WormBase Tree Display for Gene: WBGene00009218

WBGene00009218 SMap: S_parent: Sequence: F28D1
  Identity: Version: 2
    Name: CGC_name: acs-20 Person_evidence: WBPerson237
            WBPerson2239
      Sequence_name: F28D1.9
      Molecular_name: F28D1.9
        F28D1.9.1
        CE47963
      Other_name: CELE_F28D1.9 Accession_evidence: NDB BX284604
      Public_name: acs-20
    DB_info: Database: AceView gene 4N158
        WormQTL gene WBGene00009218
        WormFlux gene WBGene00009218
        NDB locus_tag CELE_F28D1.9
        Panther gene CAEEL|WormBase=WBGene00009218|UniProtKB=Q19878
          family PTHR43107
        NCBI gene 178190
        RefSeq protein NM_069966.10
        TrEMBL UniProtAcc Q19878
        UniProt_GCRP UniProtAcc Q19878
    Species: Caenorhabditis elegans
    History: Version_change: 1 26 May 2004 16:54:50 WBPerson1971 Event: Imported: Initial conversion from CDS class of WS125
        2 11 Sep 2008 09:57:25 WBPerson2970 Name_change: CGC_name: acs-20
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: acs
    Allele (88)
    Strain (2)
    RNASeq_FPKM (74)
    GO_annotation: 00066220
      00066221
      00066222
      00066223
      00066224
      00066225
      00066226
      00066227
    Ortholog: WBGene00071916 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00026207 Caenorhabditis briggsae From_analysis: OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00140059 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00134007 Caenorhabditis japonica From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00194110 Caenorhabditis brenneri From_analysis: TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00098434 Pristionchus pacificus From_analysis: OMA
      CBOVI.g11617 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g4067 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g5353 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g11086 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g7784 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g15788 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g4608 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g4500 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g21061 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g22709 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00588.g12534 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_08018.g21242 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-acs-20 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold629.g12699 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_01712.g22669 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_04812 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_014299 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g03017 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g17008 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_40243100 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g12066 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00266108 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00284943 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000000245 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoInspector
            PhylomeDB
            SonicParanoid
      FB:FBgn0265187 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0034999 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      FB:FBgn0267828 Drosophila melanogaster From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050320-112 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-050417-248 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-061013-672 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10998 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10995 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1347098 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1347347 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:620927 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1307383 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog (17)
    Structured_description: Concise_description: acs-20 encodes a protein homologous to the mammalian FATP1 and FATP4 fatty acid transport proteins (FATP)/very long chain fatty acid acyl-CoA synthetases; acs-20 activity is required for proper cuticle development, specifically formation of a cuticle surface barrier that prevents penetration of small molecules; acs-20 may affect cuticle development via its role in incorporation of very long chain fatty acids, but not other fatty acids, into sphingomyelin; acs-20; acs-22 doubly mutant animals have moresevere cuticle barrier defects than acs-20 single mutants, suggesting that the two genes function redundantly; acs-20 defects can be rescued by human Fatp4; an ACS-20::GFP fusion protein is expressed in the hyp7 and seam hypodermis, as well as the vulval and anal muscles; in hypodermal cells, ACS-20 localizes in a reticular pattern suggestive of localization to the endoplasmic reticulum. Paper_evidence: WBPaper00035868
          Curator_confirmed: WBPerson1843
          Date_last_updated: 03 Feb 2010 00:00:00
      Automated_description: Predicted to enable long-chain fatty acid transporter activity and long-chain fatty acid-CoA ligase activity. Predicted to be involved in triglyceride homeostasis. Located in intracellular membrane-bounded organelle. Expressed in anal depressor muscle; anal sphincter muscle; head; hyp7 syncytium; and seam cell. Human ortholog(s) of this gene implicated in obesity. Is an ortholog of human SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:9970 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10998)
  Molecular_info: Corresponding_CDS: F28D1.9
    Corresponding_CDS_history: F28D1.9:wp154
    Corresponding_transcript: F28D1.9.1
    Other_sequence (33)
    Associated_feature (13)
  Experimental_info: RNAi_result (23)
    Expr_pattern: Chronogram984
      Expr5903
      Expr8893
      Expr8895
      Expr1026843
      Expr1034021
      Expr1149741
      Expr2009210
      Expr2027447
    Drives_construct: WBCnstr00002507
      WBCnstr00007265
      WBCnstr00013587
      WBCnstr00013589
      WBCnstr00022750
      WBCnstr00022752
      WBCnstr00032361
    Construct_product: WBCnstr00007265
      WBCnstr00013589
      WBCnstr00022752
      WBCnstr00022754
      WBCnstr00032361
    Microarray_results (17)
    Expression_cluster (233)
    Interaction (173)
  Map_info: Map: IV Position: 5.90843 Error: 0.002883
    Positive: Positive_clone: F28D1 Inferred_automatically: From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference (12)
  Remark: Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene