WormBase Tree Display for Gene: WBGene00019478

WBGene00019478 SMap: S_parent: Sequence: K07C11
  Identity: Version: 2
    Name: CGC_name: cri-2 Person_evidence: WBPerson16
      Sequence_name: K07C11.5
      Molecular_name (3)
      Other_name: 5I683 Accession_evidence: EMBL AF303253
        tag-225 Person_evidence: WBPerson201
        CELE_K07C11.5 Accession_evidence: NDB BX284605
      Public_name: cri-2
    DB_info: Database: AceView gene 5I683
        WormQTL gene WBGene00019478
        WormFlux gene WBGene00019478
        NDB locus_tag CELE_K07C11.5
        Panther gene CAEEL|WormBase=WBGene00019478|UniProtKB=Q21265
          family PTHR11844
        NCBI gene 179197
        RefSeq protein NM_072712.8
        SwissProt UniProtAcc Q21265
        UniProt_GCRP UniProtAcc Q21265
        OMIM gene 188826
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:01 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 07 May 2008 10:04:34 WBPerson2970 Name_change: CGC_name: cri-2
                Other_name: tag-225
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: cri
    Allele (14)
    Strain: WBStrain00002668
      WBStrain00031717
      WBStrain00036008
      WBStrain00036108
    RNASeq_FPKM (74)
    GO_annotation (13)
    Ortholog: WBGene00053026 Caenorhabditis remanei From_analysis: OMA
            WormBase-Compara
      WBGene00032460 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            WormBase-Compara
      WBGene00091580 Pristionchus pacificus From_analysis: OMA
            WormBase-Compara
      CSP26.g17606 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP29.g17020 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g19866 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g16983 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP39.g4393 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g11945 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cni-cri-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g22210 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00277.g8540 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_03630 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_018782 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g05154 Oscheius tipulae From_analysis: WormBase-Compara
      chrV_pilon.g14929 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00129122 Caenorhabditis japonica From_analysis: WormBase-Compara
      FB:FBgn0025879 Drosophila melanogaster From_analysis: OrthoFinder
            Panther
      ZFIN:ZDB-GENE-030612-1 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
      ZFIN:ZDB-GENE-040426-2655 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-070824-1 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-100603-1 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-160114-61 Danio rerio From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      HGNC:11820 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      HGNC:11821 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:11822 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      HGNC:11823 Homo sapiens From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      MGI:98752 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      MGI:98753 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      MGI:98754 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      MGI:109125 Mus musculus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      RGD:3865 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      RGD:61312 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      RGD:621675 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
      RGD:69077 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Inparanoid
            OrthoFinder
            Panther
    Paralog: WBGene00019476 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: K07C11.5 is orthologous to the human gene SIMILAR TO TISSUE INHIBITOR OF METALLOPROTEINASE 3 (SORSBY FUNDUS DYSTROPHY, PSEUDOINFLAMMATORY) (TIMP3; OMIM:188826), which when mutated leads to disease. Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 06 Aug 2004 00:00:00
      Automated_description: Predicted to enable metalloendopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of membrane protein ectodomain proteolysis and response to organic substance. Predicted to be located in extracellular matrix and extracellular space. Expressed in several structures, including enteric muscle; gonad; hyp12; nerve ring; and tail hypodermis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Duchenne muscular dystrophy; artery disease (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Is an ortholog of human TIMP2 (TIMP metallopeptidase inhibitor 2). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model (39)
  Molecular_info: Corresponding_CDS: K07C11.5
    Corresponding_transcript: K07C11.5.1
    Other_sequence (26)
    Associated_feature: WBsf232074
  Experimental_info: RNAi_result: WBRNAi00050124 Inferred_automatically: RNAi_primary
      WBRNAi00075833 Inferred_automatically: RNAi_primary
      WBRNAi00089115 Inferred_automatically: RNAi_primary
      WBRNAi00033552 Inferred_automatically: RNAi_primary
      WBRNAi00016703 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1148
      Expr4930
      Expr6345
      Expr14700
      Expr1026268
      Expr1038415
      Expr1153825
      Expr2010531
      Expr2028771
    Drives_construct: WBCnstr00003210
      WBCnstr00012343
      WBCnstr00037825
      WBCnstr00040779
    Construct_product: WBCnstr00037825
      WBCnstr00040779
    Microarray_results (18)
    Expression_cluster (173)
    Interaction (20)
  Map_info: Map: V Position: 1.196 Error: 0.008873
    Positive: Positive_clone: K07C11 Inferred_automatically: From sequence, transcript, pseudogene data
    Mapping_data: Multi_point: 4928
        4702
        5659
    Pseudo_map_position
  Reference: WBPaper00031003
    WBPaper00031865
    WBPaper00038491
    WBPaper00041771
    WBPaper00049828
    WBPaper00052194
    WBPaper00055090
    WBPaper00056623
    WBPaper00062715
    WBPaper00063790
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene