WormBase Tree Display for Gene: WBGene00018877

WBGene00018877 SMap: S_parent: Sequence: F55D10
  Identity: Version: 2
    Name: CGC_name: aman-1 Paper_evidence: WBPaper00027768
      Sequence_name: F55D10.1
      Molecular_name: F55D10.1
        F55D10.1.1
        CE28456
      Other_name: CELE_F55D10.1 Accession_evidence: NDB BX284606
      Public_name: aman-1
    DB_info: Database (13)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 05 Jan 2007 17:07:18 WBPerson1847 Name_change: CGC_name: aman-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: aman
    Allele (87)
    Strain: WBStrain00001773
    RNASeq_FPKM (74)
    GO_annotation (11)
    Ortholog: WBGene00051788 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00034996 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00145790 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00096637 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
      WBGene00136793 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00224685 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2321 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g13532 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g21998 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g19072 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g15517 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g23402 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g8400 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g13022 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g26703 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g12417 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00035.g1982 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-aman-1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold622.g6299 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00053.g2683 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_00617 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_024310 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04127 Oscheius tipulae From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g07718 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g12315 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g18519 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g195 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g24005 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g9020 Panagrellus redivivus From_analysis: WormBase-Compara
      Pan_g9700 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0250800 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g18963 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00239857 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00273430 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00264561 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00264563 Strongyloides ratti From_analysis: WormBase-Compara
      FB:FBgn0032066 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0032067 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0032068 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0032069 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0032253 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0027611 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050327-52 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:6826 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:107286 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:3039 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00010284 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
      WBGene00018594 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: aman-1 encodes an ortholog of human lysosomal mannosidase (MAN2B1;OMIM:609458, mutated in alpha-mannosidosis); AMAN-1 is predicted to helpdigest glycoproteins by removing mannose residues from their N-linkedoligosaccharides; AMAN-1 has seven predicted N-glycosylation sites;AMAN-1 is biochemically active in vitro, has optimal activity at pH4-4.5, and is unaffected by Co(II); however, AMAN-1 expressed in Pichiapastoris lacks normal activity, perhaps because it requires othersubunits in vivo; aman-1 is expressed in neurons and intestine. Paper_evidence: WBPaper00006525
            WBPaper00027768
          Curator_confirmed: WBPerson1823
            WBPerson567
          Date_last_updated: 14 Mar 2007 00:00:00
      Automated_description: Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be located in lysosome. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Is an ortholog of human MAN2B1 (mannosidase alpha class 2B member 1). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:3413 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:6826)
  Molecular_info: Corresponding_CDS: F55D10.1
    Corresponding_transcript: F55D10.1.1
    Other_sequence (44)
    Associated_feature: WBsf648039
      WBsf662713
      WBsf1005046
      WBsf1005047
      WBsf1005048
      WBsf1022842
      WBsf235625
  Experimental_info: RNAi_result: WBRNAi00015725 Inferred_automatically: RNAi_primary
      WBRNAi00076484 Inferred_automatically: RNAi_primary
      WBRNAi00048493 Inferred_automatically: RNAi_primary
      WBRNAi00081081 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram257
      Expr6204
      Expr1011721
      Expr1038146
      Expr1152284
      Expr2009320
      Expr2027556
    Drives_construct: WBCnstr00002587
      WBCnstr00026220
    Construct_product (2)
    Microarray_results (20)
    Expression_cluster (176)
    Interaction: WBInteraction000049245
      WBInteraction000253230
      WBInteraction000371124
      WBInteraction000463533
      WBInteraction000573870
  Map_info: Map: X Position: -6.75069
    Positive: Positive_clone: F55D10 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00027768
    WBPaper00029024
    WBPaper00034662
    WBPaper00038491
    WBPaper00055090
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene