WormBase Tree Display for Gene: WBGene00017920
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WBGene00017920 | SMap | S_parent | Sequence | F29B9 | |||||
---|---|---|---|---|---|---|---|---|---|
Identity | Version | 2 | |||||||
Name | CGC_name | jmjd-1.2 | Person_evidence | WBPerson260 | |||||
Sequence_name | F29B9.2 | ||||||||
Molecular_name | F29B9.2a | ||||||||
F29B9.2a.1 | |||||||||
CE09781 | |||||||||
F29B9.2b | |||||||||
CE27145 | |||||||||
F29B9.2c | |||||||||
CE48643 | |||||||||
F29B9.2b.1 | |||||||||
F29B9.2c.1 | |||||||||
Other_name | CeKDM7A | Paper_evidence | WBPaper00040011 | ||||||
CELE_F29B9.2 | Accession_evidence | NDB | BX284604 | ||||||
Public_name | jmjd-1.2 | ||||||||
DB_info | Database (14) | ||||||||
Species | Caenorhabditis elegans | ||||||||
History | Version_change | 1 | 28 May 2004 13:30:59 | WBPerson1971 | Event | Imported | Initial conversion from CDS class of stlace from WS125 | ||
2 | 30 Sep 2011 16:40:15 | WBPerson2970 | Name_change | CGC_name | jmjd-1.2 | ||||
Status | Live | ||||||||
Gene_info | Biotype | SO:0001217 | |||||||
Gene_class | jmjd | ||||||||
Allele (59) | |||||||||
Strain | WBStrain00037581 | ||||||||
RNASeq_FPKM (74) | |||||||||
GO_annotation (31) | |||||||||
Contained_in_operon | CEOP4136 | ||||||||
Ortholog (45) | |||||||||
Paralog | WBGene00005013 | Caenorhabditis elegans | From_analysis | TreeFam | |||||
Inparanoid_8 | |||||||||
Panther | |||||||||
WormBase-Compara | |||||||||
WBGene00020821 | Caenorhabditis elegans | From_analysis | Panther | ||||||
WormBase-Compara | |||||||||
Structured_description | Concise_description | jmjd-1.2 encodes a PHD and JmjC domain-containing histone demethylase that is homologous to human PHF8, mutations in which are associated with mild X-linked mental retardation (XLMR) and cleft/lip palate; JMJD-1.2 exhibits H3K9me2 and H3K27me2 demethylase activity in vitro and loss-of-function mutations in jmjd-1.2 result in increased levels of H3K9me2 and H3K27me2 in protein lysates from mutant animals; jmjd-1.2 mutant animals also exhibit locomotion defects with increased wavelength, but normal amplitude, of sinusoidal movement; a jmjd-1.2::GFP fusion protein is strongly expressed in neurons where it localizes to the nucleus; fainter expression is also seen in muscle, intestine, and hypodermal cells; jmjd-1.2 expression in neurons is sufficient to rescue the locomotion defects. | Paper_evidence | WBPaper00036110 | |||||
Curator_confirmed | WBPerson1843 | ||||||||
Date_last_updated | 08 Apr 2010 00:00:00 | ||||||||
Automated_description | Enables histone H3K27me2/H3K27me3 demethylase activity; histone H3K9 demethylase activity; and histone binding activity. Involved in mitochondrial unfolded protein response. Located in nucleus. Expressed in several structures, including germ cell; hypodermis; muscle cell; and neurons. Used to study syndromic X-linked intellectual disability. Human ortholog(s) of this gene implicated in melanoma; prostate cancer; and syndromic X-linked intellectual disability Siderius type. Is an ortholog of human KDM7A (lysine demethylase 7A). | Paper_evidence | WBPaper00065943 | ||||||
Curator_confirmed | WBPerson324 | ||||||||
WBPerson37462 | |||||||||
Inferred_automatically | This description was generated automatically by a script based on data from the WS291 version of WormBase | ||||||||
Date_last_updated | 29 Nov 2023 00:00:00 | ||||||||
Disease_info | Experimental_model | DOID:0060309 | Homo sapiens | Paper_evidence | WBPaper00050709 | ||||
Curator_confirmed | WBPerson324 | ||||||||
Date_last_updated | 13 Nov 2017 00:00:00 | ||||||||
Potential_model | DOID:10283 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20672) | |||||
DOID:1909 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:22224) | ||||||
DOID:0060812 | Homo sapiens | Inferred_automatically | Inferred by orthology to human genes with DO annotation (HGNC:20672) | ||||||
Models_disease_asserted | WBDOannot00000447 | ||||||||
Molecular_info | Corresponding_CDS | F29B9.2a | |||||||
F29B9.2b | |||||||||
F29B9.2c | |||||||||
Corresponding_transcript | F29B9.2a.1 | ||||||||
F29B9.2b.1 | |||||||||
F29B9.2c.1 | |||||||||
Other_sequence | Dviv_isotig01576 | ||||||||
Dviv_isotig01599 | |||||||||
Dviv_isotig01600 | |||||||||
Acan_isotig06254 | |||||||||
Dviv_isotig01614 | |||||||||
Dviv_isotig01591 | |||||||||
Dviv_isotig01586 | |||||||||
Dviv_isotig01616 | |||||||||
Dviv_isotig01584 | |||||||||
Dviv_isotig01608 | |||||||||
Dviv_isotig01613 | |||||||||
Dviv_isotig01619 | |||||||||
Dviv_isotig01573 | |||||||||
CR03788 | |||||||||
Dviv_isotig01587 | |||||||||
Dviv_isotig01581 | |||||||||
CRC01144_1 | |||||||||
Dviv_isotig01570 | |||||||||
CR06999 | |||||||||
Dviv_isotig01575 | |||||||||
Dviv_isotig01606 | |||||||||
Dviv_isotig01594 | |||||||||
Dviv_isotig01609 | |||||||||
JI170357.1 | |||||||||
Dviv_isotig01590 | |||||||||
Acan_isotig06255 | |||||||||
Dviv_isotig01592 | |||||||||
Dviv_isotig01582 | |||||||||
SFC00048 | |||||||||
Dviv_isotig01602 | |||||||||
Dviv_isotig01620 | |||||||||
Dviv_isotig01571 | |||||||||
Dviv_isotig01598 | |||||||||
Dviv_isotig01585 | |||||||||
Dviv_isotig01611 | |||||||||
Dviv_isotig01595 | |||||||||
Dviv_isotig01617 | |||||||||
Dviv_isotig01607 | |||||||||
Dviv_isotig01588 | |||||||||
BQ579845.1 | |||||||||
Oden_isotig23918 | |||||||||
Dviv_isotig01574 | |||||||||
Dviv_isotig01569 | |||||||||
BQ563211.1 | |||||||||
Dviv_isotig01612 | |||||||||
Dviv_isotig01583 | |||||||||
Dviv_isotig01577 | |||||||||
Dviv_isotig01589 | |||||||||
Dviv_isotig01580 | |||||||||
Dviv_isotig01597 | |||||||||
Dviv_isotig01615 | |||||||||
CBC09232_1 | |||||||||
CRC01051_1 | |||||||||
Dviv_isotig01593 | |||||||||
Dviv_isotig01603 | |||||||||
Dviv_isotig01618 | |||||||||
Dviv_isotig01579 | |||||||||
Dviv_isotig01596 | |||||||||
JI166936.1 | |||||||||
Dviv_isotig01578 | |||||||||
Dviv_isotig01572 | |||||||||
JI164340.1 | |||||||||
CBC02005_1 | |||||||||
CRC07737_1 | |||||||||
JO472590.1 | |||||||||
Associated_feature | WBsf047593 | ||||||||
WBsf047594 | |||||||||
WBsf645943 | |||||||||
WBsf977089 | |||||||||
WBsf996358 | |||||||||
WBsf228223 | |||||||||
WBsf228224 | |||||||||
Experimental_info | RNAi_result | WBRNAi00082452 | Inferred_automatically | RNAi_primary | |||||
WBRNAi00082611 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00014093 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00045900 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00061627 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00091489 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00001200 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00045899 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00113490 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00031561 | Inferred_automatically | RNAi_primary | |||||||
WBRNAi00112290 | Inferred_automatically | RNAi_primary | |||||||
Expr_pattern | Expr13259 | ||||||||
Expr13525 | |||||||||
Expr1021912 | |||||||||
Expr1037705 | |||||||||
Expr1149803 | |||||||||
Expr2012886 | |||||||||
Expr2031120 | |||||||||
Drives_construct | WBCnstr00026915 | ||||||||
Construct_product | WBCnstr00026915 | ||||||||
Regulate_expr_cluster | WBPaper00049545:rgef-1p-jmjd-1.2(+)_upregulated | ||||||||
WBPaper00049545:rgef-1pjmjd-1.2(+)_downregulated | |||||||||
WBPaper00049545:sur-5p-jmjd-1.2(+)_downregulated | |||||||||
WBPaper00049545:sur-5p-jmjd-1.2(+)_upregulated | |||||||||
WBPaper00050709:jmjd-1.2(tm3713)_regulated | |||||||||
WBPaper00062156:jmjd-1.2(zr1010)_downregulated | |||||||||
WBPaper00062156:jmjd-1.2(zr1010)_upregulated | |||||||||
WBPaper00066083:hlh-17p-jmjd-1.2_downregulated | |||||||||
WBPaper00066083:hlh-17p-jmjd-1.2_upregulated | |||||||||
Antibody | WBAntibody00002197 | ||||||||
WBAntibody00002746 | |||||||||
Microarray_results (27) | |||||||||
Expression_cluster (115) | |||||||||
Interaction (18) | |||||||||
Map_info | Map | IV | Position | 0.6425 | Error | 0.013666 | |||
Positive | Positive_clone | F29B9 | Inferred_automatically | From sequence, transcript, pseudogene data | |||||
Pseudo_map_position | |||||||||
Reference (18) | |||||||||
Remark | Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. | CGC_data_submission | |||||||
Method | Gene |