WormBase Tree Display for Gene: WBGene00003153
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| WBGene00003153 | SMap | S_parent | Sequence | Y67D8C | |||||
|---|---|---|---|---|---|---|---|---|---|
| Identity | Version | 2 | |||||||
| Name | CGC_name | mca-3 | |||||||
| Sequence_name | Y67D8C.10 | ||||||||
| Molecular_name (21) | |||||||||
| Other_name | cup-7 | Person_evidence | WBPerson170 | ||||||
| CELE_Y67D8C.10 | Accession_evidence | NDB | BX284604 | ||||||
| Public_name | mca-3 | ||||||||
| DB_info | Database (13) | ||||||||
| Species | Caenorhabditis elegans | ||||||||
| History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Acquires_merge | WBGene00000847 | ||
| Imported | Initial conversion from geneace | ||||||||
| 2 | 09 Oct 2007 09:36:44 | WBPerson2970 | Name_change | Other_name | cup-7 | ||||
| Acquires_merge | WBGene00000847 | ||||||||
| Status | Live | ||||||||
| Gene_info | Biotype | SO:0001217 | |||||||
| Gene_class | mca | ||||||||
| Allele (491) | |||||||||
| Legacy_information | [Kraev A] mca for Membrane Calcium ATPase. No mutants known. See mca-1. | ||||||||
| Strain | WBStrain00032351 | ||||||||
| WBStrain00008044 | |||||||||
| WBStrain00008045 | |||||||||
| WBStrain00007591 | |||||||||
| RNASeq_FPKM (74) | |||||||||
| GO_annotation (30) | |||||||||
| Ortholog (55) | |||||||||
| Paralog (14) | |||||||||
| Structured_description | Concise_description | mca-3 encodes one of three C. elegans plasma membrane Ca2+ ATPases (PMCAs); by homology, MCA-3 is predicted to function as a molecular pump that couples ATP hydrolysis to extrusion of cytosolic Ca2+; mca-3 activity is required for coelomoycte endocytosis, normal coordinated locomotion, and embryonic and larval development; in regulating endocytosis, MCA-3 is required specifically in the early stages for recruitment of the endocytic machinery to the plasma membrane; an mca-3::gfp reporter is expressed from embryogenesis through adulthood and seen in body wall muscle, the nervous system, intestine, and coelomocytes; in coelomocytes, an MCA-3::GFP fusion protein localizes to the plasma membrane. | Paper_evidence | WBPaper00003407 | |||||
| WBPaper00004883 | |||||||||
| WBPaper00029172 | |||||||||
| Curator_confirmed | WBPerson1843 | ||||||||
| Date_last_updated | 30 Apr 2007 00:00:00 | ||||||||
| Automated_description | Predicted to enable P-type calcium transporter activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; nematode larval development; and positive regulation of growth rate. Located in plasma membrane. Expressed in body wall musculature; coelomocyte; intestine; nervous system; and touch receptor neurons. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; and nonsyndromic deafness (multiple). Is an ortholog of several human genes including ATP2B1 (ATPase plasma membrane Ca2+ transporting 1); ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). | Paper_evidence | WBPaper00065943 | ||||||
| Curator_confirmed | WBPerson324 | ||||||||
| WBPerson37462 | |||||||||
| Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
| Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
| Disease_info | Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814) | ||||
| DOID:0111829 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:816) | ||||||
| DOID:0050564 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) | ||||||
| DOID:0110467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) | ||||||
| DOID:11714 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) | ||||||
| DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) | ||||||
| Molecular_info | Corresponding_CDS | Y67D8C.10a | |||||||
| Y67D8C.10b | |||||||||
| Y67D8C.10c | |||||||||
| Y67D8C.10d | |||||||||
| Y67D8C.10e | |||||||||
| Corresponding_transcript (11) | |||||||||
| Other_sequence | JI473155.1 | ||||||||
| HG08854 | |||||||||
| HBC14109_1 | |||||||||
| JI217849.1 | |||||||||
| FC818452.1 | |||||||||
| EX913385.1 | |||||||||
| Acan_isotig22866 | |||||||||
| MP01944 | |||||||||
| DA01827 | |||||||||
| JI164299.1 | |||||||||
| MH03971 | |||||||||
| Hbac_isotig00308 | |||||||||
| BMC08443_1 | |||||||||
| JI216233.1 | |||||||||
| CRC01896_1 | |||||||||
| EX911904.1 | |||||||||
| Acan_isotig13499 | |||||||||
| Tcol_isotig25351 | |||||||||
| JI171148.1 | |||||||||
| TX01577 | |||||||||
| HGC04117_1 | |||||||||
| JI469235.1 | |||||||||
| MH07094 | |||||||||
| GR12861 | |||||||||
| Oden_isotig18568 | |||||||||
| MH08164 | |||||||||
| WBC01001_1 | |||||||||
| BM00603 | |||||||||
| MA00042 | |||||||||
| FK801572.1 | |||||||||
| DAC00006_1 | |||||||||
| GT571174.1 | |||||||||
| FG619345.1 | |||||||||
| MHC10596_1 | |||||||||
| FC544342.1 | |||||||||
| MH08942 | |||||||||
| Hbac_isotig00309 | |||||||||
| ASC03148_1 | |||||||||
| GRC01921_1 | |||||||||
| Oden_isotig21785 | |||||||||
| CRC04369_1 | |||||||||
| DI01076 | |||||||||
| FE907666.1 | |||||||||
| SR01716 | |||||||||
| HG05110 | |||||||||
| GPC02525_1 | |||||||||
| CBC02831_1 | |||||||||
| FD515346.1 | |||||||||
| OF00086 | |||||||||
| FK804146.1 | |||||||||
| PSC02290_1 | |||||||||
| FF678473.1 | |||||||||
| Dviv_isotig33485 | |||||||||
| MHC06487_1 | |||||||||
| AS17732 | |||||||||
| JI173624.1 | |||||||||
| MJ00772 | |||||||||
| CRC04995_1 | |||||||||
| TM03525 | |||||||||
| JI483656.1 | |||||||||
| Dviv_isotig28437 | |||||||||
| MHC12309_1 | |||||||||
| JO468808.1 | |||||||||
| GP02339 | |||||||||
| MJ03615 | |||||||||
| GW410509.1 | |||||||||
| AS16467 | |||||||||
| ACC25580_1 | |||||||||
| EX911378.1 | |||||||||
| CD455739.1 | |||||||||
| OFC00015_1 | |||||||||
| FK806146.1 | |||||||||
| Dviv_isotig33250 | |||||||||
| SS00976 | |||||||||
| AS18029 | |||||||||
| CR05631 | |||||||||
| SS03313 | |||||||||
| HBC00464_1 | |||||||||
| AS09988 | |||||||||
| GP01842 | |||||||||
| SRC00540_1 | |||||||||
| GW411884.1 | |||||||||
| GP01108 | |||||||||
| CR06354 | |||||||||
| GPC01652_1 | |||||||||
| Acan_isotig08768 | |||||||||
| BM01518 | |||||||||
| Dviv_isotig07870 | |||||||||
| GW915714.1 | |||||||||
| CV200704.1 | |||||||||
| MAC00230_1 | |||||||||
| JO468478.1 | |||||||||
| FG977858.1 | |||||||||
| AE02829 | |||||||||
| SSC04094_1 | |||||||||
| BMC06835_1 | |||||||||
| SR01572 | |||||||||
| GT570804.1 | |||||||||
| CR00659 | |||||||||
| EX911134.1 | |||||||||
| JI474575.1 | |||||||||
| JI464414.1 | |||||||||
| SS02107 | |||||||||
| TMC05117_1 | |||||||||
| AE01992 | |||||||||
| DW718478.1 | |||||||||
| BE238932.1 | |||||||||
| Acan_isotig17614 | |||||||||
| BXC01975_1 | |||||||||
| FC545549.1 | |||||||||
| JI462209.1 | |||||||||
| GP03224 | |||||||||
| EL889437.1 | |||||||||
| FK804659.1 | |||||||||
| JI474832.1 | |||||||||
| AYC01140_1 | |||||||||
| Dviv_contig17507 | |||||||||
| FC815351.1 | |||||||||
| CD455450.1 | |||||||||
| SSC05731_1 | |||||||||
| Tcol_isotig17317 | |||||||||
| CSC02141_1 | |||||||||
| SRC03646_1 | |||||||||
| PT04740 | |||||||||
| DA01826 | |||||||||
| Associated_feature (33) | |||||||||
| Experimental_info | RNAi_result | WBRNAi00103077 | Inferred_automatically | RNAi_primary | |||||
| WBRNAi00009413 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00110940 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00057995 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00026914 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103078 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00103079 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00066558 | Inferred_automatically | RNAi_primary | |||||||
| WBRNAi00021260 | Inferred_automatically | RNAi_primary | |||||||
| Expr_pattern (8) | |||||||||
| Drives_construct | WBCnstr00008391 | ||||||||
| Construct_product | WBCnstr00000243 | ||||||||
| WBCnstr00000246 | |||||||||
| WBCnstr00000247 | |||||||||
| Microarray_results (52) | |||||||||
| Expression_cluster (158) | |||||||||
| Interaction (38) | |||||||||
| Map_info | Map | IV | Position | -5.83327 | Error | 0.101838 | |||
| Positive | Positive_clone | Y67D8 | |||||||
| Y67D8C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
| Mapping_data | Multi_point | 3954 | |||||||
| Reference (11) | |||||||||
| Method | Gene |
