WormBase Tree Display for Gene: WBGene00017123
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| WBGene00017123 | SMap | S_parent | Sequence | E04F6 | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | maoc-1 | Person_evidence | WBPerson1157 | |||||
| Sequence_name | E04F6.3 | ||||||||
| Molecular_name | E04F6.3 | ||||||||
| E04F6.3.1 | |||||||||
| CE01215 | |||||||||
| Other_name | CELE_E04F6.3 | Accession_evidence | NDB | BX284602 | |||||
| Public_name | maoc-1 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 28 May 2004 13:30:58 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
| 2 | 31 Aug 2005 14:07:05 | WBPerson2970 | Name_change | CGC_name | maoc-1 | ||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | maoc | ||||||||
| Allele (21) | |||||||||
| Strain | WBStrain00032684 | ||||||||
| WBStrain00040194 | |||||||||
| WBStrain00040195 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (13) | |||||||||
| Ortholog (40) | |||||||||
| Structured_description | Concise_description | maoc-1 encodes an ortholog of human HSD17B4 (OMIM:601860, mutated in D-bifunctional protein deficiency); MAOC-1 contains a MaoC-like domain found in diverse enzymes (HSD17B4, peroxisomal hydratase-dehydrogenase-epimerase, and the fatty acid synthase beta subunit) and by homology, is predicted to function in peroxisomal fatty acid beta-oxidation; loss of maoc-1 activity via RNAi results in lifespan extension, increased fat content, and an increased susceptibility to pathogens. | Paper_evidence | WBPaper00005655 | |||||
| WBPaper00013529 | |||||||||
| WBPaper00026715 | |||||||||
| WBPaper00028482 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| WBPerson567 | |||||||||
| Date_last_updated | 16 Dec 2007 00:00:00 | ||||||||
| Automated_description | Enables identical protein binding activity. Involved in defense response to Gram-negative bacterium and innate immune response. Predicted to be located in peroxisomal membrane. Used to study obesity. Human ortholog(s) of this gene implicated in D-bifunctional protein deficiency; Perrault syndrome; and Stiff-Person syndrome. Is an ortholog of human HSD17B4 (hydroxysteroid 17-beta dehydrogenase 4). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Experimental_model | DOID:9970 | Homo sapiens | Paper_evidence | WBPaper00035972 | ||||
| Curator_confirmed | WBPerson38202 | ||||||||
| Date_last_updated | 29 Jun 2018 00:00:00 | ||||||||
| Potential_model (3) | |||||||||
| Models_disease_asserted | WBDOannot00000569 | ||||||||
| Molecular_info | Corresponding_CDS | E04F6.3 | |||||||
| Corresponding_transcript | E04F6.3.1 | ||||||||
| Other_sequence | EX006989.1 | ||||||||
| Acan_isotig10756 | |||||||||
| FG619760.1 | |||||||||
| EX008982.1 | |||||||||
| FK809128.1 | |||||||||
| EX566264.1 | |||||||||
| HG11687 | |||||||||
| EX014924.1 | |||||||||
| PPC04898_1 | |||||||||
| EG025491.1 | |||||||||
| PPC05274_1 | |||||||||
| EX912399.1 | |||||||||
| ES744495.1 | |||||||||
| Hbac_isotig02356 | |||||||||
| ES743508.1 | |||||||||
| EX008313.1 | |||||||||
| HC09716 | |||||||||
| ES412591.1 | |||||||||
| EX011407.1 | |||||||||
| Tcir_isotig03219 | |||||||||
| EX912964.1 | |||||||||
| ES742298.1 | |||||||||
| EX911139.1 | |||||||||
| FD514985.1 | |||||||||
| EX557803.1 | |||||||||
| Name_isotig02945 | |||||||||
| EG025490.1 | |||||||||
| EX010418.1 | |||||||||
| EG025545.1 | |||||||||
| HCC12479_1 | |||||||||
| EX009626.1 | |||||||||
| PPC02385_1 | |||||||||
| AYC03850_1 | |||||||||
| EX010876.1 | |||||||||
| EX910330.1 | |||||||||
| EX012884.1 | |||||||||
| HBC16435_1 | |||||||||
| EG025801.1 | |||||||||
| ES743599.1 | |||||||||
| Tcir_isotig03220 | |||||||||
| EX913511.1 | |||||||||
| PP00778 | |||||||||
| CSC01660_1 | |||||||||
| ES409188.1 | |||||||||
| ES410840.1 | |||||||||
| FG619779.1 | |||||||||
| Tcol_isotig14942 | |||||||||
| EX015001.1 | |||||||||
| ES741458.1 | |||||||||
| EX013930.1 | |||||||||
| EX010278.1 | |||||||||
| ES740980.1 | |||||||||
| MIC08102_1 | |||||||||
| ES411837.1 | |||||||||
| HBC00225_1 | |||||||||
| ACC02301_1 | |||||||||
| EX913713.1 | |||||||||
| ES742423.1 | |||||||||
| CR05028 | |||||||||
| EX014155.1 | |||||||||
| EX909970.1 | |||||||||
| AE04662 | |||||||||
| EX007773.1 | |||||||||
| EX013959.1 | |||||||||
| ACC15576_1 | |||||||||
| EX015284.1 | |||||||||
| BXC01731_1 | |||||||||
| EX914775.1 | |||||||||
| Oden_isotig20736 | |||||||||
| JO469556.1 | |||||||||
| EX012762.1 | |||||||||
| CRC10657_1 | |||||||||
| JI174652.1 | |||||||||
| Associated_feature | WBsf644358 | ||||||||
| WBsf221572 | |||||||||
| Experimental_info | RNAi_result | WBRNAi00065091 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00063963 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00012692 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00108443 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00080807 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00023398 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00030502 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00043682 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00063964 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern | Expr12049 | ||||||||
| Expr13909 | |||||||||
| Expr1016601 | |||||||||
| Expr1037356 | |||||||||
| Expr1147666 | |||||||||
| Expr2013373 | |||||||||
| Expr2031605 | |||||||||
| Drives_construct | WBCnstr00020137 | ||||||||
| WBCnstr00027554 | |||||||||
| WBCnstr00040240 | |||||||||
| Construct_product | WBCnstr00020137 | ||||||||
| WBCnstr00023003 | |||||||||
| WBCnstr00027554 | |||||||||
| Microarray_results (20) | |||||||||
| Expression_cluster (200) | |||||||||
| Interaction (23) | |||||||||
| Map_info | Map | II | Position | 0.498761 | Error | 7.7e-05 | |||
| Positive | Positive_clone | E04F6 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
| Pseudo_map_position | |||||||||
| Reference (19) | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
