WormBase Tree Display for Gene: WBGene00003995
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WBGene00003995 | SMap | S_parent | Sequence | K08E7 | |||
---|---|---|---|---|---|---|---|
Identity (6) | |||||||
Gene_info | Biotype | SO:0001217 | |||||
Gene_class | pgp | ||||||
Allele (118) | |||||||
Legacy_information | [C.elegansII] pk17 : deletion derived from pk28tci, no apparent drug sensitivity or other phenotype. Cloned: encodes 1321 aa P-glycoprotein, 61-65% identical to mammalian P-glycoproteins.Transcripts relatively low, peak early;pgp-1:lacZ expressed in intestine, throughout development. Tagged PGP-1 detected in gut apical membrane. [Broeks et al. 1995; NL] | ||||||
Strain | WBStrain00028887 | ||||||
WBStrain00028889 | |||||||
WBStrain00028891 | |||||||
RNASeq_FPKM (74) | |||||||
GO_annotation (22) | |||||||
Ortholog (64) | |||||||
Paralog (23) | |||||||
Structured_description | Concise_description | pgp-1 encodes a transmembrane protein that is a member of the P-glycoprotein subclass of the ATP-binding cassette (ABC) transporter superfamily; along with PGP-3, PGP-1 is required for defense against the pathogenic Pseudomonas aeruginosa strain PA14, and may facilitate ATP-dependent efflux of the toxic phenazine compounds produced by the bacteria; PGP-1 is expressed in the apical membrane of intestinal cells and in the intestinal valve cells. | Paper_evidence | WBPaper00002180 | |||
WBPaper00003366 | |||||||
WBPaper00003925 | |||||||
WBPaper00005654 | |||||||
Curator_confirmed | WBPerson1843 | ||||||
Date_last_updated | 17 Jun 2004 00:00:00 | ||||||
Automated_description | Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in defense response to other organism; response to metal ion; and response to nematicide. Located in apical plasma membrane. Expressed in intestinal cell; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); and intrahepatic cholestasis (multiple). Is an ortholog of human ABCB1 (ATP binding cassette subfamily B member 1); ABCB4 (ATP binding cassette subfamily B member 4); and ABCB5 (ATP binding cassette subfamily B member 5). | Paper_evidence | WBPaper00065943 | ||||
Curator_confirmed | WBPerson324 | ||||||
WBPerson37462 | |||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||
Disease_info | Potential_model (41) | ||||||
Molecular_info | Corresponding_CDS | K08E7.9 | |||||
Corresponding_transcript | K08E7.9.1 | ||||||
Other_sequence | PPC09469_1 | ||||||
CRC04277_1 | |||||||
HCC00171_1 | |||||||
FC539314.1 | |||||||
Dviv_isotig30235 | |||||||
HCC00125_1 | |||||||
Dviv_isotig28776 | |||||||
Dviv_isotig16815 | |||||||
CR09910 | |||||||
HCC00169_1 | |||||||
FE915550.1 | |||||||
FR691853.1 | |||||||
DN190382.1 | |||||||
HC05915 | |||||||
Acan_isotig14364 | |||||||
DN191349.1 | |||||||
HC05911 | |||||||
HC00679 | |||||||
CR10044 | |||||||
Tcol_isotig21455 | |||||||
Dviv_isotig16814 | |||||||
Hbac_isotig07624 | |||||||
FG972040.1 | |||||||
CRC11175_1 | |||||||
Associated_feature | WBsf652305 | ||||||
WBsf998168 | |||||||
WBsf998169 | |||||||
WBsf1018397 | |||||||
WBsf231042 | |||||||
WBsf231043 | |||||||
Experimental_info | RNAi_result | WBRNAi00070104 | Inferred_automatically | RNAi_primary | |||
WBRNAi00016820 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00085165 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00050311 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00085169 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00091137 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00085175 | Inferred_automatically | RNAi_primary | |||||
Expr_pattern | Expr710 | ||||||
Expr1546 | |||||||
Expr1548 | |||||||
Expr3339 | |||||||
Expr12394 | |||||||
Expr1021232 | |||||||
Expr1031911 | |||||||
Expr1154012 | |||||||
Expr2014868 | |||||||
Expr2033103 | |||||||
Drives_construct | WBCnstr00010330 | ||||||
WBCnstr00011335 | |||||||
WBCnstr00012502 | |||||||
WBCnstr00017594 | |||||||
WBCnstr00017595 | |||||||
WBCnstr00019886 | |||||||
WBCnstr00035755 | |||||||
Construct_product | WBCnstr00007868 | ||||||
WBCnstr00007870 | |||||||
WBCnstr00007871 | |||||||
WBCnstr00019886 | |||||||
WBCnstr00035755 | |||||||
Antibody | WBAntibody00000095 | ||||||
Microarray_results (18) | |||||||
Expression_cluster (314) | |||||||
Interaction (63) | |||||||
WBProcess | WBbiopr:00000096 | ||||||
Map_info | Map | IV | Position | 6.0845 | Error | 0.005937 | |
Positive | Positive_clone | K08E7 | Inferred_automatically | From sequence, transcript, pseudogene data | |||
PB#CPG10 | |||||||
Pseudo_map_position | |||||||
Reference (45) | |||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||
Method | Gene |