WormBase Tree Display for Gene: WBGene00004919
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| WBGene00004919 | Evidence | Paper_evidence | WBPaper00005457 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| SMap | S_parent | Sequence | Y49E10 | ||||||
| Identity | Version | 1 | |||||||
| Name | CGC_name | snr-6 | Person_evidence | WBPerson167 | |||||
| Sequence_name | Y49E10.15 | ||||||||
| Molecular_name | Y49E10.15 | ||||||||
| Y49E10.15.1 | |||||||||
| CE22230 | |||||||||
| Other_name | CELE_Y49E10.15 | Accession_evidence | NDB | BX284603 | |||||
| Public_name | snr-6 | ||||||||
| DB_info | Database (11) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:36 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | snr | ||||||||
| Allele (16) | |||||||||
| Strain | WBStrain00051373 | ||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (22) | |||||||||
| Ortholog (34) | |||||||||
| Structured_description | Concise_description | snr-6 encodes the C. elegans ortholog of the small nuclear ribonucleoprotein E, one of seven subunits of the heptameric Sm complex required for the biogenesis and function of snRNPs that catalyze mRNA splicing; in addition to its predicted role in pre-mRNA processing, SNR-6 activity is essential for embryogenesis and is required for several aspects of germ cell specification including cell division patterns, localization and subcellular distribution of P granules, maintenance of transcriptional quiescence, and expression of the germ lineage-specific proteins PIE-1, GLD-1, and NOS-2; snr-6 is also required for wild-type levels of fertility; immunostaining of adults and embryos using antibodies raised against mammalian Sm proteins suggests that SNR-6 localizes to the nucleus and cytoplasm in many cell types, as well as to P granules in germ cells and their embryonic precursors. | Paper_evidence | WBPaper00004403 | |||||
| WBPaper00005457 | |||||||||
| WBPaper00006395 | |||||||||
| WBPaper00025054 | |||||||||
| WBPaper00027038 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 25 Jul 2006 00:00:00 | ||||||||
| Automated_description | Predicted to enable RNA binding activity. Predicted to be involved in spliceosomal snRNP assembly. Located in P granule. Expressed in gonad. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); hypotrichosis (multiple); and lupus nephritis. Is an ortholog of human SNRPE (small nuclear ribonucleoprotein polypeptide E). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0110698 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11161) | ||||
| DOID:0110708 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11161) | ||||||
| DOID:769 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11161) | ||||||
| DOID:0080162 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11161) | ||||||
| DOID:9261 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11161) | ||||||
| DOID:9952 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11161) | ||||||
| DOID:3910 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11161) | ||||||
| DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11161) | ||||||
| DOID:684 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:11161) | ||||||
| Molecular_info | Corresponding_CDS | Y49E10.15 | |||||||
| Corresponding_transcript | Y49E10.15.1 | ||||||||
| Other_sequence | CBC12150_1 | ||||||||
| HG02922 | |||||||||
| FC818767.1 | |||||||||
| HG12338 | |||||||||
| SR01156 | |||||||||
| MHC02809_1 | |||||||||
| SSC03383_1 | |||||||||
| FG353117.1 | |||||||||
| Tcir_isotig06255 | |||||||||
| GR12160 | |||||||||
| HCC00683_1 | |||||||||
| GR17712 | |||||||||
| HC02948 | |||||||||
| SS03385 | |||||||||
| ES412139.1 | |||||||||
| BU086845.1 | |||||||||
| MC00060 | |||||||||
| Acan_isotig05394 | |||||||||
| AI218768.1 | |||||||||
| Tcir_isotig16077 | |||||||||
| JI175266.1 | |||||||||
| GRC00556_1 | |||||||||
| CJC00545_1 | |||||||||
| NAC01470_1 | |||||||||
| GR11733 | |||||||||
| RSC04403_1 | |||||||||
| HBC05449_1 | |||||||||
| HGC02274_1 | |||||||||
| Tcol_isotig21484 | |||||||||
| GPC00159_1 | |||||||||
| TS03603 | |||||||||
| PP01224 | |||||||||
| OOC03285_1 | |||||||||
| EX014387.1 | |||||||||
| MCC05221_1 | |||||||||
| ES741710.1 | |||||||||
| TSC02181_1 | |||||||||
| MI08820 | |||||||||
| OVC02485_1 | |||||||||
| Hbac_isotig06139 | |||||||||
| MPC01722_1 | |||||||||
| ASC21586_1 | |||||||||
| MH06771 | |||||||||
| FG352164.1 | |||||||||
| Tcir_isotig05527 | |||||||||
| Acan_isotig05826 | |||||||||
| SRC03263_1 | |||||||||
| GRC00935_1 | |||||||||
| Name_isotig09301 | |||||||||
| Dviv_isotig19087 | |||||||||
| EX013657.1 | |||||||||
| Tcir_isotig05528 | |||||||||
| EX010780.1 | |||||||||
| EX916274.1 | |||||||||
| Tcol_isotig23538 | |||||||||
| RS07145 | |||||||||
| MIC06729_1 | |||||||||
| MH02575 | |||||||||
| GR19396 | |||||||||
| FG350248.1 | |||||||||
| GR18010 | |||||||||
| FG581541.1 | |||||||||
| NB07143 | |||||||||
| Oden_isotig26640 | |||||||||
| MC00971 | |||||||||
| NBC01418_1 | |||||||||
| GR977746.1 | |||||||||
| MH10386 | |||||||||
| FG581738.1 | |||||||||
| Acan_isotig05395 | |||||||||
| EX910991.1 | |||||||||
| GR17713 | |||||||||
| ACC03874_1 | |||||||||
| AS16841 | |||||||||
| HC09402 | |||||||||
| GP00584 | |||||||||
| SC00322 | |||||||||
| PPC00199_1 | |||||||||
| CN478252.1 | |||||||||
| Dviv_isotig19088 | |||||||||
| ES743305.1 | |||||||||
| Acan_isotig20603 | |||||||||
| Associated_feature | WBsf667524 | ||||||||
| WBsf667525 | |||||||||
| WBsf227665 | |||||||||
| Experimental_info (6) | |||||||||
| Map_info | Map | III | Position | 17.7919 | Error | 0.019258 | |||
| Positive | Positive_clone | Y49E10 | Inferred_automatically | From CDS info | |||||
| From sequence, transcript, pseudogene data | |||||||||
| Pseudo_map_position | |||||||||
| Reference | WBPaper00005457 | ||||||||
| WBPaper00027038 | |||||||||
| WBPaper00038491 | |||||||||
| WBPaper00040897 | |||||||||
| WBPaper00045396 | |||||||||
| WBPaper00046572 | |||||||||
| WBPaper00049828 | |||||||||
| WBPaper00055090 | |||||||||
| Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
| Method | Gene |
