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WormBase Tree Display for Gene: WBGene00006915

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Name Class

WBGene00006915SMapS_parentSequenceCHROMOSOME_II
IdentityVersion1
NameCGC_namevha-6
Sequence_nameVW02B12L.1
Molecular_nameVW02B12L.1
VW02B12L.1.1
CE18980
Other_nameCELE_VW02B12L.1Accession_evidenceNDBBX284602
Public_namevha-6
DB_infoDatabase (11)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:43WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classvha
Allele (54)
Legacy_information[Pujol N] vha-6 is expressed only in the intestine, from the embryonic coma stage through larvae and adult
StrainWBStrain00036524
RNASeq_FPKM (74)
GO_annotation (17)
Ortholog (58)
ParalogWBGene00006768Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006914Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006916Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionvha-6 encodes an ortholog of subunit a of the membrane-bound (V0) domainof vacuolar proton-translocating ATPase (V-ATPase); VHA-6 is orthologousto human ATP6N1A (OMIM:192130), ATP6V0A2, ATP6V0A4 (OMIM:605239, mutatedin distal renal tubular acidosis), and TCIRG1 (OMIM:604592, mutated inosteopetrosis); VHA-6 is expressed in germline (P2 through Z3 cellsuntil the comma stage), on the apical surface of postembryonicintestinal cells, and at the junction between pharynx and intestine;VHA-6 is required for growth and survival past the L1 larval stage;vha-6(RNAi) animals arrest as L1 larvae and remain alive (but do notgrow) for one week; in S. cerevisiae, different V0 a-subunits (Stv1p andVph1p) direct the assembly of V-ATPases to different membranes andorganelles, suggesting that the profusion of such subunits in C. elegans(co-orthologous VHA-5, VHA-6, VHA-7, and six UNC-32 isoforms) may have asimilar function; VHA-6 is predicted to capture protons from V-ATPasetransmembrane rotor components and export the protons across themembrane.Paper_evidenceWBPaper00004601
WBPaper00004842
WBPaper00025183
WBPaper00028773
WBPaper00028774
WBPaper00028775
Curator_confirmedWBPerson567
Date_last_updated19 Nov 2006 00:00:00
Automated_descriptionPredicted to enable ATPase binding activity. Involved in nematode larval development. Located in apical plasma membrane. Part of vacuolar proton-transporting V-type ATPase complex. Expressed in Psub2; excretory cell; hypodermis; pharyngeal-intestinal valve; and uterus. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive cutis laxa type IIA; autosomal recessive osteopetrosis 1; and developmental and epileptic encephalopathy 104. Is an ortholog of several human genes including ATP6V0A1 (ATPase H+ transporting V0 subunit a1); ATP6V0A2 (ATPase H+ transporting V0 subunit a2); and TCIRG1 (T cell immune regulator 1, ATPase H+ transporting V0 subunit a3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoPotential_modelDOID:0070390Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:865)
DOID:0110942Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11647)
DOID:14219Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:866)
DOID:0112171Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18481)
EFO:MONDO:0015827Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:866)
DOID:0070134Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:18481)
Molecular_infoCorresponding_CDSVW02B12L.1
Corresponding_transcriptVW02B12L.1.1
Other_sequence (71)
Associated_featureWBsf650573
WBsf650574
WBsf989758
WBsf1013237
WBsf223933
Experimental_infoRNAi_resultWBRNAi00096854Inferred_automaticallyRNAi_primary
WBRNAi00066248Inferred_automaticallyRNAi_primary
WBRNAi00096665Inferred_automaticallyRNAi_primary
WBRNAi00106143Inferred_automaticallyRNAi_primary
WBRNAi00096804Inferred_automaticallyRNAi_primary
WBRNAi00096808Inferred_automaticallyRNAi_primary
WBRNAi00066220Inferred_automaticallyRNAi_primary
WBRNAi00096217Inferred_automaticallyRNAi_primary
WBRNAi00096805Inferred_automaticallyRNAi_primary
WBRNAi00106557Inferred_automaticallyRNAi_primary
WBRNAi00008348Inferred_automaticallyRNAi_primary
WBRNAi00106529Inferred_automaticallyRNAi_primary
WBRNAi00095988Inferred_automaticallyRNAi_primary
WBRNAi00066254Inferred_automaticallyRNAi_primary
WBRNAi00066174Inferred_automaticallyRNAi_primary
WBRNAi00009235Inferred_automaticallyRNAi_primary
WBRNAi00096803Inferred_automaticallyRNAi_primary
WBRNAi00106078Inferred_automaticallyRNAi_primary
WBRNAi00096294Inferred_automaticallyRNAi_primary
WBRNAi00111095Inferred_automaticallyRNAi_primary
WBRNAi00096744Inferred_automaticallyRNAi_primary
WBRNAi00096599Inferred_automaticallyRNAi_primary
WBRNAi00102727Inferred_automaticallyRNAi_primary
WBRNAi00096837Inferred_automaticallyRNAi_primary
WBRNAi00066281Inferred_automaticallyRNAi_primary
WBRNAi00090912Inferred_automaticallyRNAi_primary
WBRNAi00096722Inferred_automaticallyRNAi_primary
WBRNAi00106512Inferred_automaticallyRNAi_primary
WBRNAi00096666Inferred_automaticallyRNAi_primary
WBRNAi00065030Inferred_automaticallyRNAi_primary
WBRNAi00095911Inferred_automaticallyRNAi_primary
WBRNAi00096664Inferred_automaticallyRNAi_primary
WBRNAi00036121Inferred_automaticallyRNAi_primary
WBRNAi00096868Inferred_automaticallyRNAi_primary
WBRNAi00096771Inferred_automaticallyRNAi_primary
WBRNAi00096862Inferred_automaticallyRNAi_primary
WBRNAi00096140Inferred_automaticallyRNAi_primary
WBRNAi00096596Inferred_automaticallyRNAi_primary
WBRNAi00096806Inferred_automaticallyRNAi_primary
WBRNAi00070603Inferred_automaticallyRNAi_primary
WBRNAi00054473Inferred_automaticallyRNAi_primary
WBRNAi00026433Inferred_automaticallyRNAi_primary
WBRNAi00095749Inferred_automaticallyRNAi_primary
WBRNAi00096724Inferred_automaticallyRNAi_primary
WBRNAi00096743Inferred_automaticallyRNAi_primary
WBRNAi00096745Inferred_automaticallyRNAi_primary
WBRNAi00096809Inferred_automaticallyRNAi_primary
WBRNAi00096726Inferred_automaticallyRNAi_primary
WBRNAi00096801Inferred_automaticallyRNAi_primary
WBRNAi00096802Inferred_automaticallyRNAi_primary
WBRNAi00066302Inferred_automaticallyRNAi_primary
WBRNAi00096773Inferred_automaticallyRNAi_primary
WBRNAi00096799Inferred_automaticallyRNAi_primary
WBRNAi00096063Inferred_automaticallyRNAi_primary
WBRNAi00096807Inferred_automaticallyRNAi_primary
Expr_patternExpr851
Expr2404
Expr2407
Expr13465
Expr1029215
Expr1032932
Expr1158019
Expr2017992
Expr2036128
Drives_construct (205)
Construct_productWBCnstr00013297
WBCnstr00016253
WBCnstr00038389
AntibodyWBAntibody00000406
Microarray_results (20)
Expression_cluster (230)
Interaction (123)
Map_infoMapIIPosition3.46558Error0.000297
PositivePositive_cloneVW02B12LInferred_automaticallyFrom CDS info
From sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00004842
WBPaper00005295
WBPaper00005567
WBPaper00010347
WBPaper00029254
WBPaper00034480
WBPaper00035048
WBPaper00035182
WBPaper00036098
WBPaper00036578
WBPaper00036659
WBPaper00038491
WBPaper00046899
WBPaper00055090
WBPaper00057684
WBPaper00058161
WBPaper00058835
WBPaper00058870
WBPaper00059755
WBPaper00061730
WBPaper00062454
WBPaper00064023
WBPaper00064130
WBPaper00064187
WBPaper00064204
WBPaper00064229
WBPaper00064708
WBPaper00064933
RemarkSequence From: Pujol Nathalie via ACEDB feedback page <pujol@lgpd.univ-mrs.fr>
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene