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WormBase Tree Display for Gene: WBGene00012550

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Name Class

WBGene00012550SMapS_parentSequenceY37D8A
IdentityVersion3
NameCGC_namespcs-2
Sequence_nameY37D8A.10
Molecular_nameY37D8A.10
Y37D8A.10.1
CE20214
Other_namehpo-21
CELE_Y37D8A.10Accession_evidenceNDBBX284603
Public_namespcs-2
DB_infoDatabaseAceViewgene3N965
WormQTLgeneWBGene00012550
WormFluxgeneWBGene00012550
NDBlocus_tagCELE_Y37D8A.10
PanthergeneCAEEL|WormBase=WBGene00012550|UniProtKB=Q9XWW1
familyPTHR13085
NCBIgene176703
RefSeqproteinNM_067275.8
SwissProtUniProtAccQ9XWW1
TREEFAMTREEFAM_IDTF314545
UniProt_GCRPUniProtAccQ9XWW1
SpeciesCaenorhabditis elegans
HistoryVersion_change126 May 2004 16:54:53WBPerson1971EventImportedInitial conversion from CDS class of WS125
226 Apr 2011 13:31:47WBPerson2970Name_changeCGC_namehpo-21
312 Nov 2018 16:28:49WBPerson1983Name_changeCGC_namespcs-2
Other_namehpo-21
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classspcs
Allele (17)
StrainWBStrain00037795
RNASeq_FPKM (74)
GO_annotation (11)
OrthologWBGene00035909Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00063438Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00153224Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00156935Caenorhabditis brenneriFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00138058Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00226642Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g4261Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g10455Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g16787Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g1858Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g10472Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g5792Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g5865Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g6138Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g6861Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g24474Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00616.g12811Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-hpo-21Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold629.g16053Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_02081.g24755Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_14518Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_010957Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g11325Oscheius tipulaeFrom_analysisWormBase-Compara
Pan_g22897Panagrellus redivivusFrom_analysisWormBase-Compara
Sp34_30293200Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrIII_pilon.g9253Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00238985Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00304313Pristionchus pacificusFrom_analysisWormBase-Compara
WBGene00263748Strongyloides rattiFrom_analysisWormBase-Compara
SGD:S000004519Saccharomyces cerevisiaeFrom_analysisEnsEMBL-Compara
Hieranoid
OrthoFinder
Panther
FB:FBgn0030306Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-050320-32Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:28962Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:1913874Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
RGD:1311253Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
Structured_descriptionAutomated_descriptionInvolved in IRE1-mediated unfolded protein response. Located in sarcoplasmic reticulum. Used to study Parkinson's disease. Is an ortholog of human SPCS2 (signal peptidase complex subunit 2).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:14330Homo sapiensPaper_evidenceWBPaper00041253
Curator_confirmedWBPerson324
Date_last_updated20 Nov 2013 00:00:00
Disease_relevanceIn elegans, hpo-21, orthologous to human SPCS1, is involved with several other hpo genes in the protective response against pore-forming toxins; hpo-21 has been shown to have a protective effect in an elegans model for alpha-synuclein (alpha-syn) toxicity (implicated in Parkinson''s disease, and other alpha-synucleinopathies); this model consists of overexpression of human alpha-syn fused to green fluorescent protein (GFP) in body wall muscle cells, resulting in age-dependent alpha-syn misfolding in the cytoplasm; co-expression of a chaperone, TOR-2, in this system reduces alpha-syn-GFP misfolding, providing a genetic background in which the enhancement of alpha-syn misfolding is easily visualized; hpo-21 was identified as a interactor of catp-6/ATP13A2; deficiency of catp-6/ATP13A2 and its interactors, including hpo-21, exacerbates alpha-syn misfolding in the above elegans model.Homo sapiensPaper_evidenceWBPaper00038231
WBPaper00041253
Curator_confirmedWBPerson324
Date_last_updated20 Nov 2013 00:00:00
Models_disease_in_annotationWBDOannot00000252
Molecular_infoCorresponding_CDSY37D8A.10
Corresponding_transcriptY37D8A.10.1
Other_sequence (49)
Associated_featureWBsf645677
WBsf225936
WBsf225937
Experimental_infoRNAi_result (16)
Expr_patternExpr9419
Expr1014401
Expr1035553
Expr1159394
Expr2012563
Expr2030800
Drives_constructWBCnstr00029908
Construct_productWBCnstr00013984
WBCnstr00029908
Microarray_results (20)
Expression_cluster (90)
Interaction (55)
Map_info (3)
ReferenceWBPaper00024200
WBPaper00035925
WBPaper00038444
WBPaper00038491
WBPaper00055090
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene