WormBase Tree Display for Gene: WBGene00018635

WBGene00018635 SMap: S_parent: Sequence: CHROMOSOME_IV
  Identity: Version: 3
    Name: CGC_name: nprl-2 Person_evidence: WBPerson237
      Sequence_name: F49E8.1
      Molecular_name: F49E8.1a
        F49E8.1a.1
        CE33650
        F49E8.1b
        CE51825
        F49E8.1b.1
      Other_name: CELE_F49E8.1 Accession_evidence: NDB BX284604
      Public_name: nprl-2
    DB_info: Database: AceView gene 4I323
        WormQTL gene WBGene00018635
        WormFlux gene WBGene00018635
        NDB locus_tag CELE_F49E8.1
        Panther gene CAEEL|WormBase=WBGene00018635|UniProtKB=W6RQZ3
          family PTHR12991
        NCBI gene 177532
        RefSeq protein NM_001392334.1
            NM_001392333.1
        TrEMBL UniProtAcc W6SBD7
            W6RQZ3
        UniProt_GCRP UniProtAcc W6RQZ3
        OMIM gene 607072
    Species: Caenorhabditis elegans
    History: Version_change: 1 28 May 2004 13:31:00 WBPerson1971 Event: Imported: Initial conversion from CDS class of stlace from WS125
        2 11 Apr 2012 13:49:30 WBPerson2970 Name_change: CGC_name: nprl-2
        3 06 Mar 2018 14:46:01 WBPerson4025 Event: Split_into: WBGene00302976
      Split_into: WBGene00302976
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: nprl
    Allele (33)
    RNASeq_FPKM (74)
    GO_annotation: 00105446
      00105447
      00105448
      00105449
      00105450
      00105451
      00105452
    Contained_in_operon: CEOP5598
    Ortholog: WBGene00028269 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00164959 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00133263 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00071947 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00224489 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g11100 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g4839 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g16110 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g18832 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g17365 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g21760 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g9554 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g15757 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g10606 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g16785 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP38.g19262 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g5786 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g19453 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00099.g4299 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-nprl-2 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold630.g21205 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01790.g23159 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_22646 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_013974 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g01929 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g3614 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_40301700 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g10867 Caenorhabditis elegans From_analysis: WormBase-Compara
      nigoni.pc_2016.07.11_009.g27333 Caenorhabditis nigoni From_analysis: WormBase-Compara
      nigoni.pc_2016.07.11_009.g27367 Caenorhabditis nigoni From_analysis: WormBase-Compara
      WBGene00239682 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00304551 Pristionchus pacificus From_analysis: WormBase-Compara
      WBGene00294684 Trichuris muris From_analysis: WormBase-Compara
      WBGene00296494 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000000788 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      FB:FBgn0030800 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-060825-93 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      HGNC:24969 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      MGI:1914482 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
      RGD:1308927 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
    Structured_description: Automated_description: Predicted to contribute to GTPase activator activity. Predicted to be involved in cellular response to amino acid starvation; negative regulation of TORC1 signaling; and positive regulation of autophagy. Predicted to be located in vacuolar membrane. Predicted to be part of GATOR1 complex. Human ortholog(s) of this gene implicated in focal epilepsy. Is an ortholog of human NPRL2 (NPR2 like, GATOR1 complex subunit). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:2234 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:24969)
  Molecular_info: Corresponding_CDS: F49E8.1a
      F49E8.1b
    Corresponding_CDS_history: F49E8.1:wp97
      F49E8.1:wp241
      F49E8.1a:wp256
      F49E8.1b:wp256
      F49E8.1c:wp264
    Corresponding_transcript: F49E8.1a.1
      F49E8.1b.1
    Other_sequence (24)
    Associated_feature (6)
  Experimental_info: RNAi_result: WBRNAi00061819 Inferred_automatically: RNAi_primary
      WBRNAi00032550 Inferred_automatically: RNAi_primary
      WBRNAi00015331 Inferred_automatically: RNAi_primary
      WBRNAi00047868 Inferred_automatically: RNAi_primary
    Expr_pattern: Expr1019604
      Expr1038019
      Expr1151698
      Expr2014430
      Expr2032671
    Drives_construct: WBCnstr00026371
    Construct_product: WBCnstr00026371
    Microarray_results (22)
    Expression_cluster (82)
    Interaction (35)
  Map_info: Map: IV Position: 3.35571
    Positive: Positive_clone: F49E8 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00038491
    WBPaper00042436
    WBPaper00052740
    WBPaper00055090
    WBPaper00055173
    WBPaper00061251
    WBPaper00064505
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene