WormBase Tree Display for Gene: WBGene00010775

WBGene00010775 SMap: S_parent: Sequence: K11E4
  Identity: Version: 2
    Name: CGC_name: poml-1 Person_evidence: WBPerson10017
            WBPerson95
      Sequence_name: K11E4.3
      Molecular_name: K11E4.3
        K11E4.3.1
        CE44204
      Other_name: CELE_K11E4.3 Accession_evidence: NDB BX284606
      Public_name: poml-1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:51 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 13 Apr 2012 16:55:20 WBPerson2970 Name_change: CGC_name: poml-1
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: poml
    Allele (81)
    Strain: WBStrain00032454
    RNASeq_FPKM (74)
    GO_annotation: 00071586
      00071587
      00071588
      00071589
      00071590
      00118109
    Ortholog: WBGene00029445 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00065296 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00226397 Brugia malayi From_analysis: WormBase-Compara
      CSP21.g11897 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g8559 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g18083 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g20401 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g11164 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g6322 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP39.g26175 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g13310 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      GCK72_025760 Caenorhabditis remanei From_analysis: WormBase-Compara
      Pan_g18773 Panagrellus redivivus From_analysis: WormBase-Compara
      chrX_pilon.g20467 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00248643 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00265830 Strongyloides ratti From_analysis: WormBase-Compara
      ZFIN:ZDB-GENE-030131-7116 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-040912-6 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-050522-353 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      ZFIN:ZDB-GENE-071004-70 Danio rerio From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      HGNC:9204 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      HGNC:9205 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      HGNC:9206 Homo sapiens From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:103295 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:106686 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      MGI:106687 Mus musculus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      RGD:620062 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      RGD:1309954 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
      RGD:1302965 Rattus norvegicus From_analysis: EnsEMBL-Compara
            OrthoFinder
            Panther
    Paralog: WBGene00003170 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00077701 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00017089 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
      WBGene00044697 Caenorhabditis elegans From_analysis: TreeFam
            Panther
            WormBase-Compara
    Structured_description: Concise_description: poml-1 is homologous to the human Paraoxonase family of genes (PON1, PON2, PON3), which are arylesterases that mainly hydrolyze paroxon to produce p-nitrophenol. Paroxon is an organophosphorus anticholinesterase compound that is produced in vivo by oxidation of the insecticide parathion; the PON genes also hydrolyze the toxic metabolites of a variety of organophosphorus insecticides. Paper_evidence: WBPaper00005591
          Curator_confirmed: WBPerson324
            WBPerson567
          Date_last_updated: 06 May 2013 00:00:00
      Automated_description: Enables protein folding chaperone. Involved in protein maturation by protein folding. Located in rough endoplasmic reticulum. Expressed in neurons. Used to study neurodegenerative disease. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; autoimmune disease (multiple); eye disease (multiple); and hematologic cancer (multiple). Is an ortholog of human PON1 (paraoxonase 1); PON2 (paraoxonase 2); and PON3 (paraoxonase 3). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Experimental_model: DOID:1289 Homo sapiens Paper_evidence: WBPaper00049330
          Curator_confirmed: WBPerson324
          Date_last_updated: 13 Mar 2023 00:00:00
    Potential_model (51)
    Disease_relevance: Human pon genes, PON1, PON2 and PON3 are arylesterases that are involved in the detoxification of the metabolites of organophosphorus insecticides; mutations in PON1 have been implicated in coronary artery disease and the microvascular complications of diabetes. Homo sapiens Accession_evidence: OMIM 612633
          Curator_confirmed: WBPerson324
          Date_last_updated: 06 May 2013 00:00:00
  Models_disease_in_annotation: WBDOannot00000170
  Molecular_info: Corresponding_CDS: K11E4.3
    Corresponding_CDS_history: K11E4.3:wp208
    Corresponding_transcript: K11E4.3.1
    Associated_feature: WBsf654539
      WBsf671212
  Experimental_info: RNAi_result: WBRNAi00017015 Inferred_automatically: RNAi_primary
      WBRNAi00050604 Inferred_automatically: RNAi_primary
    Expr_pattern (7)
    Drives_construct: WBCnstr00009826
      WBCnstr00014378
      WBCnstr00021619
      WBCnstr00022647
      WBCnstr00022762
      WBCnstr00031156
    Construct_product: WBCnstr00009826
      WBCnstr00014378
      WBCnstr00022647
      WBCnstr00022762
      WBCnstr00031156
    Microarray_results (18)
    Expression_cluster (64)
    Interaction (25)
  Map_info: Map: X Position: 14.46
    Positive: Positive_clone: K11E4 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00034024
    WBPaper00034065
    WBPaper00039337
    WBPaper00047789
    WBPaper00048712
    WBPaper00049330
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene