WormBase Tree Display for Gene: WBGene00018853

WBGene00018853 SMap: S_parent: Sequence: F55A4
  Identity: Version: 2
    Name: CGC_name: sec-22 Person_evidence: WBPerson3132
      Sequence_name: F55A4.1
      Molecular_name (3)
      Other_name: CELE_F55A4.1 Accession_evidence: NDB BX284606
      Public_name: sec-22
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 26 Mar 2010 11:10:22 WBPerson2970 Name_change: CGC_name: sec-22
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sec
    Allele (23)
    Strain: WBStrain00001453
      WBStrain00002575
      WBStrain00032937
    RNASeq_FPKM (74)
    GO_annotation (25)
    Ortholog: WBGene00029935 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00060184 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00145361 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00132103 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00234037 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g2384 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g215 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g820 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP31.g6143 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g16607 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g3481 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g8199 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g11213 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00252.g7921 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-sec-22 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold548.g3559 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01262.g19667 Caenorhabditis sinica From_analysis: WormBase-Compara
      Csp5_scaffold_06126.g36111 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_03162 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_022250 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g04131 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g2045 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_X0012200 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrX_pilon.g18371 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00239351 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00258081 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00295485 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000004258 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0260855 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-010724-3 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-5488 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10700 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1338759 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1309988 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00004897 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004898 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00004899 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00007200 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00014084 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00015164 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00022077 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00044062 Caenorhabditis elegans From_analysis: WormBase-Compara
    Structured_description: Automated_description: Predicted to enable SNAP receptor activity. Involved in IRE1-mediated unfolded protein response. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment and organelle membrane. Predicted to be part of SNARE complex. Expressed in somatic cell and tail. Used to study Parkinson's disease. Is an ortholog of human SEC22B (SEC22 homolog B, vesicle trafficking protein). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:14330 Homo sapiens Paper_evidence: WBPaper00031384
          Curator_confirmed: WBPerson324
          Date_last_updated: 24 Jul 2013 00:00:00
    Disease_relevance: In an elegans model of Parkinson''s disease, where human alpha-synuclein was overexpressed, RNA interference studies showed that the elegans sec-22/SEC22A (homolog of yeast sec22p vesicle trafficking protein), significantly protected against age- and dose-dependent degeneration in the dopamine neurons of transgenic worms; such models allow the identification of human modifier proteins of alpha-synuclein dependent misfolding and neurodegeneration, these proteins may also be new potential targets for therapeutic intervention. Homo sapiens Paper_evidence: WBPaper00031384
          Accession_evidence: OMIM 612442
          Curator_confirmed: WBPerson324
          Date_last_updated: 24 Jul 2013 00:00:00
  Models_disease_in_annotation: WBDOannot00000216
  Molecular_info: Corresponding_CDS: F55A4.1
    Corresponding_transcript: F55A4.1.1
    Other_sequence (41)
    Associated_feature: WBsf647814
      WBsf235303
      WBsf235304
  Experimental_info: RNAi_result: WBRNAi00076480 Inferred_automatically: RNAi_primary
      WBRNAi00110503 Inferred_automatically: RNAi_primary
      WBRNAi00032843 Inferred_automatically: RNAi_primary
      WBRNAi00015681 Inferred_automatically: RNAi_primary
      WBRNAi00048433 Inferred_automatically: RNAi_primary
      WBRNAi00110527 Inferred_automatically: RNAi_primary
      WBRNAi00110515 Inferred_automatically: RNAi_primary
    Expr_pattern: Chronogram1322
      Chronogram1425
      Expr6194
      Expr13362
      Expr1022198
      Expr1038135
      Expr1152220
      Expr2015712
      Expr2033944
    Drives_construct: WBCnstr00004232
      WBCnstr00004233
      WBCnstr00026240
      WBCnstr00039343
    Construct_product: WBCnstr00006220
      WBCnstr00006227
      WBCnstr00026240
      WBCnstr00039343
    Microarray_results (19)
    Expression_cluster (141)
    Interaction (51)
  Map_info: Map: X Position: -18.7988 Error: 0.009491
    Positive: Positive_clone: F55A4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00031384
    WBPaper00038491
    WBPaper00042644
    WBPaper00043668
    WBPaper00050534
    WBPaper00055090
    WBPaper00061547
    WBPaper00066137
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene