WormBase Tree Display for Gene: WBGene00003020

WBGene00003020 SMap: S_parent: Sequence: C32F10
  Identity: Version: 1
    Name: CGC_name: lin-35 Person_evidence: WBPerson261
      Sequence_name: C32F10.2
      Molecular_name: C32F10.2
        C32F10.2.1
        CE24823
      Other_name: CELE_C32F10.2 Accession_evidence: NDB BX284601
      Public_name: lin-35
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:30 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: lin
    Allele (104)
    Legacy_information: n745 : wildtype alone Muv in homozygotes with lin-8 lin-38 or lin-15(n767). ES2. NA2 (n373 (similar phenotype)).
      See also n373, n745
      [C.elegansII] n745 : almost WT alone (reduced fertility); Muv (extra vulval differentiation) in homozygotes with lin-8, lin-38 or lin-15(n767). ES2. OA1: n373 (similar). [Ferguson and Horvitz 1989; MT; PS]
    Strain (17)
    Component_of_genotype: WBGenotype00000009
    RNASeq_FPKM (74)
    GO_annotation (50)
    Ortholog (43)
    Structured_description: Concise_description: lin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, loss of lin-35 activity results in enhanced RNA interference; lin-35 activity is also required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells. Paper_evidence: WBPaper00003329
            WBPaper00004635
            WBPaper00005137
            WBPaper00005931
            WBPaper00024215
            WBPaper00024320
            WBPaper00024322
            WBPaper00024692
            WBPaper00027135
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 05 May 2009 00:00:00
      Automated_description: Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cell cycle; negative regulation of vulval development; and positive regulation of brood size. Located in nucleus. Expressed in several structures, including head and tail. Used to study intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including germ cell cancer (multiple); high grade glioma (multiple); and urinary system cancer (multiple). Is an ortholog of human RBL1 (RB transcriptional corepressor like 1) and RBL2 (RB transcriptional corepressor like 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1059 Homo sapiens Paper_evidence: WBPaper00024322
          Accession_evidence: OMIM 309580
          Curator_confirmed: WBPerson324
          Date_last_updated: 18 Apr 2013 00:00:00
    Potential_model (16)
    Disease_relevance: Human ATRX encodes a protein with a ATPase/helicase domain involved in chromatin remodeling, mutations in which, have been associated with alpha-thalassemia and X-linked mental retardation; the elegans ortholog, xnp-1 is required for gonadal development and acts in association with lin-35/Retinoblastoma (RB), components of the NuRD complex and hpl-2/HP1 genes; the requirement of xnp-1 with lin-35/ Rb in larval development in C. elegans can be compared with the observation that in humans, XNP/ATR-X mutation is also associated, with short stature and skeletal abnormalities during development. Homo sapiens Paper_evidence: WBPaper00024322
            WBPaper00024692
            WBPaper00003646
          Curator_confirmed: WBPerson324
          Date_last_updated: 23 Apr 2013 00:00:00
  Models_disease_asserted: WBDOannot00000614
    WBDOannot00001021
  Molecular_info: Corresponding_CDS: C32F10.2
    Corresponding_transcript: C32F10.2.1
    Associated_feature: WBsf643315
      WBsf643316
      WBsf656335
      WBsf656336
      WBsf656337
      WBsf656338
      WBsf983774
      WBsf217712
    Gene_product_binds (376)
    Transcription_factor: WBTranscriptionFactor000270
  Experimental_info: RNAi_result (78)
    Expr_pattern: Chronogram622
      Expr1291
      Expr3128
      Expr1015789
      Expr1031411
      Expr1145718
      Expr2013177
      Expr2031409
    Drives_construct: WBCnstr00004066
      WBCnstr00006281
      WBCnstr00011156
      WBCnstr00017294
      WBCnstr00036281
    Construct_product: WBCnstr00006281
      WBCnstr00011156
      WBCnstr00017287
      WBCnstr00017294
      WBCnstr00017295
      WBCnstr00017296
      WBCnstr00021077
      WBCnstr00021078
      WBCnstr00021079
      WBCnstr00036281
    Regulate_expr_cluster (16)
    Antibody: WBAntibody00000200
      WBAntibody00001176
      WBAntibody00003008
      WBAntibody00003009
    Microarray_results (20)
    Expression_cluster (156)
    Interaction (322)
    Product_binds_matrix: WBPmat00005534
      WBPmat00005535
      WBPmat00005536
      WBPmat00005540
      WBPmat00005541
      WBPmat00005542
      WBPmat00005543
      WBPmat00005544
      WBPmat00005545
  Map_info (4)
  Reference: WBPaper00001182
    WBPaper00001736
    WBPaper00001794
    WBPaper00002219
    WBPaper00003329
    WBPaper00003632
    WBPaper00003822
    WBPaper00003827
    WBPaper00003861
    WBPaper00004202
    WBPaper00004224
    WBPaper00004489
    WBPaper00004635
    WBPaper00004996
    WBPaper00005046
    WBPaper00005137
    WBPaper00005165
    WBPaper00005176
    WBPaper00005298
    WBPaper00005792
    WBPaper00005861
    WBPaper00005931
    WBPaper00006022
    WBPaper00006435
    WBPaper00010179
    WBPaper00010190
    WBPaper00010274
    WBPaper00010365
    WBPaper00010377
    WBPaper00010569
    WBPaper00010587
    WBPaper00010651
    WBPaper00010660
    WBPaper00010688
    WBPaper00010725
    WBPaper00010737
    WBPaper00010744
    WBPaper00010760
    WBPaper00010855
    WBPaper00010878
    WBPaper00011074
    WBPaper00011207
    WBPaper00011617
    WBPaper00011855
    WBPaper00013412
    WBPaper00016635
    WBPaper00016866
    WBPaper00017596
    WBPaper00017597
    WBPaper00017747
    WBPaper00017802
    WBPaper00017803
    WBPaper00018381
    WBPaper00018426
    WBPaper00018644
    WBPaper00018713
    WBPaper00018730
    WBPaper00018736
    WBPaper00018851
    WBPaper00018965
    WBPaper00019045
    WBPaper00019479
    WBPaper00019602
    WBPaper00019686
    WBPaper00019697
    WBPaper00019698
    WBPaper00019708
    WBPaper00019755
    WBPaper00019787
    WBPaper00019790
    WBPaper00021002
    WBPaper00022510
    WBPaper00022902
    WBPaper00024012
    WBPaper00024013
    WBPaper00024017
    WBPaper00024020
    WBPaper00024126
    WBPaper00024215
    WBPaper00024252
    WBPaper00024303
    WBPaper00024311
    WBPaper00024320
    WBPaper00024322
    WBPaper00024355
    WBPaper00024675
    WBPaper00024692
    WBPaper00024734
    WBPaper00025091
    WBPaper00025318
    WBPaper00025358
    WBPaper00025640
    WBPaper00025700
    WBPaper00025706
    WBPaper00025731
    WBPaper00025803
    WBPaper00025949
    WBPaper00026008
    WBPaper00026062
    WBPaper00026133
    WBPaper00026338
    WBPaper00026347
    WBPaper00026636
    WBPaper00026665
    WBPaper00026675
    WBPaper00026688
    WBPaper00026839
    WBPaper00026891
    WBPaper00026963
    WBPaper00027075
    WBPaper00027135
    WBPaper00027225
    WBPaper00027234
    WBPaper00027236
    WBPaper00027253
    WBPaper00027309
    WBPaper00027315
    WBPaper00027316
    WBPaper00027318
    WBPaper00027336
    WBPaper00027425
    WBPaper00027533
    WBPaper00027620
    WBPaper00027633
    WBPaper00027634
    WBPaper00027681
    WBPaper00027723
    WBPaper00027758
    WBPaper00027805
    WBPaper00027810
    WBPaper00027828
    WBPaper00027860
    WBPaper00027868
    WBPaper00027885
    WBPaper00027963
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    WBPaper00028280
    WBPaper00028381
    WBPaper00028406
    WBPaper00028554
    WBPaper00028752
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    WBPaper00029005
    WBPaper00029033
    WBPaper00029038
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    WBPaper00029251
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    WBPaper00029433
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    WBPaper00030666
    WBPaper00030715
    WBPaper00030864
    WBPaper00030954
    WBPaper00030994
    WBPaper00031045
    WBPaper00031331
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    WBPaper00031832
    WBPaper00031936
    WBPaper00033164
    WBPaper00033265
    WBPaper00033464
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    WBPaper00034347
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    WBPaper00034391
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    WBPaper00034803
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    WBPaper00035912
    WBPaper00036337
    WBPaper00036835
    WBPaper00036970
    WBPaper00036998
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    WBPaper00038168
    WBPaper00038372
    WBPaper00038491
    WBPaper00038632
    WBPaper00039178
    WBPaper00039682
    WBPaper00039717
    WBPaper00039719
    WBPaper00039805
    WBPaper00040876
    WBPaper00041001
    WBPaper00041967
    WBPaper00042673
    WBPaper00042703
    WBPaper00042805
    WBPaper00042812
    WBPaper00042822
    WBPaper00042823
    WBPaper00042966
    WBPaper00043659
    WBPaper00043680
    WBPaper00043760
    WBPaper00043989
    WBPaper00044144
    WBPaper00044235
    WBPaper00044242
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    WBPaper00044798
    WBPaper00044900
    WBPaper00045096
    WBPaper00045160
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    WBPaper00046509
    WBPaper00046889
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    WBPaper00050199
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    WBPaper00052269
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    WBPaper00057894
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    WBPaper00061470
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    WBPaper00063445
    WBPaper00064107
    WBPaper00064339
    WBPaper00064788
    WBPaper00065149
    WBPaper00065308
    WBPaper00065651
  Picture: WBPicture0000013091
  Method: Gene