WormBase Tree Display for Gene: WBGene00003214

WBGene00003214 SMap: S_parent: Sequence: C05D11
  Identity: Version: 1
    Name: CGC_name: mel-32 Person_evidence: WBPerson314
      Sequence_name: C05D11.11
      Molecular_name: C05D11.11a
        C05D11.11a.1
        CE01130
        C05D11.11b
        CE29661
        C05D11.11a.2
        C05D11.11a.3
        C05D11.11b.1
      Other_name: CELE_C05D11.11 Accession_evidence: NDB BX284603
      Public_name: mel-32
    DB_info: Database (12)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:31 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: mel
    Allele (60)
    Legacy_information: [Vatcher GP] homozygotes develope into adults that lay egg which do not hatch.
      [Schnabel H] other name: emb-25 NA18
    Complementation_data: [Vatcher GP] complements let-713 (s2449), let-721(s2447), let-725(s2454), let-728(2573), let-747(s2456), let-756(s2613), let-767(s2464).
    Strain: WBStrain00001425
      WBStrain00000962
    RNASeq_FPKM (74)
    GO_annotation (34)
    Ortholog (42)
    Structured_description: Concise_description: mel-32 encodes a serine hydroxymethyltransferase; by homology, MEL-32 is predicted to catalyze the biochemical reaction that converts serine to glycine and in the process transfers a methyl group to tetrahydrofolate and, thus, into the one-carbon pool used for a variety of cellular metabolic processes; in C. elegans MEL-32 activity is required maternally for embryonic development past the 100-cell stage. Paper_evidence (2)
          Curator_confirmed: WBPerson1843
          Date_last_updated: 10 Jan 2008 00:00:00
      Automated_description: Predicted to enable several functions, including glycine hydroxymethyltransferase activity; ion binding activity; and nucleic acid binding activity. Involved in embryo development. Located in mitochondrion. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Is an ortholog of human SHMT1 (serine hydroxymethyltransferase 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2394 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10850)
      DOID:1612 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10850)
  Molecular_info: Corresponding_CDS: C05D11.11a
      C05D11.11b
    Corresponding_transcript: C05D11.11a.1
      C05D11.11a.2
      C05D11.11a.3
      C05D11.11b.1
    Other_sequence: HG09902
      CR11479
      Hbac_isotig00584
      Dviv_isotig08534
      FK805151.1
      Tcol_isotig18364
      Tcir_isotig01482
      Tcol_isotig01967
      FK808133.1
      Oden_contig03586
      ES564306.1
      EX502879.1
      ES568512.1
      FE914996.1
      MP00416
      BXC03673_1
      FK799837.1
      FC549790.1
      CB038778.1
      EY461329.1
      EX555648.1
      EX011650.1
      JO472790.1
      Acan_isotig21907
      Tcir_isotig01480
      EX009375.1
      FK803492.1
      GPC00577_1
      ES742815.1
      ES564664.1
      XI02772
      JI474334.1
      JI473325.1
      PVC04351_1
      EX565791.1
      EY470572.1
      Tcol_isotig01964
      CJC02253_1
      XI00239
      JI166937.1
      EX538459.1
      Tcol_isotig01965
      FF678392.1
      AYC02946_1
      EY471661.1
      HGC08050_1
      EW742603.1
      Tcol_isotig01968
      FC818144.1
      EY463525.1
      CRC02558_1
      TX01218
      ASC28832_1
      CJC00156_1
      ACC26408_1
      FC818161.1
      CBC05344_1
      ES568472.1
      EX539902.1
      GP01125
      FC812488.1
      EX499790.1
      FC543770.1
      Dviv_isotig08533
      EY458402.1
      ACC22308_1
      FE914857.1
      FK805466.1
      EX543296.1
      FC812506.1
      ASC38444_1
      FG971422.1
      EX536662.1
      FK807405.1
      EX500156.1
      EY470411.1
      Tcir_isotig18825
      EX913907.1
      Dviv_isotig08535
      Name_isotig01419
      SR02406
      JI463659.1
      TS00846
      JI477824.1
      GR16671
      GP01135
      FK807611.1
      FK802528.1
      EX553720.1
      EY458256.1
      SRC04307_1
      JI170371.1
      AE00364
      FC540605.1
      Tcol_isotig01966
      Tcol_isotig01963
      ES564064.1
      EX912395.1
      ACC05959_1
      FG981020.1
      Tcir_isotig01481
      EX537734.1
      Dviv_isotig08532
      Tcir_isotig15225
      ACC20000_1
      Acan_isotig06012
      HC05581
      EY472576.1
      PTC01452_1
      TSC00143_1
      EX540114.1
      FF678714.1
      HC05397
      AYC02624_1
      FG977801.1
      EX540575.1
      EW741439.1
      EL888426.1
      MPC00510_1
      HBC03427_1
      HCC06947_1
      JO472505.1
      EY467248.1
      TDC00709_1
      BXC03927_1
      ACC37351_1
      Tcol_isotig01962
      EX547236.1
      Tcol_isotig01960
      HBC14196_1
      ES569473.1
      Dviv_isotig08536
      TS03490
      Acan_isotig06013
      AE02345
      XIC00232_1
      CR02332
      ES739482.1
      Tcol_isotig01961
      FC539704.1
    Associated_feature: WBsf651128
      WBsf666995
      WBsf666996
      WBsf992765
      WBsf992766
      WBsf226823
      WBsf226824
      WBsf226825
  Experimental_info: RNAi_result (11)
    Expr_pattern: Chronogram490
      Expr5167
      Expr1024771
      Expr1031517
      Expr1143823
      Expr2013519
      Expr2031753
    Drives_construct: WBCnstr00002309
      WBCnstr00036183
    Construct_product: WBCnstr00036183
    Microarray_results (30)
    Expression_cluster (200)
    Interaction (121)
  Map_info: Map: III Position: -1.27054 Error: 0.001406
    Well_ordered
    Positive: Inside_rearr: sDf127
        sDf125
        sDp3
      Positive_clone: C05D11 Inferred_automatically: From sequence, transcript, pseudogene data
        pC05.11
    Negative: Outside_rearr: sDf121
    Mapping_data: Pos_neg_data: 9286
        9287
        9288
        9289
  Reference (25)
  Remark: pC05.11 is a subclone of C05D11 containing only ORF 11. It partially rescues the Mel phenotype.
    Sequence connections updated by Darin Blasiar Jan, 2002
  Method: Gene