arf-1.2 encodes an ADP-ribosylation factor homolog required in vivo for embryonic development, fertility, locomotion, vulval development, and cuticular synthesis; ARF proteins are N-myristoylated GTPases that regulate membrane traffic and the actin cytoskeleton, and that activate both phospholipase D1 (PLD1) and phosphatidylinositol 4-phosphate 5-kinase.
Predicted to enable GTP binding activity and GTPase activity. Involved in several processes, including oocyte development; regulation of apoptotic process involved in development; and regulation of receptor-mediated endocytosis. Located in endoplasmic reticulum. Expressed in pharyngeal muscle cell; uterus; ventral nerve cord; and vulval precursor cell. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Is an ortholog of human ARF1 (ADP ribosylation factor 1) and ARF3 (ADP ribosylation factor 3).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.
CGC_data_submission
This gene was previously assigned the CGC name arf-1. It has been re-assigned to arf-1.2