WormBase Tree Display for Gene: WBGene00003153
expand all nodes | collapse all nodes | view schema
WBGene00003153 | SMap | S_parent | Sequence | Y67D8C | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | mca-3 | |||||||
Sequence_name | Y67D8C.10 | ||||||||
Molecular_name (21) | |||||||||
Other_name | cup-7 | Person_evidence | WBPerson170 | ||||||
CELE_Y67D8C.10 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | mca-3 | ||||||||
DB_info | Database (13) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Acquires_merge | WBGene00000847 | ||
Imported | Initial conversion from geneace | ||||||||
2 | 09 Oct 2007 09:36:44 | WBPerson2970 | Name_change | Other_name | cup-7 | ||||
Acquires_merge | WBGene00000847 | ||||||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | mca | ||||||||
Allele (491) | |||||||||
Legacy_information | [Kraev A] mca for Membrane Calcium ATPase. No mutants known. See mca-1. | ||||||||
Strain | WBStrain00032351 | ||||||||
WBStrain00008044 | |||||||||
WBStrain00008045 | |||||||||
WBStrain00007591 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (30) | |||||||||
Ortholog (55) | |||||||||
Paralog (14) | |||||||||
Structured_description | Concise_description | mca-3 encodes one of three C. elegans plasma membrane Ca2+ ATPases (PMCAs); by homology, MCA-3 is predicted to function as a molecular pump that couples ATP hydrolysis to extrusion of cytosolic Ca2+; mca-3 activity is required for coelomoycte endocytosis, normal coordinated locomotion, and embryonic and larval development; in regulating endocytosis, MCA-3 is required specifically in the early stages for recruitment of the endocytic machinery to the plasma membrane; an mca-3::gfp reporter is expressed from embryogenesis through adulthood and seen in body wall muscle, the nervous system, intestine, and coelomocytes; in coelomocytes, an MCA-3::GFP fusion protein localizes to the plasma membrane. | Paper_evidence | WBPaper00003407 | |||||
WBPaper00004883 | |||||||||
WBPaper00029172 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 30 Apr 2007 00:00:00 | ||||||||
Automated_description | Predicted to enable P-type calcium transporter activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; nematode larval development; and positive regulation of growth rate. Located in plasma membrane. Expressed in body wall musculature; coelomocyte; intestine; nervous system; and touch receptor neurons. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1; autosomal dominant intellectual developmental disorder; and nonsyndromic deafness (multiple). Is an ortholog of several human genes including ATP2B1 (ATPase plasma membrane Ca2+ transporting 1); ATP2B2 (ATPase plasma membrane Ca2+ transporting 2); and ATP2B3 (ATPase plasma membrane Ca2+ transporting 3). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0060307 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814) | ||||
DOID:0111829 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:816) | ||||||
DOID:0050564 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) | ||||||
DOID:0110467 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:815) | ||||||
DOID:11714 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) | ||||||
DOID:10591 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:814,HGNC:815,HGNC:816,HGNC:817) | ||||||
Molecular_info | Corresponding_CDS | Y67D8C.10a | |||||||
Y67D8C.10b | |||||||||
Y67D8C.10c | |||||||||
Y67D8C.10d | |||||||||
Y67D8C.10e | |||||||||
Corresponding_transcript (11) | |||||||||
Other_sequence | JI473155.1 | ||||||||
HG08854 | |||||||||
HBC14109_1 | |||||||||
JI217849.1 | |||||||||
FC818452.1 | |||||||||
EX913385.1 | |||||||||
Acan_isotig22866 | |||||||||
MP01944 | |||||||||
DA01827 | |||||||||
JI164299.1 | |||||||||
MH03971 | |||||||||
Hbac_isotig00308 | |||||||||
BMC08443_1 | |||||||||
JI216233.1 | |||||||||
CRC01896_1 | |||||||||
EX911904.1 | |||||||||
Acan_isotig13499 | |||||||||
Tcol_isotig25351 | |||||||||
JI171148.1 | |||||||||
TX01577 | |||||||||
HGC04117_1 | |||||||||
JI469235.1 | |||||||||
MH07094 | |||||||||
GR12861 | |||||||||
Oden_isotig18568 | |||||||||
MH08164 | |||||||||
WBC01001_1 | |||||||||
BM00603 | |||||||||
MA00042 | |||||||||
FK801572.1 | |||||||||
DAC00006_1 | |||||||||
GT571174.1 | |||||||||
FG619345.1 | |||||||||
MHC10596_1 | |||||||||
FC544342.1 | |||||||||
MH08942 | |||||||||
Hbac_isotig00309 | |||||||||
ASC03148_1 | |||||||||
GRC01921_1 | |||||||||
Oden_isotig21785 | |||||||||
CRC04369_1 | |||||||||
DI01076 | |||||||||
FE907666.1 | |||||||||
SR01716 | |||||||||
HG05110 | |||||||||
GPC02525_1 | |||||||||
CBC02831_1 | |||||||||
FD515346.1 | |||||||||
OF00086 | |||||||||
FK804146.1 | |||||||||
PSC02290_1 | |||||||||
FF678473.1 | |||||||||
Dviv_isotig33485 | |||||||||
MHC06487_1 | |||||||||
AS17732 | |||||||||
JI173624.1 | |||||||||
MJ00772 | |||||||||
CRC04995_1 | |||||||||
TM03525 | |||||||||
JI483656.1 | |||||||||
Dviv_isotig28437 | |||||||||
MHC12309_1 | |||||||||
JO468808.1 | |||||||||
GP02339 | |||||||||
MJ03615 | |||||||||
GW410509.1 | |||||||||
AS16467 | |||||||||
ACC25580_1 | |||||||||
EX911378.1 | |||||||||
CD455739.1 | |||||||||
OFC00015_1 | |||||||||
FK806146.1 | |||||||||
Dviv_isotig33250 | |||||||||
SS00976 | |||||||||
AS18029 | |||||||||
CR05631 | |||||||||
SS03313 | |||||||||
HBC00464_1 | |||||||||
AS09988 | |||||||||
GP01842 | |||||||||
SRC00540_1 | |||||||||
GW411884.1 | |||||||||
GP01108 | |||||||||
CR06354 | |||||||||
GPC01652_1 | |||||||||
Acan_isotig08768 | |||||||||
BM01518 | |||||||||
Dviv_isotig07870 | |||||||||
GW915714.1 | |||||||||
CV200704.1 | |||||||||
MAC00230_1 | |||||||||
JO468478.1 | |||||||||
FG977858.1 | |||||||||
AE02829 | |||||||||
SSC04094_1 | |||||||||
BMC06835_1 | |||||||||
SR01572 | |||||||||
GT570804.1 | |||||||||
CR00659 | |||||||||
EX911134.1 | |||||||||
JI474575.1 | |||||||||
JI464414.1 | |||||||||
SS02107 | |||||||||
TMC05117_1 | |||||||||
AE01992 | |||||||||
DW718478.1 | |||||||||
BE238932.1 | |||||||||
Acan_isotig17614 | |||||||||
BXC01975_1 | |||||||||
FC545549.1 | |||||||||
JI462209.1 | |||||||||
GP03224 | |||||||||
EL889437.1 | |||||||||
FK804659.1 | |||||||||
JI474832.1 | |||||||||
AYC01140_1 | |||||||||
Dviv_contig17507 | |||||||||
FC815351.1 | |||||||||
CD455450.1 | |||||||||
SSC05731_1 | |||||||||
Tcol_isotig17317 | |||||||||
CSC02141_1 | |||||||||
SRC03646_1 | |||||||||
PT04740 | |||||||||
DA01826 | |||||||||
Associated_feature (33) | |||||||||
Experimental_info | RNAi_result | WBRNAi00103077 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00009413 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00110940 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00057995 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00026914 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00103078 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00103079 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00066558 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00021260 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr8320 | ||||||||
Expr8321 | |||||||||
Expr12128 | |||||||||
Expr1024986 | |||||||||
Expr1031488 | |||||||||
Expr1161419 | |||||||||
Expr2013444 | |||||||||
Expr2031678 | |||||||||
Drives_construct | WBCnstr00008391 | ||||||||
Construct_product (3) | |||||||||
Microarray_results (52) | |||||||||
Expression_cluster (158) | |||||||||
Interaction (38) | |||||||||
Map_info | Map | IV | Position | -5.83327 | Error | 0.101838 | |||
Positive | Positive_clone | Y67D8 | |||||||
Y67D8C | Inferred_automatically | From sequence, transcript, pseudogene data | |||||||
Mapping_data | Multi_point | 3954 | |||||||
Reference (11) | |||||||||
Method | Gene |