gstk-1 encodes one of two C. elegans kappa class glutathione transferases; while gstk-1(RNAi) animals exhibit no obvious developmental or morphological abnormalities, animals doubly mutant for gstk-1 and gstk-2 exhibit decreased respiration and a lower concentration of the monounsaturated fatty acid cis-vaccenic acid; GSTK-1 is expressed in the intestine, body wall muscle, and epidermis and localizes to peroxisomes.
Predicted to enable glutathione peroxidase activity and glutathione transferase activity. Involved in innate immune response. Located in peroxisome. Expressed in body wall musculature; hypodermis; and rectal gland cell. Is an ortholog of human GSTK1 (glutathione S-transferase kappa 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.