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WormBase Tree Display for Gene: WBGene00001949

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Name Class

WBGene00001949SMapS_parentSequenceCHROMOSOME_I
IdentityVersion1
NameCGC_namehlh-2Person_evidenceWBPerson346
Sequence_nameM05B5.5
Molecular_nameM05B5.5a
M05B5.5a.1
CE06191
M05B5.5b
Other_nameCELE_M05B5.5Accession_evidenceNDBBX284601
Public_namehlh-2
DB_infoDatabase (12)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:26WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classhlh
Allele (33)
Possibly_affected_byWBVar02154068
Legacy_information[C.elegansII] NMK. Encodes homolog of vertebrate E12, Drosophila daughterless. lacZ fusion indicates transcription in some neuronal precursors. Antibody staining indicates all blastomere nuclei stain up to 200-cell stage, later expression complex, strong in head, ventral cord and tail at comma stage; fewer than 20 cells stain at hatching. Cosmid K07G5. [KM]
[Portman DS] bx108 and bx115 enhance the male tail ray-loss phenotype of lin-32 alleles, but have no noticeable phenotype in a wild-type background
StrainWBStrain00022642
WBStrain00027596
WBStrain00007182
WBStrain00007186
WBStrain00047282
WBStrain00047249
RNASeq_FPKMWBls:0000002 (84)
WBls:0000003 (11)
WBls:0000004 (47)
WBls:000000653.6713From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000006.Hermaphrodite.WBbt:0007833.SRP042619.SRX559705
RNASeq.elegans.WBStrain00000001.WBls:0000006.Hermaphrodite.WBbt:0007833.SRP042619.SRX559706
WBls:0000007 (11)
WBls:000000813.0646From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX085219
41.7276From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX145480
44.4359From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000008.Hermaphrodite.WBbt:0007833.SRP000401.SRX085220
WBls:0000010 (15)
WBls:0000013 (11)
WBls:0000014 (19)
WBls:0000015 (24)
WBls:00000170.397264From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343252
171.924From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004458.SRP029448.SRX343278
1e-10From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343253
RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004804.SRP029448.SRX343254
RNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0008115.SRP029448.SRX343342
2.33069From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0003810.SRP029448.SRX343324
28.8586From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004015.SRP029448.SRX343305
35.254From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004015.SRP029448.SRX343304
36.4489From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0003810.SRP029448.SRX343325
52.968From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000017.Hermaphrodite.WBbt:0004458.SRP029448.SRX343277
WBls:0000020 (16)
WBls:0000021 (19)
WBls:00000230.0796659From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000023.Hermaphrodite.WBbt:0007833.SRP015688.SRX185639
WBls:0000024 (68)
WBls:0000027 (15)
WBls:000003111.4625From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103276
3.8291From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103273
5.15445From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX047470
5.88074From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX008139
5.94344From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103274
6.30414From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103277
8.42905From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000031.Hermaphrodite.WBbt:0007833.SRP000401.SRX103275
WBls:00000324.69933From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103985
5.05724From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103984
5.06949From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX008138
5.49539From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019178
5.6094From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP000401.SRX103983
6.13021From_analysisRNASeq.elegans.WBls:0000032.control_mean
RNASeq.elegans.WBls:0000032.control_median
6.76503From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000032.Hermaphrodite.WBbt:0007833.SRP058023.SRX1019179
WBls:0000035 (31)
WBls:0000038 (85)
WBls:0000041 (29)
WBls:00000521.48743From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX008140
3.16126From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX037199
4.81441From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103278
5.03329From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103269
5.3376From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103280
5.85279From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103279
6.14739From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103270
6.28106From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103272
7.26803From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103271
7.31219From_analysisRNASeq.elegans.WBStrain00004309.WBls:0000052.Hermaphrodite.WBbt:0007833.SRP000401.SRX103281
WBls:0000063 (103)
WBls:0000064 (14)
WBls:0000065 (16)
WBls:000006833.8874From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265364
38.703From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265365
40.3804From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265363
42.922From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265362
43.3548From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265360
43.5983From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000068.Hermaphrodite.WBbt:0007833.SRP021083.SRX265361
WBls:0000131115.853From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343228
16.4258From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006771.SRP029448.SRX343225
30.067From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343221
30.4349From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006771.SRP029448.SRX343226
36.3512From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343223
38.0939From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0006876.SRP029448.SRX343222
68.7261From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343229
78.5994From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343220
84.2158From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000131.Hermaphrodite.WBbt:0004015.SRP029448.SRX343227
WBls:000014198.1793From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000141.Hermaphrodite.WBbt:0007833.SRP029448.SRX343161
WBls:0000151 (14)
WBls:0000171 (15)
WBls:0000181162.778From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000181.Hermaphrodite.WBbt:0007833.SRP029448.SRX343164
WBls:0000191140.737From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000191.Hermaphrodite.WBbt:0007833.SRP029448.SRX343165
WBls:0000201 (12)
WBls:000022111.7491From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343265
118.058From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0008115.SRP029448.SRX343334
126.499From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004015.SRP029448.SRX343291
239.428From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004015.SRP029448.SRX343290
32.6694From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0003810.SRP029448.SRX343315
33.847From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343264
62.711From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0008115.SRP029448.SRX343333
72.1248From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004458.SRP029448.SRX343266
85.6887From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0003810.SRP029448.SRX343314
87.5001From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000221.Hermaphrodite.WBbt:0004804.SRP029448.SRX343241
WBls:0000231160.042From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000231.Hermaphrodite.WBbt:0007833.SRP029448.SRX343167
WBls:0000251139.393From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004015.SRP029448.SRX343292
162.923From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343335
1e-10From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343242
RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343243
RNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343336
228.326From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0007833.SRP029448.SRX343168
26.6257From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004804.SRP029448.SRX343244
43.7783From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0008115.SRP029448.SRX343337
67.2361From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0003810.SRP029448.SRX343317
77.5014From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000251.Hermaphrodite.WBbt:0004458.SRP029448.SRX343268
WBls:0000261253.955From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000261.Hermaphrodite.WBbt:0007833.SRP029448.SRX343169
WBls:0000281213.348From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000281.Hermaphrodite.WBbt:0007833.SRP029448.SRX343170
WBls:0000291 (12)
WBls:0000301196.294From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000301.Hermaphrodite.WBbt:0007833.SRP029448.SRX343172
WBls:0000311256.09From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000311.Hermaphrodite.WBbt:0007833.SRP029448.SRX343173
WBls:0000321205.407From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000321.Hermaphrodite.WBbt:0007833.SRP029448.SRX343174
WBls:0000331143.652From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000331.Hermaphrodite.WBbt:0007833.SRP029448.SRX343176
183.055From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000331.Hermaphrodite.WBbt:0007833.SRP029448.SRX343175
WBls:0000351188.748From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000351.Hermaphrodite.WBbt:0007833.SRP029448.SRX343179
209.231From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000351.Hermaphrodite.WBbt:0007833.SRP029448.SRX343178
WBls:0000361229.728From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000361.Hermaphrodite.WBbt:0007833.SRP029448.SRX343180
WBls:00003810.518702From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343249
0.690925From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343248
107.116From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0003810.SRP029448.SRX343320
193.739From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004458.SRP029448.SRX343275
195.561From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004458.SRP029448.SRX343274
2.94203From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004804.SRP029448.SRX343250
32.6722From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0008115.SRP029448.SRX343340
87.9563From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004015.SRP029448.SRX343297
91.5856From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000381.Hermaphrodite.WBbt:0004015.SRP029448.SRX343299
WBls:0000391199.726From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000391.Hermaphrodite.WBbt:0007833.SRP029448.SRX343181
WBls:0000401180.241From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000401.Hermaphrodite.WBbt:0007833.SRP029448.SRX343182
WBls:0000421203.11From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000421.Hermaphrodite.WBbt:0007833.SRP029448.SRX343184
WBls:0000431223.148From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000431.Hermaphrodite.WBbt:0007833.SRP029448.SRX343185
WBls:0000451198.406From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000451.Hermaphrodite.WBbt:0007833.SRP029448.SRX343186
WBls:0000461186.863From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000461.Hermaphrodite.WBbt:0007833.SRP029448.SRX343187
WBls:0000471118.912From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343302
154.266From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343301
159.995From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004458.SRP029448.SRX343276
35.7515From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0008115.SRP029448.SRX343341
374.607From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004015.SRP029448.SRX343300
6.36488From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0004804.SRP029448.SRX343251
77.9417From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000471.Hermaphrodite.WBbt:0007833.SRP029448.SRX343189
WBls:0000491103.929From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000491.Hermaphrodite.WBbt:0007833.SRP029448.SRX343191
WBls:000050150.8262From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000501.Hermaphrodite.WBbt:0007833.SRP029448.SRX343192
WBls:000051141.8317From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000511.Hermaphrodite.WBbt:0007833.SRP029448.SRX343194
WBls:000052118.6369From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000521.Hermaphrodite.WBbt:0007833.SRP029448.SRX343195
WBls:000053120.1999From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000531.Hermaphrodite.WBbt:0007833.SRP029448.SRX343197
28.0283From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000531.Hermaphrodite.WBbt:0007833.SRP029448.SRX343196
WBls:000054114.9809From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000541.Hermaphrodite.WBbt:0007833.SRP029448.SRX343199
23.2061From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000541.Hermaphrodite.WBbt:0007833.SRP029448.SRX343198
WBls:000055124.772From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000551.Hermaphrodite.WBbt:0007833.SRP029448.SRX343200
WBls:000056111.4131From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000561.Hermaphrodite.WBbt:0007833.SRP029448.SRX343201
WBls:000058142.9922From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000581.Hermaphrodite.WBbt:0007833.SRP029448.SRX343202
WBls:000062119.9649From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000621.Hermaphrodite.WBbt:0007833.SRP029448.SRX343203
WBls:000067434.5367From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265366
37.1655From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265371
39.7597From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265369
41.2421From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265370
50.2496From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265368
52.9564From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000674.Hermaphrodite.WBbt:0007833.SRP021083.SRX265367
WBls:000067648.3671From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265375
49.8871From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265374
51.9766From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265373
64.9286From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000676.Hermaphrodite.WBbt:0007833.SRP021083.SRX265372
WBls:000069420.2434From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000694.Hermaphrodite.WBbt:0007833.SRP029448.SRX343205
WBls:00006956.89332From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000695.Hermaphrodite.WBbt:0007833.SRP029448.SRX343206
WBls:00006963.32066From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000696.Hermaphrodite.WBbt:0007833.SRP029448.SRX343207
WBls:00006978.36365From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000697.Hermaphrodite.WBbt:0007833.SRP029448.SRX343208
WBls:00006991.46704From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000699.Hermaphrodite.WBbt:0007833.SRP029448.SRX343210
WBls:000070015.3678From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000700.Hermaphrodite.WBbt:0007833.SRP029448.SRX343211
WBls:000070110.0287From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000701.Hermaphrodite.WBbt:0007833.SRP029448.SRX343212
WBls:00007029.53891From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000702.Hermaphrodite.WBbt:0007833.SRP029448.SRX343213
WBls:000070314.6311From_analysisRNASeq.elegans.WBStrain00000001.WBls:0000703.Hermaphrodite.WBbt:0007833.SRP029448.SRX343214
GO_annotation (76)
Ortholog (43)
Structured_descriptionConcise_descriptionhlh-2 encodes a Class I basic helix-loop-helix (bHLH) transcription factor that is the C. elegans ortholog of the mammalian E and Drosophila Daughterless transcriptional activators; HLH-2 activity is required for cell fate specifications occuring during embryonic and larval development that affect such processes as gonadogenesis, male tail formation, and programmed cell death; HLH-2 has been shown to dimerize with at least two C. elegans Acheate-scute homologs, LIN-32, a neural-specific protein with which it functions in male tail development and HLH-3, with which it is coexpressed in the nuclei of embryonic neuronal prescursors and with which it regulates the transcription of the EGL-1 cell death activator in the NSM sister cells; in gonadogenesis, HLH-2 is required for bestowing proAC competence on the cells that undergo the AC/VU (anchor cell/ventral uterine precursor) cell fate decision, for specification, differentiation, and function of the distal tip cell (DTC) and AC, including transcriptional regulation of the LAG-2 Delta-like ligand in the latter, and for formation of the uterine seam cell (utse); genetic analysis also suggests that HLH-2 functions with HLH-14, an additional Acaete-scute homolog, to specify the PVQ/HSN/PHB neuroblast cell lineage; HLH-2 is expressed in all nuclei of early embryos until the ~200-cell stage, when expression becomes increasingly restricted to neuronal cells and their immediate precursors; later expression is detected in, but not limited to, pharyngeal cells, anterior neurons, vulval and uterine muscles, the DTCs, the presumptive and mature AC, the Q neuroblast, and enteric muscles; comparative analysis of transcriptional and translational reporters indicates that hlh-2 is expressed in both the anchor cell and the ventral uterine (VU) precursor, but that expression in the latter is subject to post-transcriptional down-regulation; HLH-2 accumulation in the presumptive AC is the first detectable difference between the AC and VU precursors during the lateral specification event that distinguishes these two cell fates.Paper_evidenceWBPaper00002826
WBPaper00004492
WBPaper00006120
WBPaper00006303
WBPaper00006354
WBPaper00024330
Curator_confirmedWBPerson1843
Date_last_updated26 Aug 2004 00:00:00
Automated_descriptionEnables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; bHLH transcription factor binding activity; and protein dimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including generation of neurons; regulation of metabolic process; and sex differentiation. Located in cytoplasm and nucleus. Part of RNA polymerase II transcription regulator complex. Expressed in several structures, including distal tip cell; enteric muscle; lateral ganglion; ray precursor cell; and terminal bulb. Used to study obesity. Human ortholog(s) of this gene implicated in several diseases, including Fuchs' endothelial dystrophy; Pitt-Hopkins syndrome; and agammaglobulinemia (multiple). Is an ortholog of human TCF12 (transcription factor 12); TCF3 (transcription factor 3); and TCF4 (transcription factor 4).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:9970Homo sapiensPaper_evidenceWBPaper00061889
Curator_confirmedWBPerson324
Date_last_updated28 Jun 2022 00:00:00
Potential_modelDOID:3883Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11634)
DOID:9256Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11633)
DOID:2340Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11623)
DOID:0090070Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11623)
DOID:0060488Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11634)
DOID:10283Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11633)
DOID:11555Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11634)
DOID:0081140Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11633)
DOID:0081143Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:11633)
Models_disease_in_annotationWBDOannot00001265
Molecular_infoCorresponding_CDSM05B5.5a
Corresponding_transcript (2)
Corresponding_pseudogene_historyM05B5.5b:wp122
Other_sequence (12)
Associated_feature (17)
Gene_product_binds (22)
Transcription_factorWBTranscriptionFactor000080
WBTranscriptionFactor000063
WBTranscriptionFactor000078
WBTranscriptionFactor000076
WBTranscriptionFactor000082
WBTranscriptionFactor000083
WBTranscriptionFactor000079
WBTranscriptionFactor000084
WBTranscriptionFactor000077
WBTranscriptionFactor000081
Experimental_infoRNAi_result (80)
Expr_pattern (20)
Drives_construct (20)
Construct_product (15)
Regulate_expr_clusterWBPaper00059477:hlh-2(RNAi)_regulated
AntibodyWBAntibody00000147
WBAntibody00001214
WBAntibody00001643
Microarray_results (21)
Expression_cluster (200)
Interaction (108)
Map_infoMapIPosition1.83482Error0.002317
Well_ordered
PositivePositive_cloneC01H6
F21E8
M05B5Inferred_automaticallyFrom sequence, transcript, pseudogene data
Mapping_dataMulti_point3837
3838
3839
3840
3841
3842
4521
4760
Reference (133)
MethodGene