mkrs-2 encodes an ortholog of human B9D2 (OMIM:611951), paralogous to MKRS-1 and MKS-1; MKRS-2 is required for fully normal foraging behavior, and is redundantly required with NPH-4 for roughly normal foraging, and with both NPH-1 and NPH-4 for cilia formation; MKRS-2 is expressed in most ciliated cells, including amphid, phasmid, and labial-quadrant neurons, in a DAF-19-dependent manner; MKRS-2 forms a complex with MKRS-1 and MKS-1 at the base of cilia, and is coexpressed with these proteins in ciliated sensory neurons; MKRS-2 protein is required for proper localization of MKRS-1 and MKS-1 to the transition zone, and binds MKRS-1 in two-hybrid assays.
Involved in several processes, including determination of adult lifespan; larval foraging behavior; and non-motile cilium assembly. Located in ciliary basal body; ciliary transition zone; and dendrite terminus. Expressed in neurons. Used to study Joubert syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome. Is an ortholog of human B9D2 (B9 domain containing 2).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.