    Antibody: WBAntibody00000642
    Microarray_results (21)
    Expression_cluster (121)
    Interaction (95)
    WBProcess: WBbiopr:00000001
      WBbiopr:00000014
      WBbiopr:00000065
  Map_info: Map: III Position: 2.348
    Well_ordered
    Positive: Positive_clone: T07C4 Inferred_automatically: From sequence, transcript, pseudogene data
    Negative: Negative_clone: C38H2
    Mapping_data: Multi_point: 1752
        1753
        1754
        1755
        1756
        1757
        1824
        2407
        3547
  Reference: WBPaper00001342
    WBPaper00001426
    WBPaper00001532
    WBPaper00001699
    WBPaper00001739
    WBPaper00001776
    WBPaper00001921
    WBPaper00001983
    WBPaper00002006
    WBPaper00002153
    WBPaper00002196
    WBPaper00002329
    WBPaper00002402
    WBPaper00002598
    WBPaper00002936
    WBPaper00003035
    WBPaper00003146
    WBPaper00003157
    WBPaper00003293
    WBPaper00003315
    WBPaper00003366
    WBPaper00003872
    WBPaper00003925
    WBPaper00004220
    WBPaper00004288
    WBPaper00004294
    WBPaper00004425
    WBPaper00004516
    WBPaper00004541
    WBPaper00004570
    WBPaper00004744
    WBPaper00004898
    WBPaper00004913
    WBPaper00004973
    WBPaper00004984
    WBPaper00005206
    WBPaper00005207
    WBPaper00005333
    WBPaper00005389
    WBPaper00005516
    WBPaper00005526
    WBPaper00005647
    WBPaper00005674
    WBPaper00005802
    WBPaper00005920
    WBPaper00006217
    WBPaper00006374
    WBPaper00010662
    WBPaper00011893
    WBPaper00011894
    WBPaper00011953
    WBPaper00011955
    WBPaper00012580
    WBPaper00013060
    WBPaper00014008
    WBPaper00014609
    WBPaper00015121
    WBPaper00015597
    WBPaper00015703
    WBPaper00015786
    WBPaper00017920
    WBPaper00017924
    WBPaper00018237
    WBPaper00018474
    WBPaper00018475
    WBPaper00018476
    WBPaper00019107
    WBPaper00019109
    WBPaper00019125
    WBPaper00019128
    WBPaper00020827
    WBPaper00021883
    WBPaper00022393
    WBPaper00022430
    WBPaper00022833
    WBPaper00023207
    WBPaper00023265
    WBPaper00023626
    WBPaper00023810
    WBPaper00023813
    WBPaper00024203
    WBPaper00024204
    WBPaper00024393
    WBPaper00024513
    WBPaper00024718
    WBPaper00024968
    WBPaper00025004
    WBPaper00025130
    WBPaper00025181
    WBPaper00025191
    WBPaper00025224
    WBPaper00025634
    WBPaper00025903
    WBPaper00025969
    WBPaper00026247
    WBPaper00026415
    WBPaper00026674
    WBPaper00026725
    WBPaper00027061
    WBPaper00027145
    WBPaper00027167
    WBPaper00027264
    WBPaper00027283
    WBPaper00028253
    WBPaper00028282
    WBPaper00028365
    WBPaper00028429
    WBPaper00028561
    WBPaper00028790
    WBPaper00029088
    WBPaper00029203
    WBPaper00029409
    WBPaper00030955
    WBPaper00031065
    WBPaper00031296
    WBPaper00031319
    WBPaper00031379
    WBPaper00031533
    WBPaper00031648
    WBPaper00031672
    WBPaper00031688
    WBPaper00031918
    WBPaper00031941
    WBPaper00032136
    WBPaper00032390
    WBPaper00032435
    WBPaper00032605
    WBPaper00032923
    WBPaper00033133
    WBPaper00033158
    WBPaper00033285
    WBPaper00033448
    WBPaper00034694
    WBPaper00034705
    WBPaper00035615
    WBPaper00036124
    WBPaper00036440
    WBPaper00037043
    WBPaper00037044
    WBPaper00037608
    WBPaper00037918
    WBPaper00038082
    WBPaper00038471
    WBPaper00038491
    WBPaper00039989
    WBPaper00040005
    WBPaper00040088
    WBPaper00040109
    WBPaper00040122
    WBPaper00040161
    WBPaper00040222
    WBPaper00040490
    WBPaper00040519
    WBPaper00040524
    WBPaper00040525
    WBPaper00040582
    WBPaper00041728
    WBPaper00041750
    WBPaper00041882
    WBPaper00041961
    WBPaper00042382
    WBPaper00042459
    WBPaper00043004
    WBPaper00044324
    WBPaper00044685
    WBPaper00044730
    WBPaper00044789
    WBPaper00044866
    WBPaper00044938
    WBPaper00045008
    WBPaper00045075
    WBPaper00045076
    WBPaper00045266
    WBPaper00045295
    WBPaper00045933
    WBPaper00046168
    WBPaper00046210
    WBPaper00046368
    WBPaper00046533
    WBPaper00046568
    WBPaper00046575
    WBPaper00046605
    WBPaper00046620
    WBPaper00046760
    WBPaper00046996
    WBPaper00047026
    WBPaper00047117
    WBPaper00047671
    WBPaper00047672
    WBPaper00047722
    WBPaper00048601
    WBPaper00048625
    WBPaper00049416
    WBPaper00049557
    WBPaper00049659
    WBPaper00049780
    WBPaper00049828
    WBPaper00049865
    WBPaper00050435
    WBPaper00050574
    WBPaper00050648
    WBPaper00050737
    WBPaper00051554
    WBPaper00051659
    WBPaper00051771
    WBPaper00053125
    WBPaper00053409
    WBPaper00054527
    WBPaper00054769
    WBPaper00054865
    WBPaper00054892
    WBPaper00054936
    WBPaper00054980
    WBPaper00055007
    WBPaper00055090
    WBPaper00055281
    WBPaper00055326
    WBPaper00056299
    WBPaper00056454
    WBPaper00057362
    WBPaper00058572
    WBPaper00058699
    WBPaper00058851
    WBPaper00059321
    WBPaper00059393
    WBPaper00059520
    WBPaper00059644
    WBPaper00059741
    WBPaper00059947
    WBPaper00060184
    WBPaper00060535
    WBPaper00060692
    WBPaper00061067
    WBPaper00061328
    WBPaper00061745
    WBPaper00061807
    WBPaper00061852
    WBPaper00062577
    WBPaper00062625
    WBPaper00062827
    WBPaper00062978
    WBPaper00064028
    WBPaper00064251
    WBPaper00064272
    WBPaper00064457
    WBPaper00065165
    WBPaper00065614
    WBPaper00066039
  Remark: Rescue data communicated by Hartman PS
    extracted from Ishii et al. (1998)
    Positive_clone is based on transformation rescue, mutant sequence [Ishii N, Hartman PS][030403 ck1]
    Negative_clone is based on no rescue [Ishii N, Hartman PS][030403 ck1]
    [200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (2.32414)
  Method: Gene