WormBase Tree Display for Gene: WBGene00000536

WBGene00000536 Evidence: Paper_evidence: WBPaper00013270
  SMap: S_parent: Sequence: ZC395
  Identity: Version: 1
    Name: CGC_name: clk-1 Person_evidence: WBPerson247
      Sequence_name: ZC395.2
      Molecular_name (3)
      Other_name: coq-7 CGC_data_submission
        coq-1
        CELE_ZC395.2 Accession_evidence: NDB BX284603
      Public_name: clk-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:21 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: clk
    Allele (17)
    Legacy_information: [Hekimi S] Phenotype is slow growth. Strong maternal rescue of M+ Z- worms. Zygotically rescued. clk-1(qm30) worms are viable at 20C but become sterile at 25C.
      [Hekimi S] e2519mat growth and behavior slowed by up to 2-fold. Profound zygotic and maternal rescue. Slow postembryonic development, slow cell cycle, long life span. Swimming, pumping, egg-laying, defecation all slow and irregular. OA4- qm30 (worms are viable at 20C but become sterile at 25C)
      [C.elegansII] e2519mat : growth and behavior slowed by up to 2-fold.Profound zygotic and maternal rescue.Slow postembryonic development, slow cell cycle,long life span. Swimming, pumping, egg-laying, defecation all slow and irregular. OA4: qm30 (worms are viable at 20C but become sterile at 25C) qm11, qm47, qm51. Cloned: cosmid rescue (W03B11)[Wong et al. 1995]
    Strain (11)
    RNASeq_FPKM (74)
    GO_annotation (67)
    Contained_in_operon: CEOP3280
    Ortholog (34)
    Structured_description: Concise_description: clk-1 encodes the C. elegans ortholog of COQ7/CAT5, a highly conserved demethoxyubiquinone (DMQ) hydroxylase that is necessary for the biosynthesis of ubiquinone (coenzyme Q, Q9) from 5-demethoxyubiquinone (DMQ9); in C. elegans, CLK-1 activity is required for normal physiological rates of growth, development, behavior, and aging, as well as for normal brood sizes. Paper_evidence: WBPaper00004595
            WBPaper00006240
            WBPaper00027358
          Curator_confirmed: WBPerson1843
            WBPerson567
          Date_last_updated: 09 Jul 2007 00:00:00
      Automated_description: Enables transcription cis-regulatory region binding activity. Involved in several processes, including determination of adult lifespan; positive regulation of multicellular organismal process; and regulation of macromolecule metabolic process. Located in mitochondrion and nucleus. Expressed widely. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 8. Is an ortholog of human COQ7 (coenzyme Q7, hydroxylase). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0070245 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2244)
      EFO:MONDO:0015363 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:2244)
  Molecular_info: Corresponding_CDS: ZC395.2
    Corresponding_transcript: ZC395.2.1
    Other_sequence (43)
    Associated_feature: WBsf224906
      WBsf224907
  Experimental_info (11)
  Map_info: Map: III Position: -1.84679 Error: 0.003094
    Well_ordered
    Positive: Inside_rearr: sDp3
      Positive_clone: ZC395 Inferred_automatically: From sequence, transcript, pseudogene data
        ZC400 Person_evidence: WBPerson168
    Mapping_data (3)
  Reference: WBPaper00002127
    WBPaper00002340
    WBPaper00002455
    WBPaper00002456
    WBPaper00002486
    WBPaper00002488
    WBPaper00002496
    WBPaper00002499
    WBPaper00002578
    WBPaper00002651
    WBPaper00002657
    WBPaper00002658
    WBPaper00002732
    WBPaper00002792
    WBPaper00002867
    WBPaper00002975
    WBPaper00003243
    WBPaper00003257
    WBPaper00003260
    WBPaper00003333
    WBPaper00003475
    WBPaper00003496
    WBPaper00003527
    WBPaper00003534
    WBPaper00003640
    WBPaper00003689
    WBPaper00003793
    WBPaper00003872
    WBPaper00003876
    WBPaper00004217
    WBPaper00004218
    WBPaper00004252
    WBPaper00004266
    WBPaper00004374
    WBPaper00004398
    WBPaper00004425
    WBPaper00004511
    WBPaper00004516
    WBPaper00004541
    WBPaper00004595
    WBPaper00004606
    WBPaper00004804
    WBPaper00004845
    WBPaper00004896
    WBPaper00004898
    WBPaper00004913
    WBPaper00004957
    WBPaper00005018
    WBPaper00005024
    WBPaper00005034
    WBPaper00005038
    WBPaper00005078
    WBPaper00005133
    WBPaper00005205
    WBPaper00005206
    WBPaper00005207
    WBPaper00005211
    WBPaper00005217
    WBPaper00005228
    WBPaper00005271
    WBPaper00005333
    WBPaper00005389
    WBPaper00005442
    WBPaper00005534
    WBPaper00005593
    WBPaper00005624
    WBPaper00005659
    WBPaper00005690
    WBPaper00005715
    WBPaper00005817
    WBPaper00005863
    WBPaper00005892
    WBPaper00005894
    WBPaper00005895
    WBPaper00005902
    WBPaper00006068
    WBPaper00006103
    WBPaper00006155
    WBPaper00006232
    WBPaper00006240
    WBPaper00006261
    WBPaper00006278
    WBPaper00006360
    WBPaper00006515
    WBPaper00010277
    WBPaper00010359
    WBPaper00010566
    WBPaper00011038
    WBPaper00011041
    WBPaper00011135
    WBPaper00011231
    WBPaper00011299
    WBPaper00012549
    WBPaper00012913
    WBPaper00013453
    WBPaper00015268
    WBPaper00015392
    WBPaper00015440
    WBPaper00015581
    WBPaper00015771
    WBPaper00016841
    WBPaper00016850
    WBPaper00016869
    WBPaper00016937
    WBPaper00017025
    WBPaper00017158
    WBPaper00017902
    WBPaper00017904
    WBPaper00017922
    WBPaper00017923
    WBPaper00017924
    WBPaper00017925
    WBPaper00018575
    WBPaper00018757
    WBPaper00018857
    WBPaper00018895
    WBPaper00019097
    WBPaper00019108
    WBPaper00019114
    WBPaper00019158
    WBPaper00020820
    WBPaper00021761
    WBPaper00021821
    WBPaper00021890
    WBPaper00022269
    WBPaper00022373
    WBPaper00022476
    WBPaper00022484
    WBPaper00022578
    WBPaper00022922
    WBPaper00022923
    WBPaper00023012
    WBPaper00023014
    WBPaper00023066
    WBPaper00023235
    WBPaper00024204
    WBPaper00024266
    WBPaper00024283
    WBPaper00024392
    WBPaper00024513
    WBPaper00024668
    WBPaper00024709
    WBPaper00024710
    WBPaper00024712
    WBPaper00024755
    WBPaper00024892
    WBPaper00024947
    WBPaper00024968
    WBPaper00024991
    WBPaper00025004
    WBPaper00025195
    WBPaper00025291
    WBPaper00025407
    WBPaper00025408
    WBPaper00025662
    WBPaper00025668
    WBPaper00025691
    WBPaper00025727
    WBPaper00025859
    WBPaper00026045
    WBPaper00026643
    WBPaper00026674
    WBPaper00026870
    WBPaper00027130
    WBPaper00027157
    WBPaper00027283
    WBPaper00027338
    WBPaper00027358
    WBPaper00027486
    WBPaper00027771
    WBPaper00028372
    WBPaper00028394
    WBPaper00028420
    WBPaper00028429
    WBPaper00028634
    WBPaper00028954
    WBPaper00029007
    WBPaper00029088
    WBPaper00029124
    WBPaper00029158
    WBPaper00029409
    WBPaper00029422
    WBPaper00031044
    WBPaper00031120
    WBPaper00031132
    WBPaper00031241
    WBPaper00031319
    WBPaper00031326
    WBPaper00031376
    WBPaper00031459
    WBPaper00031509
    WBPaper00031528
    WBPaper00031896
    WBPaper00031942
    WBPaper00032175
    WBPaper00032574
    WBPaper00032605
    WBPaper00032740
    WBPaper00032884
    WBPaper00032929
    WBPaper00032932
    WBPaper00033065
    WBPaper00033133
    WBPaper00033134
    WBPaper00033158
    WBPaper00033162
    WBPaper00033449
    WBPaper00033678
    WBPaper00034694
    WBPaper00035066
    WBPaper00035230
    WBPaper00035297
    WBPaper00035402
    WBPaper00035483
    WBPaper00035659
    WBPaper00036073
    WBPaper00036249
    WBPaper00036334
    WBPaper00036513
    WBPaper00037434
    WBPaper00037471
    WBPaper00037826
    WBPaper00038082
    WBPaper00038186
    WBPaper00038379
    WBPaper00038491
    WBPaper00039607
    WBPaper00039867
    WBPaper00040525
    WBPaper00040902
    WBPaper00040976
    WBPaper00041077
    WBPaper00041212
    WBPaper00041233
    WBPaper00041370
    WBPaper00041408
    WBPaper00041750
    WBPaper00041882
    WBPaper00042133
    WBPaper00042375
    WBPaper00042382
    WBPaper00042459
    WBPaper00043081
    WBPaper00043122
    WBPaper00044730
    WBPaper00045628
    WBPaper00045774
    WBPaper00045829
    WBPaper00046210
    WBPaper00046337
    WBPaper00046575
    WBPaper00046671
    WBPaper00046740
    WBPaper00046786
    WBPaper00047022
    WBPaper00047057
    WBPaper00047601
    WBPaper00047612
    WBPaper00047630
    WBPaper00047662
    WBPaper00047832
    WBPaper00048171
    WBPaper00048667
    WBPaper00049781
    WBPaper00050026
    WBPaper00050325
    WBPaper00050434
    WBPaper00051094
    WBPaper00051665
    WBPaper00051708
    WBPaper00051842
    WBPaper00053133
    WBPaper00053810
    WBPaper00054411
    WBPaper00054769
    WBPaper00055090
    WBPaper00055153
    WBPaper00055188
    WBPaper00055941
    WBPaper00057523
    WBPaper00057712
    WBPaper00059470
    WBPaper00059531
    WBPaper00060692
    WBPaper00060884
    WBPaper00061072
    WBPaper00061178
    WBPaper00061251
    WBPaper00061260
    WBPaper00061418
    WBPaper00061745
    WBPaper00061852
    WBPaper00062293
    WBPaper00062418
    WBPaper00062518
    WBPaper00062529
    WBPaper00062730
    WBPaper00062806
    WBPaper00063165
    WBPaper00064272
    WBPaper00064339
    WBPaper00064568
    WBPaper00064908
    WBPaper00065937
    WBPaper00066067
    WBPaper00066329
  Remark: [Ewbank J] Cloned: cosmid rescue (W03B11)" is false;ZC395 gives cosmid rescue
  Method: Gene