leo-1 encodes the C. elegans ortholog of mammalian and Saccharomyces cerevisiae LEO1 that is a member of the PAF1 (Polymerase-Associated Factor 1) complex; by homology LEO-1 is predicted to function in the regulation of transcription.
Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Predicted to be involved in positive regulation of transcription elongation by RNA polymerase II. Located in nucleus. Is an ortholog of human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.