WormBase Tree Display for Gene: WBGene00000018
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WBGene00000018 | SMap | S_parent | Sequence | M79 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 1 | |||||||
Name | CGC_name | abl-1 | |||||||
Sequence_name | M79.1 | ||||||||
Molecular_name (24) | |||||||||
Other_name | CELE_M79.1 | Accession_evidence | NDB | BX284606 | |||||
Public_name | abl-1 | ||||||||
DB_info | Database (15) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 07 Apr 2004 11:29:19 | WBPerson1971 | Event | Imported | Initial conversion from geneace | ||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | abl | ||||||||
Allele (312) | |||||||||
Legacy_information | [C.elegansII] NMK. Major transcript 4.4 kb; sequence (~400 aa) has 62% identity with oncogene v-abl in predicted kinase domain. [Goddard et al. 1986] | ||||||||
Strain | WBStrain00002968 | ||||||||
WBStrain00040670 | |||||||||
WBStrain00040671 | |||||||||
WBStrain00040673 | |||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (65) | |||||||||
Ortholog (35) | |||||||||
Paralog (45) | |||||||||
Structured_description | Concise_description | abl-1 encodes, by alternative splicing, three isoforms of a Src homology(SH) 2 and 3 domain-containing non-receptor tyrosine kinase orthologousto human ABL1 (OMIM:189980, mutated in chronic myeloid leukemia) andABL2 (OMIM:164690); ABL-1 inhibits germline apoptosis induced byradiation or by natural aging, but it has no effect on apoptosis inducedby starvation or by chemical mutagens (ethylnitrosourea,ethylmethanesulfonate, cisplatin, etoposide), or on constitutive('physiological') germline apoptosis; at the same time, ABL-1 isrequired for germline apoptosis induced by oxidative, osmotic orheat-shock stress, and is also required for pathogenesis by Shigellaflexneri infecting the intestine; ABL-1-inhibited apoptosis is confinedto a single gonad arm undergoing radiation, having no nonautonomouseffect on the unirradiated arm; abl-1 is expressed in the germline, inmost or all cells of early embryos, and in postembryonic pharynx, tailganglia and ventral nerve cord; abl-1(ok171) mutants are hypersensitiveto germline apoptosis and resistant to S. flexneri infection; bothabl-1(ok171) phenotypes are phenocopied by c-ABL inhibitors such asSTI-571 (Gleevec); ABL-1-inhibited apoptosis requires active CED-3 andEGL-1, inactive CED-9, and active AKT-1, CEP-1, CLK-1, HUS-1, and MRT-2;abl-1(ok171) has no effect on somatic apoptosis, and abl-1(ok171)mutants are generally normal; abl-1 transcripts are enriched in culturedunc-4::GFP neurons. | Paper_evidence | WBPaper00024301 | |||||
WBPaper00025141 | |||||||||
WBPaper00027170 | |||||||||
WBPaper00027648 | |||||||||
WBPaper00027729 | |||||||||
WBPaper00029085 | |||||||||
Curator_confirmed | WBPerson1843 | ||||||||
WBPerson1823 | |||||||||
WBPerson567 | |||||||||
Date_last_updated | 16 Apr 2007 00:00:00 | ||||||||
Automated_description | Predicted to enable non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including defense response to other organism; negative regulation of DNA damage response, signal transduction by p53 class mediator; and negative regulation of engulfment of apoptotic cell. Predicted to be located in cytoplasm. Expressed in Q cell; germ cell; neurons; pharynx; and ventral nerve cord. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); leukemia (multiple); and lung non-small cell carcinoma. Is an ortholog of human ABL1 (ABL proto-oncogene 1, non-receptor tyrosine kinase) and ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Potential_model | DOID:0050866 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||
DOID:9256 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
DOID:8552 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
DOID:3908 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
DOID:14330 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
DOID:10534 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
DOID:0080630 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
DOID:4914 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
DOID:9119 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:76) | ||||||
Molecular_info | Corresponding_CDS | M79.1a | |||||||
M79.1b | |||||||||
M79.1c | |||||||||
M79.1d | |||||||||
M79.1e | |||||||||
M79.1f | |||||||||
M79.1g | |||||||||
M79.1h | |||||||||
Corresponding_CDS_history | M79.1a:wp83 | ||||||||
M79.1b:wp83 | |||||||||
M79.1c:wp83 | |||||||||
Corresponding_transcript | M79.1a.1 | ||||||||
M79.1b.1 | |||||||||
M79.1c.1 | |||||||||
M79.1d.1 | |||||||||
M79.1e.1 | |||||||||
M79.1f.1 | |||||||||
M79.1g.1 | |||||||||
M79.1h.1 | |||||||||
Other_sequence | ACC11446_1 | ||||||||
MH06257 | |||||||||
TM01377 | |||||||||
JI169172.1 | |||||||||
EX548009.1 | |||||||||
Name_isotig09115 | |||||||||
Oden_isotig17235 | |||||||||
TMC01008_1 | |||||||||
CR09951 | |||||||||
CR09999 | |||||||||
JI165020.1 | |||||||||
CRC03322_1 | |||||||||
CR09872 | |||||||||
Oden_isotig17236 | |||||||||
MHC02694_1 | |||||||||
CRC10628_1 | |||||||||
CRC12454_1 | |||||||||
Dviv_isotig23403 | |||||||||
JI169455.1 | |||||||||
CJC12721_1 | |||||||||
TM03542 | |||||||||
Associated_feature (22) | |||||||||
Experimental_info | RNAi_result (16) | ||||||||
Expr_pattern | Chronogram1126 | ||||||||
Expr3045 | |||||||||
Expr4844 | |||||||||
Expr13648 | |||||||||
Expr1013054 | |||||||||
Expr1030006 | |||||||||
Expr1154769 | |||||||||
Expr2009093 | |||||||||
Expr2027329 | |||||||||
Drives_construct (5) | |||||||||
Construct_product | WBCnstr00000775 | ||||||||
WBCnstr00037793 | |||||||||
Microarray_results (32) | |||||||||
Expression_cluster (112) | |||||||||
Interaction (130) | |||||||||
WBProcess | WBbiopr:00000014 | ||||||||
WBbiopr:00000066 | |||||||||
WBbiopr:00000104 | |||||||||
Map_info | Map | X | Position | 2.34106 | Error | 0.006695 | |||
Positive | Positive_clone | M79 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
MC#191 | |||||||||
Mapping_data | Multi_point | 4134 | |||||||
4652 | |||||||||
Pseudo_map_position | |||||||||
Reference (48) | |||||||||
Method | Gene |