pgam-5 encodes a phosphoglycerate mutase that uses alternate catalytic activity as a protein serine/threonine phosphatase; PGAM-5 physically interacts with the SKN-1 transcription factor in a directed yeast two-hybrid assay as well as in vitro coimmunoprecipitation studies; based on sequence similarity, PGAM-5 is predicted to be a mitochondrial outer membrane protein.
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in positive regulation of mitochondrial fission. Predicted to be located in mitochondrion. Expressed in neurons and pharynx. Is an ortholog of human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.
CGC_data_submission
[200225 pad] Modified Map position as it was a reverse physical that could not be fixed by automated methods. (0.5048)