vha-4 encodes an ortholog of subunit c'' of the membrane-bound (V0)domain of vacuolar proton-translocating ATPase (V-ATPase); VHA-4 is apredicted V-ATPase transmembrane rotor component; VHA-4 is paralogous tothe c subunits VHA-1/-2/-3, and is predicted to help carry protons fromthe cytosol to a-subunits (VHA-5, VHA-6, VHA-7, or UNC-32) fortransmembrane export; VHA-4 is required for ovulation and embryogenesis,since vha-4(RNAi) animals are sterile with polyploid, unmatured oocytesand dead progeny; VHA-4 is required for alae formation, like the V0subunits VHA-1 and VHA-5, but not like the V1 subunits VHA-8 or VHA-13;vha-4 is expressed in the excretory cell, the rectum, and a pair ofcells near the anus.
Predicted to enable proton transmembrane transporter activity. Involved in embryo development. Predicted to be located in membrane. Predicted to be part of proton-transporting two-sector ATPase complex, proton-transporting domain. Expressed in excretory cell and rectum. Is an ortholog of human ATP6V0B (ATPase H+ transporting V0 subunit b).
Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.