WormBase Tree Display for Gene: WBGene00004755

WBGene00004755 SMap: S_parent: Sequence: F12F6
  Identity: Version: 1
    Name: CGC_name: sec-24.1 Person_evidence: WBPerson297
      Sequence_name: F12F6.6
      Molecular_name: F12F6.6
        F12F6.6.1
        CE05594
      Other_name: CELE_F12F6.6 Accession_evidence: NDB BX284604
      Public_name: sec-24.1
    DB_info: Database (11)
    Species: Caenorhabditis elegans
    History: Version_change: 1 07 Apr 2004 11:29:36 WBPerson1971 Event: Imported: Initial conversion from geneace
    Status: Live
  Gene_info: Biotype: SO:0001217
    Gene_class: sec
    Allele (47)
    RNASeq_FPKM (74)
    GO_annotation (14)
    Contained_in_operon: CEOP4452
    Ortholog: WBGene00062622 Caenorhabditis remanei From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00028453 Caenorhabditis briggsae From_analysis: Hillier-set
            OrthoMCL
            OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00103135 Pristionchus pacificus From_analysis: OMA
            Inparanoid_8
            WormBase-Compara
      WBGene00185064 Caenorhabditis brenneri From_analysis: OMA
            TreeFam
            Inparanoid_8
            WormBase-Compara
      WBGene00194510 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00193811 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00194202 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00192144 Caenorhabditis brenneri From_analysis: TreeFam
            WormBase-Compara
      WBGene00217232 Caenorhabditis japonica From_analysis: TreeFam
            WormBase-Compara
      WBGene00129190 Caenorhabditis japonica From_analysis: Inparanoid_8
            WormBase-Compara
      WBGene00161077 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00191544 Caenorhabditis brenneri From_analysis: WormBase-Compara
      WBGene00223585 Brugia malayi From_analysis: WormBase-Compara
      CBOVI.g8138 Caenorhabditis bovis From_analysis: WormBase-Compara
      CSP21.g3962 Caenorhabditis parvicauda From_analysis: WormBase-Compara
      CSP26.g13155 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP26.g8816 Caenorhabditis zanzibari From_analysis: WormBase-Compara
      CSP28.g21125 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP28.g554 Caenorhabditis panamensis From_analysis: WormBase-Compara
      CSP29.g608 Caenorhabditis becei From_analysis: WormBase-Compara
      CSP31.g2169 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP31.g7784 Caenorhabditis uteleia From_analysis: WormBase-Compara
      CSP32.g9887 Caenorhabditis sulstoni From_analysis: WormBase-Compara
      CSP38.g15180 Caenorhabditis quiockensis From_analysis: WormBase-Compara
      CSP39.g10279 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP39.g9418 Caenorhabditis waitukubuli From_analysis: WormBase-Compara
      CSP40.g10645 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      CSP40.g741 Caenorhabditis tribulationis From_analysis: WormBase-Compara
      Cang_2012_03_13_00070.g3353 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_00070.g3362 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cang_2012_03_13_01497.g16476 Caenorhabditis angaria From_analysis: WormBase-Compara
      Cni-sec-24.1 Caenorhabditis nigoni From_analysis: WormBase-Compara
      Csp11.Scaffold507.g2471 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold507.g2472 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold630.g17349 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp11.Scaffold630.g17350 Caenorhabditis tropicalis From_analysis: WormBase-Compara
      Csp5_scaffold_00164.g6048 Caenorhabditis sinica From_analysis: WormBase-Compara
      FL83_23226 Caenorhabditis latens From_analysis: WormBase-Compara
      GCK72_014152 Caenorhabditis remanei From_analysis: WormBase-Compara
      OTIPU.nOt.2.0.1.g09045 Oscheius tipulae From_analysis: WormBase-Compara
      Pan_g5613 Panagrellus redivivus From_analysis: WormBase-Compara
      Sp34_40326300 Caenorhabditis inopinata From_analysis: WormBase-Compara
      chrIV_pilon.g11878 Caenorhabditis elegans From_analysis: WormBase-Compara
      WBGene00207737 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00209975 Caenorhabditis japonica From_analysis: WormBase-Compara
      WBGene00194782 Caenorhabditis remanei From_analysis: WormBase-Compara
      WBGene00241863 Onchocerca volvulus From_analysis: WormBase-Compara
      WBGene00258515 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00265607 Strongyloides ratti From_analysis: WormBase-Compara
      WBGene00287576 Trichuris muris From_analysis: WormBase-Compara
      SGD:S000001140 Saccharomyces cerevisiae From_analysis: EnsEMBL-Compara
            Hieranoid
            OMA
            OrthoFinder
            Panther
            PhylomeDB
      FB:FBgn0262126 Drosophila melanogaster From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-070117-2501 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      ZFIN:ZDB-GENE-030131-4487 Danio rerio From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10705 Homo sapiens From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      HGNC:10706 Homo sapiens From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1916858 Mus musculus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      MGI:1919746 Mus musculus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1311720 Rattus norvegicus From_analysis: EnsEMBL-Compara
            Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
      RGD:1597739 Rattus norvegicus From_analysis: Hieranoid
            Inparanoid
            OMA
            OrthoFinder
            OrthoInspector
            Panther
            PhylomeDB
            SonicParanoid
    Paralog: WBGene00004756 Caenorhabditis elegans From_analysis: Panther
            WormBase-Compara
    Structured_description: Concise_description: sec-24.1 encodes one of two C. elegans Sec24 homologs; in Saccharomyces cerevisiae, Sec24 is a member of the Sec24-Sec23 subunit of the COPII coat complex, assembly of which is essential for the first step of secretory protein transport from the endoplasmic reticulum (ER) to the Golgi; by homology with Sec24, SEC-24.1 is predicted to facilitate vesicle cargo selection, and likely contains multiple, independent sites for binding to secreted proteins; loss of sec-24.1 activity via RNAi indicates that SEC-24.1 is required for cuticle secretion and oogenesis. Paper_evidence: WBPaper00011684
            WBPaper00013299
          Curator_confirmed: WBPerson1843
          Date_last_updated: 17 Jun 2004 00:00:00
      Automated_description: Predicted to enable SNARE binding activity and zinc ion binding activity. Predicted to be involved in COPII-coated vesicle cargo loading. Predicted to be located in endoplasmic reticulum exit site. Predicted to be part of COPII vesicle coat. Expressed widely. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Is an ortholog of human SEC24D (SEC24 homolog D, COPII coat complex component). Paper_evidence: WBPaper00065943
          Curator_confirmed: WBPerson324
            WBPerson37462
          Inferred_automatically: This description was generated automatically by a script based on data from the WS291 version of WormBase
          Date_last_updated: 29 Nov 2023 00:00:00
  Disease_info: Potential_model: DOID:0060438 Homo sapiens Inferred_automatically: Inferred by orthology to human genes with DO annotation (HGNC:10706)
  Molecular_info: Corresponding_CDS: F12F6.6
    Corresponding_transcript: F12F6.6.1
    Other_sequence (65)
    Associated_feature: WBsf668347
      WBsf981824
      WBsf997872
      WBsf997873
      WBsf997874
      WBsf1018224
      WBsf230894
      WBsf230895
  Experimental_info: RNAi_result (12)
    Expr_pattern: Expr5746
      Expr13312
      Expr1017366
      Expr1032352
      Expr1148399
      Expr2015714
      Expr2033946
    Drives_construct: WBCnstr00002791
      WBCnstr00035408
    Construct_product: WBCnstr00018415
      WBCnstr00018416
      WBCnstr00035408
    Microarray_results (23)
    Expression_cluster (136)
    Interaction (52)
  Map_info: Map: IV Position: 5.00291 Error: 0.000895
    Positive: Positive_clone: F12F6 Inferred_automatically: From CDS info
            From sequence, transcript, pseudogene data
    Pseudo_map_position
  Reference: WBPaper00028945
    WBPaper00038491
    WBPaper00049330
    WBPaper00050029
    WBPaper00055090
    WBPaper00058870
    WBPaper00060970
    WBPaper00062332
    WBPaper00064057
  Remark: Sequence connection from [Johnstone IL], [020809 krb]
    Map position created from combination of previous interpolated map position (based on known location of sequence) and allele information. Therefore this is not a genetic map position based on recombination frequencies or genetic experiments. This was done on advice of the CGC. CGC_data_submission
  Method: Gene