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WormBase Tree Display for Gene: WBGene00006721

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Name Class

WBGene00006721EvidencePerson_evidenceWBPerson2549
WBPerson6733
SMapS_parentSequenceF46E10
IdentityVersion1
NameCGC_nameubh-1
Sequence_nameF46E10.8
Molecular_nameF46E10.8
F46E10.8.1
CE20818
Other_nameF46E10.fCurator_confirmedWBPerson1983
RemarkOld cosmid naming mapped via unique overlapping PCR_product on CDSs
CELE_F46E10.8Accession_evidenceNDBBX284605
Public_nameubh-1
DB_infoDatabase (13)
SpeciesCaenorhabditis elegans
HistoryVersion_change107 Apr 2004 11:29:41WBPerson1971EventImportedInitial conversion from geneace
StatusLive
Gene_infoBiotypeSO:0001217
Gene_classubh
Allele (25)
RNASeq_FPKM (74)
GO_annotation (21)
Contained_in_operonCEOP5120
OrthologWBGene00052169Caenorhabditis remaneiFrom_analysisOMA
TreeFam
Inparanoid_8
WormBase-Compara
WBGene00038250Caenorhabditis briggsaeFrom_analysisHillier-set
OrthoMCL
OMA
Inparanoid_8
WormBase-Compara
WBGene00130532Caenorhabditis japonicaFrom_analysisTreeFam
Inparanoid_8
WormBase-Compara
WBGene00085725Caenorhabditis remaneiFrom_analysisTreeFam
WBGene00147434Caenorhabditis brenneriFrom_analysisOMA
WormBase-Compara
WBGene00038251Caenorhabditis briggsaeFrom_analysisWormBase-Compara
WBGene00234107Brugia malayiFrom_analysisWormBase-Compara
CBOVI.g1770Caenorhabditis bovisFrom_analysisWormBase-Compara
CSP21.g5609Caenorhabditis parvicaudaFrom_analysisWormBase-Compara
CSP26.g8479Caenorhabditis zanzibariFrom_analysisWormBase-Compara
CSP28.g8738Caenorhabditis panamensisFrom_analysisWormBase-Compara
CSP29.g5505Caenorhabditis beceiFrom_analysisWormBase-Compara
CSP31.g11261Caenorhabditis uteleiaFrom_analysisWormBase-Compara
CSP32.g14907Caenorhabditis sulstoniFrom_analysisWormBase-Compara
CSP38.g10695Caenorhabditis quiockensisFrom_analysisWormBase-Compara
CSP39.g8793Caenorhabditis waitukubuliFrom_analysisWormBase-Compara
CSP40.g11359Caenorhabditis tribulationisFrom_analysisWormBase-Compara
Cang_2012_03_13_00182.g6386Caenorhabditis angariaFrom_analysisWormBase-Compara
Cni-ubh-1Caenorhabditis nigoniFrom_analysisWormBase-Compara
Csp11.Scaffold630.g17520Caenorhabditis tropicalisFrom_analysisWormBase-Compara
Csp5_scaffold_00013.g854Caenorhabditis sinicaFrom_analysisWormBase-Compara
FL83_10795Caenorhabditis latensFrom_analysisWormBase-Compara
GCK72_017939Caenorhabditis remaneiFrom_analysisWormBase-Compara
OTIPU.nOt.2.0.1.g00876Oscheius tipulaeFrom_analysisWormBase-Compara
Sp34_50214400Caenorhabditis inopinataFrom_analysisWormBase-Compara
chrV_pilon.g14451Caenorhabditis elegansFrom_analysisWormBase-Compara
WBGene00242777Onchocerca volvulusFrom_analysisWormBase-Compara
WBGene00258134Strongyloides rattiFrom_analysisWormBase-Compara
SGD:S000003860Saccharomyces cerevisiaeFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OrthoInspector
Panther
SonicParanoid
FB:FBgn0010288Drosophila melanogasterFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
ZFIN:ZDB-GENE-030131-3844Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ZFIN:ZDB-GENE-050522-158Danio rerioFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
HGNC:12513Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
HGNC:12515Homo sapiensFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
PhylomeDB
SonicParanoid
MGI:103149Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
MGI:1355274Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
MGI:1890440Mus musculusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
RGD:3928Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
RGD:1561196Rattus norvegicusFrom_analysisEnsEMBL-Compara
Hieranoid
Inparanoid
OMA
OrthoFinder
OrthoInspector
Panther
SonicParanoid
ParalogWBGene00006722Caenorhabditis elegansFrom_analysisTreeFam
Panther
WormBase-Compara
WBGene00006723Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
WBGene00006724Caenorhabditis elegansFrom_analysisPanther
WormBase-Compara
Structured_descriptionConcise_descriptionubh-1 encodes a putative ubiquitin C-terminal hydrolase orthologous to human UCHL1, that catalyzes the hydrolysis of C-terminal ubiquitinyl esters; C. elegans has three ubiquitin C-terminal hydrolase orthologs-ubh-1, ubh-2 and ubh-3; studies indicate that the ubh genes maybe be involved in aging, as they play a role in cellular senescence.Paper_evidenceWBPaper00027616
WBPaper00035660
Curator_confirmedWBPerson324
WBPerson1823
WBPerson567
Date_last_updated15 Jul 2013 00:00:00
Automated_descriptionEnables deNEDDylase activity and deubiquitinase activity. Involved in negative regulation of dauer larval development; positive regulation of transforming growth factor beta receptor signaling pathway; and protein deneddylation. Predicted to be located in cytoplasm. Expressed in amphid neurons and intestinal cell. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia (multiple). Is an ortholog of human UCHL1 (ubiquitin C-terminal hydrolase L1) and UCHL3 (ubiquitin C-terminal hydrolase L3).Paper_evidenceWBPaper00065943
Curator_confirmedWBPerson324
WBPerson37462
Inferred_automaticallyThis description was generated automatically by a script based on data from the WS291 version of WormBase
Date_last_updated29 Nov 2023 00:00:00
Disease_infoExperimental_modelDOID:14330Homo sapiensPaper_evidenceWBPaper00035660
Accession_evidenceOMIM613643
Curator_confirmedWBPerson324
Date_last_updated15 Jul 2013 00:00:00
Potential_modelDOID:10652Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
DOID:0070455Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
DOID:14330Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
DOID:0112344Homo sapiensInferred_automaticallyInferred by orthology to human genes with DO annotation (HGNC:12513)
Disease_relevanceMutations in human ubiquitin C-terminal hydrolase L1 (UCHL1/PARK5; neuron specific) are associated with Parkinson''s disease (PD); UCH-L1 protects against protein aggregation disorders such as Alzheimer disease and PD and is part of the ubiquitin proteasome system; C. elegans is used as a model system to study the genetic interactions and molecular functions of PARK protein orthologs; studies that knock-down the ubh genes in elegans (ubh-1, ubh-2, ubh-3) indicate that they are involved in cellular senescence and thus aging.Homo sapiensPaper_evidenceWBPaper00027616
WBPaper00035660
Accession_evidenceOMIM613643
191342
Curator_confirmedWBPerson324
Date_last_updated15 Jul 2013 00:00:00
Models_disease_in_annotationWBDOannot00000209
Molecular_infoCorresponding_CDSF46E10.8
Corresponding_transcriptF46E10.8.1
Other_sequence (36)
Associated_featureWBsf669046
WBsf669047
WBsf669048
WBsf1000286
WBsf233815
Experimental_infoRNAi_resultWBRNAi00102982Inferred_automaticallyRNAi_primary
WBRNAi00102992Inferred_automaticallyRNAi_primary
WBRNAi00102972Inferred_automaticallyRNAi_primary
WBRNAi00015095Inferred_automaticallyRNAi_primary
WBRNAi00056335Inferred_automaticallyRNAi_primary
WBRNAi00094630Inferred_automaticallyRNAi_primary
WBRNAi00047527Inferred_automaticallyRNAi_primary
WBRNAi00076438Inferred_automaticallyRNAi_primary
Expr_pattern (5)
Drives_constructWBCnstr00042221
Construct_productWBCnstr00042221
Microarray_results (17)
Expression_cluster (153)
Interaction (17)
Map_infoMapVPosition-0.032234Error0.006589
PositivePositive_cloneF46E10Inferred_automaticallyFrom sequence, transcript, pseudogene data
Pseudo_map_position
ReferenceWBPaper00010020
WBPaper00025802
WBPaper00027616
WBPaper00030133
WBPaper00030965
WBPaper00038491
WBPaper00055090
WBPaper00060977
WBPaper00063803
WBPaper00064934
RemarkMap position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC.CGC_data_submission
MethodGene