inos-1 encodes the C. elegans myo-inositol-1-phosphate (MIP) synthase ortholog; by homology, the product of inos-1 is predicted to function in de novo inositol biosynthesis by catalyzing the conversion of glucose-6-phosphate to inositol-1-phosphate; loss of inos-1 activity via RNAi has been reported to result in low levels of embryonic lethality, larval lethality, slow growth, uncoordinated locomotion, and a substantial increase in fat content; loss of inos-1 activity also results in a slight increase in the variability of the defecation cycle length, although this increase is not statistically significant; in situ hybridization studies reveal that inos-1 mRNA is expressed faintly in the germline.
Predicted to enable inositol-3-phosphate synthase activity. Predicted to be involved in inositol biosynthetic process. Predicted to be located in cytoplasm. Expressed in germ line. Is an ortholog of human ISYNA1 (inositol-3-phosphate synthase 1).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.