WormBase Tree Display for Gene: WBGene00003056
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WBGene00003056 | SMap | S_parent | Sequence | CHROMOSOME_X | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | lon-2 | Person_evidence | WBPerson261 | |||||
Sequence_name | C39E6.1 | ||||||||
Molecular_name | C39E6.1 | ||||||||
C39E6.1.1 | |||||||||
CE35426 | |||||||||
Other_name | CELE_C39E6.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | lon-2 | ||||||||
DB_info | Database | AceView | gene | XF356 | |||||
WormQTL | gene | WBGene00003056 | |||||||
WormFlux | gene | WBGene00003056 | |||||||
NDB | locus_tag | CELE_C39E6.1 | |||||||
Panther | gene | CAEEL|WormBase=WBGene00003056|UniProtKB=Q18530 | |||||||
family | PTHR10822 | ||||||||
NCBI | gene | 180750 | |||||||
RefSeq | protein | NM_076411.8 | |||||||
TREEFAM | TREEFAM_ID | TF353541 | |||||||
TrEMBL | UniProtAcc | Q18530 | |||||||
UniProt_GCRP | UniProtAcc | Q18530 | |||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:30 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | lon | ||||||||
Reference_allele | WBVar00143398 | ||||||||
Allele (213) | |||||||||
Legacy_information | e678 : about 50% longer than wildtype at all stages. ES3. Male bursa slightly elongated ME3 (ME0 at 25x?). NA5 (e405 e434 etc. : similar phenotype to e678). | ||||||||
[C.elegansII] e678 : about 50% longer than wildtype at all stages; some embryonic lethality; ES3. Male bursa slightly elongated, ME3 (ME0 at25C?). OA4: e405, e434, n1346, n1630 etc. (allsimilar to e678). [Brenner 1974] | |||||||||
Strain (224) | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (18) | |||||||||
Ortholog (25) | |||||||||
Structured_description | Concise_description | lon-2 encodes a member of the glypican family of heparan sulfate proteoglycans; during development, lon-2 activity is required in the hypodermis for negative regulation of the DBL-1/BMP signaling pathway that regulates body length; genetic analyses indicate that lon-2 functions upstream of dbl-1, and in vitro studies show that LON-2 can bind mammalian BMP2, suggesting that LON-2 may directly interact with DBL-1 to negatively regulate DBL-1/BMP signaling; in addition to expression in hypodermis, LON-2 is expressed strongly in the intestine, particularly the anterior and posterior cells; LON-2 localizes to the cell surface. | Paper_evidence | WBPaper00029002 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 24 Jan 2007 00:00:00 | ||||||||
Automated_description | Enables growth factor binding activity. Involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; regulation of cell migration; and regulation of mesodermal cell fate specification. Located in cell surface. Expressed in hypodermis and intestine. | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS292 version of WormBase | ||||||||
Date_last_updated | 24 Apr 2024 00:00:00 | ||||||||
Molecular_info (5) | |||||||||
Experimental_info | RNAi_result (23) | ||||||||
Expr_pattern | Expr4651 | ||||||||
Expr4652 | |||||||||
Expr12191 | |||||||||
Expr1011265 | |||||||||
Expr1031435 | |||||||||
Expr1146202 | |||||||||
Expr2013244 | |||||||||
Expr2031475 | |||||||||
Drives_construct | WBCnstr00012150 | ||||||||
WBCnstr00012151 | |||||||||
WBCnstr00021097 | |||||||||
WBCnstr00021479 | |||||||||
WBCnstr00036259 | |||||||||
Construct_product (5) | |||||||||
Microarray_results (21) | |||||||||
Expression_cluster (144) | |||||||||
Interaction (24) | |||||||||
Map_info | Map | X | Position | -6.74013 | Error | 0.007834 | |||
Well_ordered | |||||||||
Positive | Inside_rearr | mnDp30 | |||||||
yDp4 | |||||||||
Positive_clone | C39E6 | Inferred_automatically | From sequence, transcript, pseudogene data | ||||||
F43C9 | |||||||||
Negative | Outside_rearr | mcDf2 | |||||||
Mapping_data (3) | |||||||||
Landmark_gene | |||||||||
Reference (155) | |||||||||
Remark | sequence wsa incorrectly given as F43C9.3 | ||||||||
Method | Gene |