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WormBase Tree Display for Gene: WBGene00003020

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Name Class

WBGene00003020SMapS_parentSequenceC32F10
IdentityVersion1
NameCGC_namelin-35Person_evidenceWBPerson261
Sequence_nameC32F10.2
Molecular_nameC32F10.2
C32F10.2.1
CE24823
Other_nameCELE_C32F10.2Accession_evidenceNDBBX284601
Public_namelin-35
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:30WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classlin
Allele (104)
Legacy_informationn745 : wildtype alone Muv in homozygotes with lin-8 lin-38 or lin-15(n767). ES2. NA2 (n373 (similar phenotype)).
See also n373, n745
[C.elegansII] n745 : almost WT alone (reduced fertility); Muv (extra vulval differentiation) in homozygotes with lin-8, lin-38 or lin-15(n767). ES2. OA1: n373 (similar). [Ferguson and Horvitz 1989; MT; PS]
Strain (17)
Component_of_genotypeWBGenotype00000009
RNASeq_FPKM (74)
GO_annotation (50)
Ortholog (43)
Structured_descriptionConcise_descriptionlin-35 encodes the C. elegans retinoblastoma protein (Rb) ortholog; lin-35 was first identified in screens for synthetic multivulva (synMuv) genes and as a class B synMuv gene, functions redundantly with class A genes to antagonize Ras signaling and negatively regulate vulval development; in addition, loss of lin-35 activity results in enhanced RNA interference; lin-35 activity is also required redundantly with: 1) pha-1 and ubc-18 for early steps in pharyngeal morphogenesis, 2) fzr-1 for normal patterns of postembryonic proliferation, 3) xnp-1 for somatic gonad development, and 4) psa-1 for fertility and embryonic and larval development; on its own, lin-35 is also required for wild-type levels of fertility; LIN-35 is expressed broadly in embryos and L1 larvae, but in later larvae and adults is detected in vulval precursor cells and their descendants as well as a subset of head and tail cells.Paper_evidenceWBPaper00003329
WBPaper00004635
WBPaper00005137
WBPaper00005931
WBPaper00024215
WBPaper00024320
WBPaper00024322
WBPaper00024692
WBPaper00027135
Curator_confirmedWBPerson1843
WBPerson567
Date_last_updated05 May 2009 00:00:00
Automated_descriptionPredicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of cell cycle; negative regulation of vulval development; and positive regulation of brood size. Located in nucleus. Expressed in several structures, including head and tail. Used to study intellectual disability. Human ortholog(s) of this gene implicated in several diseases, including germ cell cancer (multiple); high grade glioma (multiple); and urinary system cancer (multiple). Is an ortholog of human RBL1 (RB transcriptional corepressor like 1) and RBL2 (RB transcriptional corepressor like 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:1059Homo sapiensPaper_evidenceWBPaper00024322
Accession_evidenceOMIM309580
Curator_confirmedWBPerson324
Date_last_updated18 Apr 2013 00:00:00
Potential_model (16)
Disease_relevanceHuman ATRX encodes a protein with a ATPase/helicase domain involved in chromatin remodeling, mutations in which, have been associated with alpha-thalassemia and X-linked mental retardation; the elegans ortholog, xnp-1 is required for gonadal development and acts in association with lin-35/Retinoblastoma (RB), components of the NuRD complex and hpl-2/HP1 genes; the requirement of xnp-1 with lin-35/ Rb in larval development in C. elegans can be compared with the observation that in humans, XNP/ATR-X mutation is also associated, with short stature and skeletal abnormalities during development.Homo sapiensPaper_evidenceWBPaper00024322
WBPaper00024692
WBPaper00003646
Curator_confirmedWBPerson324
Date_last_updated23 Apr 2013 00:00:00
Models_disease_assertedWBDOannot00000614
WBDOannot00001021
Molecular_infoCorresponding_CDSC32F10.2
Corresponding_transcriptC32F10.2.1
Associated_featureWBsf643315
WBsf643316
WBsf656335
WBsf656336
WBsf656337
WBsf656338
WBsf983774
WBsf217712
Gene_product_binds (376)
Transcription_factorWBTranscriptionFactor000270
Experimental_infoRNAi_resultWBRNAi00093084Inferred_automaticallyRNAi_primary
WBRNAi00063017Inferred_automaticallyRNAi_primary
WBRNAi00024705Inferred_automaticallyRNAi_primary
WBRNAi00069979Inferred_automaticallyRNAi_primary
WBRNAi00008203Inferred_automaticallyRNAi_primary
WBRNAi00097562Inferred_automaticallyRNAi_primary
WBRNAi00063034Inferred_automaticallyRNAi_primary
WBRNAi00085988Inferred_automaticallyRNAi_primary
WBRNAi00097563Inferred_automaticallyRNAi_primary
WBRNAi00065492Inferred_automaticallyRNAi_primary
WBRNAi00092382Inferred_automaticallyRNAi_primary
WBRNAi00063040Inferred_automaticallyRNAi_primary
WBRNAi00063016Inferred_automaticallyRNAi_primary
WBRNAi00063035Inferred_automaticallyRNAi_primary
WBRNAi00086698Inferred_automaticallyRNAi_primary
WBRNAi00087226Inferred_automaticallyRNAi_primary
WBRNAi00078279Inferred_automaticallyRNAi_primary
WBRNAi00067833Inferred_automaticallyRNAi_primary
WBRNAi00024706Inferred_automaticallyRNAi_primary
WBRNAi00111896Inferred_automaticallyRNAi_primary
WBRNAi00024704Inferred_automaticallyRNAi_primary
WBRNAi00075367Inferred_automaticallyRNAi_primary
WBRNAi00063025Inferred_automaticallyRNAi_primary
WBRNAi00075395Inferred_automaticallyRNAi_primary
WBRNAi00075370Inferred_automaticallyRNAi_primary
WBRNAi00086547Inferred_automaticallyRNAi_primary
WBRNAi00078288Inferred_automaticallyRNAi_primary
WBRNAi00094011Inferred_automaticallyRNAi_primary
WBRNAi00086811Inferred_automaticallyRNAi_primary
WBRNAi00063047Inferred_automaticallyRNAi_primary
WBRNAi00078520Inferred_automaticallyRNAi_primary
WBRNAi00075397Inferred_automaticallyRNAi_primary
WBRNAi00063046Inferred_automaticallyRNAi_primary
WBRNAi00078521Inferred_automaticallyRNAi_primary
WBRNAi00061272Inferred_automaticallyRNAi_primary
WBRNAi00065493Inferred_automaticallyRNAi_primary
WBRNAi00063015Inferred_automaticallyRNAi_primary
WBRNAi00064588Inferred_automaticallyRNAi_primary
WBRNAi00085986Inferred_automaticallyRNAi_primary
WBRNAi00064651Inferred_automaticallyRNAi_primary
WBRNAi00087224Inferred_automaticallyRNAi_primary
WBRNAi00086398Inferred_automaticallyRNAi_primary
WBRNAi00116545Inferred_automaticallyRNAi_primary
WBRNAi00097561Inferred_automaticallyRNAi_primary
WBRNAi00061264Inferred_automaticallyRNAi_primary
WBRNAi00041697Inferred_automaticallyRNAi_primary
WBRNAi00067195Inferred_automaticallyRNAi_primary
WBRNAi00061262Inferred_automaticallyRNAi_primary
WBRNAi00067744Inferred_automaticallyRNAi_primary
WBRNAi00063018Inferred_automaticallyRNAi_primary
WBRNAi00085987Inferred_automaticallyRNAi_primary
WBRNAi00075369Inferred_automaticallyRNAi_primary
WBRNAi00061231Inferred_automaticallyRNAi_primary
WBRNAi00086546Inferred_automaticallyRNAi_primary
WBRNAi00075371Inferred_automaticallyRNAi_primary
WBRNAi00091419Inferred_automaticallyRNAi_primary
WBRNAi00088933Inferred_automaticallyRNAi_primary
WBRNAi00087225Inferred_automaticallyRNAi_primary
WBRNAi00061230Inferred_automaticallyRNAi_primary
WBRNAi00068068Inferred_automaticallyRNAi_primary
WBRNAi00075368Inferred_automaticallyRNAi_primary
WBRNAi00003064Inferred_automaticallyRNAi_primary
WBRNAi00063024Inferred_automaticallyRNAi_primary
WBRNAi00086399Inferred_automaticallyRNAi_primary
WBRNAi00027861Inferred_automaticallyRNAi_primary
WBRNAi00086812Inferred_automaticallyRNAi_primary
WBRNAi00065490Inferred_automaticallyRNAi_primary
WBRNAi00094225Inferred_automaticallyRNAi_primary
WBRNAi00092383Inferred_automaticallyRNAi_primary
WBRNAi00069932Inferred_automaticallyRNAi_primary
WBRNAi00113522Inferred_automaticallyRNAi_primary
WBRNAi00092379Inferred_automaticallyRNAi_primary
WBRNAi00097560Inferred_automaticallyRNAi_primary
WBRNAi00078204Inferred_automaticallyRNAi_primary
WBRNAi00086699Inferred_automaticallyRNAi_primary
WBRNAi00075396Inferred_automaticallyRNAi_primary
WBRNAi00062684Inferred_automaticallyRNAi_primary
WBRNAi00069995Inferred_automaticallyRNAi_primary
Expr_patternChronogram622
Expr1291
Expr3128
Expr1015789
Expr1031411
Expr1145718
Expr2013177
Expr2031409
Drives_constructWBCnstr00004066
WBCnstr00006281
WBCnstr00011156
WBCnstr00017294
WBCnstr00036281
Construct_productWBCnstr00006281
WBCnstr00011156
WBCnstr00017287
WBCnstr00017294
WBCnstr00017295
WBCnstr00017296
WBCnstr00021077
WBCnstr00021078
WBCnstr00021079
WBCnstr00036281
Regulate_expr_cluster (16)
Antibody (4)
Microarray_results (20)
Expression_cluster (156)
Interaction (322)
Product_binds_matrixWBPmat00005534
WBPmat00005535
WBPmat00005536
WBPmat00005540
WBPmat00005541
WBPmat00005542
WBPmat00005543
WBPmat00005544
WBPmat00005545
Map_infoMapIPosition0.461719Error0.000997
Well_ordered
PositivePositive_cloneC32F10Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point283
308
309
4517
Reference (253)
PictureWBPicture0000013091
MethodGene