WormBase Tree Display for Gene: WBGene00009127

WBGene00009127 SMap: S_parent: Sequence: F25H5
  Identity: Version: 2
    Name: CGC_name: clsp-1 Person_evidence: WBPerson4143
      Sequence_name: F25H5.5
      Molecular_name: F25H5.5a
        F25H5.5a.1
        CE42710
        F25H5.5b
        CE46262
        F25H5.5b.1
      Other_name: CELE_F25H5.5 Accession_evidence: NDB BX284601
      Public_name: clsp-1
    DB_info: Database: AceView gene 1J736
        WormQTL gene WBGene00009127
        WormFlux gene WBGene00009127
        NDB locus_tag CELE_F25H5.5
        Panther gene CAEEL|WormBase=WBGene00009127|UniProtKB=O17838
          family PTHR14396
        NCBI gene 172742
        RefSeq protein NM_001377615.2
            NM_001264079.3
        TREEFAM TREEFAM_ID TF321962
        TrEMBL UniProtAcc G3MU54
            O17838
        UniProt_GCRP UniProtAcc O17838
    Species: Caenorhabditis elegans
    History: Version_change (2)
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: clsp
    Allele (50)
    RNASeq_FPKM (74)
    GO_annotation: 00009076
      00009077
      00009078
      00009079
      00009080
      00009081
    Contained_in_operon: CEOP1540
    Ortholog (27)
    Structured_description: Concise_description: F25H5.5 encodes the C. elegans homologue of Claspin, an S-phase checkpoint component that interacts with Chk1 and negatively regulates cell cycle progression; in wild-type animals, loss of F25H5.5 activity results in some embryonic lethality; loss of F25H5.5 activity in a lin-35 mutant background, however, results in sterility, as well as smaller than normal body size, uncoordinated locomotion, and a protruding vulva; weaker F25H5.5 RNAi phenotypes are seen in lin-15B and eri-1; lin-15B backgrounds. Paper_evidence: WBPaper00004651
            WBPaper00029258
          Curator_confirmed: WBPerson1843
          Date_last_updated: 14 Feb 2008 00:00:00
      Automated_description: Predicted to enable anaphase-promoting complex binding activity. Predicted to be involved in mitotic DNA replication checkpoint signaling and mitotic G2 DNA damage checkpoint signaling. Located in nucleus. Is an ortholog of human CLSPN (claspin). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Molecular_info: Corresponding_CDS: F25H5.5a
      F25H5.5b
    Corresponding_CDS_history: F25H5.5:wp192
    Corresponding_transcript: F25H5.5a.1
      F25H5.5b.1
    Other_sequence: Tcir_isotig02602
      Oden_isotig06034
      Tcol_isotig02024
      JI166980.1
      Name_isotig07247
      Hbac_isotig00947
      CBC05391_1
      Dviv_isotig10888
      Oden_isotig06033
      GO240257.1
      AE01477
      GE638859.1
      Hbac_isotig00946
      JI479057.1
      CBC14671_1
      Dviv_isotig10887
      Oden_isotig06032
      GE638553.1
      EX537626.1
      FG352921.1
      CBC17543_1
      Tcir_isotig02603
      EX552906.1
      Tcol_isotig02025
      ACC05423_1
      EX545453.1
      CJC14018_1
      PPC16233_1
      GE638762.1
      Acan_isotig08773
      GE639433.1
      GE638131.1
      AYC00237_1
    Associated_feature: WBsf649452
      WBsf220047
      WBsf220048
      WBsf220049
  Experimental_info: RNAi_result (19)
    Expr_pattern: Expr8725
      Expr1026132
      Expr1033977
      Expr1149465
      Expr2010255
      Expr2028497
    Drives_construct: WBCnstr00032443
    Construct_product: WBCnstr00007587
      WBCnstr00013483
      WBCnstr00032443
    Antibody: WBAntibody00002990
    Microarray_results (20)
    Expression_cluster (120)
    Interaction (39)
  Map_info: Map: I Position: 3.63002
    Positive: Positive_clone: F25H5 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00029258
    WBPaper00033469
    WBPaper00038491
    WBPaper00049963
    WBPaper00055090
    WBPaper00062444
    WBPaper00066002
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene