gcn-1 encodes the C. elegans ortholog of the S. cerevisiae ribosome-associated protein Gcn1p; GCN-1, along with ABCF-3, is required for maintaining the steady-state levels of phosphorylated eIF2alpha, and thus for the translational control of a number of mRNAs; GCN-1 activity is required, in parallel to, or downstream of, the canonical apoptotic pathway, for apoptotic cell death of most somatic cells and germ cells in response to ionizing radiation; in addition, GCN-1 is required for normal growth rates, and spatial organization of germ cells in the gonad; as in S. cerevisiae, GCN-1 physically interacts with ABCF-3, the C. elegans ortholog of budding yeast Gcn20p, and GCN-1 and ABCF-3 are each required for the other's stability; a gcn-1::gfp promoter fusion is expressed in most cells, including germ cells, throughout development.
Predicted to enable protein kinase regulator activity. Involved in positive regulation of peptidyl-serine phosphorylation; regulation of apoptotic process; and regulation of translation. Acts upstream of with a positive effect on positive regulation of gene expression. Acts upstream of or within with a negative effect on negative regulation of translation. Predicted to be located in cytosolic ribosome. Expressed in several structures, including body wall musculature; head neurons; hermaphrodite gonad; intestinal cell; and pharyngeal neurons. Is an ortholog of human GCN1 (GCN1 activator of EIF2AK4).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.